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Voltaren Tablets instructions for use

ATX M01AB05 Code

Pharmacotherapeutic group : NSAIDs.

Dosage form : tablets for internal use.

Form release : round biconvex tablets of yellow color with a facet, on one side a CG print, on the other - BZ. Covered with enteric coating. Contour cellular packing, cardboard pack.

Pharmacological properties

Anti-inflammatory, analgesic, antipyretic.

Composition:

Active substances :

  • sodium diclofenac.

Auxiliary components :

  • microcrystalline cellulose;
  • magnesium stearate;
  • hydroxypropylmethylcellulose;
  • hydroxystearate;
  • colloidal silicon dioxide;
  • polyvinylpyrrolidone K30;
  • titanium dioxide;
  • iron oxide yellow;
  • iron oxide red;
  • corn starch;
  • talc;
  • silicone emulsion;
  • macrogol 8000;
  • copolymer of esters and acids (methacrylic, polyacrylic);
  • sodium carboxymethyl starch;
  • glyceryl polyethylene glycol.

Pharmacodynamics

The active component of the drug is a substance of non-steroid nature, which has a pronounced antipyretic, anti-inflammatory and analgesic effect. The main mechanism is the inhibition of the biological synthesis of prostaglandins, which play a leading role in the genesis of pain, inflammation and fever. This drug has no overwhelming effect on the biosynthesis of cartilage proteoglycans.

In the treatment of pathologies of rheumatic nature, the severity of pain, morning stiffness and swelling of the articular joints are significantly reduced, improvement of their functioning is noted.

In case of inflammation of postoperative or post-traumatic origin, the drug also has an analgesic effect. However, it is able to eliminate pain and reduce the severity of blood loss in primary dysmenorrhea. Suppresses migraine attacks.

Pharmacokinetics

Tablets, enteric-coated, after oral administration are completely absorbed in the intestine. In the event that the drug is taken during or immediately after a meal, its slow passage through the stomach is noted, but the amount of the active component that is absorbed does not change.

After a single dose of 50 mg of Voltaren, the maximum plasma concentration of diclofenac (1.5 μg / ml) is observed after 2 hours. The degree of absorption of the drug depends on the dose. With strict adherence to the intervals between tablets pills cumulation is not observed.

Communication with plasma proteins is 99.7% (99.4% with albumin). In synovial fluid, diclofenac reaches its maximum concentration 2-4 hours later than in plasma. The half-life of the drug in synovia is 3-6 hours.

Diclofenac is metabolized in the liver, with the formation of phenolic metabolites, which turn into glucuronide conjugates.

The total plasma clearance of the active component is 263 plus or minus 56 ml / min. The final half-life is 1-2 hours. T 1/2 metabolites - 1-3 hours. About 60% of the drug is excreted by the kidneys with urine, the rest - with feces.


Indications for use

  • Inflammatory and degenerative-dystrophic pathologies of the musculoskeletal system (osteoarthritis, rheumatoid and juvenile arthritis, spondyloarthropathy, gouty arthritis, tendovaginitis, chronic arthritis, bursitis, etc.);
  • Post-traumatic or postoperative pain syndrome (in orthopedics, dentistry);
  • Pain in the spine (radiculitis, ossalgia, sciatica, etc.);
  • Algomenorrhea;
  • Infectious and inflammatory pathologies of upper respiratory tract, accompanied by severe pain syndrome (otitis, tonsillitis , pharyngitis );
  • Adnexitis and other pelvic inflammatory diseases

Voltaren tablets are a drug of symptomatic action, eliminating the clinical manifestations of the disease, but not affecting its progression.

Contraindications

  • Peptic ulcer and 12-p intestine (aggravation, perforation phase, ulcer bleeding);
  • Ulcerative colitis, Crohn's disease (acute phase);
  • Severe renal failure;
  • Heart failure (decompensation stage);
  • Severe liver failure;
  • The attacks of asthma, rhinitis, urticaria , triggered by the intake of acetylsalicylic acid;
  • Conditions involving the risk of bleeding;
  • Hyperkalemia;
  • Coronary artery bypass surgery (pre- and postoperative period);
  • Individual intolerance to the components of the drug;
  • III trimester of pregnancy and lactation;
  • Children's age up to 14 years.

Dosage and administration

The dosage of the drug is determined individually. If possible, the drug is prescribed in the minimum effective dose, with the shortest possible course of treatment.

Tablets are recommended to be taken after food, swallowing whole and drinking water.

The initial recommended dose for adults is 100-150 mg per day. In milder forms of pathology, 75-100 mg per day is sufficient.

In primary dysmenorrhea, the daily dose is 50-150 mg. Initial - 50-100 mg / day, if necessary, increases to 150 mg. The drug is recommended to begin to use when the first symptoms occur. Depending on the condition of the patient, treatment is allowed for several days.


Side effect

On the part of the digestive system : nausea, vomiting, diarrhea, abdominal pain, loss of appetite, anorexia, dyspepsia.

From the senses : visual impairment (rarely), hearing impairment, vertigo.

On the part of the nervous system : dizziness, headaches, taste disturbances. Rarely tremor of extremities, memory disorders, convulsions , acute cerebrovascular accident.

On the part of the respiratory system : pneumonitis, asthma.

Since the cardiovascular system : hypertension, hot flashes, vasculitis, heart failure, myocardial infarction.

On the part of the urinary system : proteinuria, hematuria, acute renal failure, papillary necrosis, nephrotic syndrome.

On the part of the skin: hyperemia, generalized rash, itching, dermatosis, alopecia.

Other disorders : peripheral and generalized edema, swelling of the face.

Drug interactions

Diclofenac can increase plasma concentration of digoxin and lithium.

When used simultaneously with potent inhibitors of CYP2C9 in the serum, the concentration of diclofenac increases, and the systemic effect of the drug increases due to inhibition of its metabolism.

NSAIDs reduce the hypotensive effect of diuretics and antihypertensive drugs.

With simultaneous use with other NSAIDs systemic action increases the frequency of adverse reactions from the digestive tract.

When interacting with selective serotonin reuptake inhibitors, the risk of gastric bleeding increases significantly.

Simultaneous use with methotrexate increases the concentration and toxic effect of the latter.

Enhances the nephrotoxicity of cyclosporins.

Enhances the systemic effect of phenitonin.

Overdose

  • Hypotension;
  • Digestive disorders;
  • Renal failure;
  • Cramps.

Vacation conditions

Refers to prescription drugs.

Storage conditions

Store in a dry, protected from light, out of reach of children at a temperature not exceeding 30 ° C.

Shelf life

The shelf life of the drug is 5 years from the date of issue. After the expiration date indicated on the package, the drug is not allowed to use.

Voltaren tablets Price

Voltaren tablets 50 mg, 20 pieces - 260 - 300 rubles.

Voltaren tablets tablets

  • Diclofenac Sandoz;
  • Diclonat P;
  • Naklofen;
  • Dicloran.
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Reviews of the drug Voltaren tablets:

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Michele Buring: It is just another toxic garbage drug causing massive negative environmental devastation as well as being just plain bad for everybody. There are a multitude of safe natural alternatives which need to be used instead of this stupid drug. This drug is famous for having caused the death of multiple millions of birds - via the domino affect of its use in the environment. Look after your health intelligently. It’s always easy to find safe holistic remedies then go and get more of the drug industry garbage that’s causing iatrogenic premature death of millions. Stop enabling one of the most disgustingly corrupt industries on the face of this planet to continue it’s profiteering - and exploitation of everything and everybody.

Dustin Yambrisak: My pain management Dr prescribed me this for my back pain and it seems to work so far.. (Keeping my fingers crossed) Does upset my stomach a bit I must say

nmorin83: This medicine makes me extremely sleepy when I take it and the next day I'm exhausted. Like I just want to sleep all day. I tried just taking as needed (as prescribed) but it's for my foot and since I'm on my feet a lot I need it more frequently. Thankful I won't need this for long (having surgery to fix the problem), because I am so so sleepy.

Rosza Thorns: It makes me extremely drowsy all day and my stomach has been upset since the start of this medication. I also experienced extreme nausea... This I an addictive med!

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