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Vesicare Instructions for Use

Vesicare - a drug that helps reduce the tone of smooth muscles of the urinary tract. Belongs to a group of antispasmodics. It is used to treat urological diseases.

Release form and composition

Vesicare is produced in the form of film-coated tablets in dosages of 5 mg and 10 mg. The tablets in blisters with the instruction are placed in a carton (10 and 30 tablets per pack).

The main active ingredient is solifenacin succinate.

Auxiliary components: lactose monohydrate, corn starch, hypromellose, magnesium stearate.

The components that make up the shell are: macrogol, hypromellose, talc, titanium dioxide, dyes - iron oxide red (10 mg tablets) or yellow (5 mg tablets).

pharmachologic effect

Pharmacodynamics. Solifenacin has a pronounced antispasmodic effect. It is a specific competitive inhibitor of muscarinic cholinergic receptors (mainly M 3 -subtype). In this case, the active substance does not show or has a low degree of affinity for other receptors and ion channels.

The therapeutic effect of the drug is noted already in the first week of treatment, it stabilizes in the next 12 weeks of Vesicare application. The maximum therapeutic effect is achieved on average after 4 weeks of treatment. The effectiveness of therapy lasts up to a year.

Pharmacokinetics. The maximum concentration of solifenacin in the blood plasma is reached 3–8 hours after taking the pills. At the same time, the maximum concentration indicator increases in proportion to the dose increase from 5 mg to 40 mg. The absolute bioavailability of solifenacin is 90%. About 98% of the active substance is bound to blood proteins. The speed and extent of absorption is not affected by meal times.

Solifenacin is cleaved in the liver to the active and three inactive metabolites. The half-life of the active substance ranges from 45 to 68 hours. Excreted by the kidneys and through the intestines.

Indications for use

Vesicare is used in the symptomatic treatment of patients with overactive bladder syndrome, accompanied by:

  • imperative urinary incontinence;
  • imperative urge to urinate;
  • frequent urination.

Contraindications

Contraindications to the use of Veszicar are:

  • urinary retention;
  • severe renal failure;
  • angle-closure glaucoma;
  • severe diseases of the digestive tract (including toxic megacolon);
  • myasthenia gravis;
  • severe hepatic impairment or moderate hepatic impairment with simultaneous treatment with ketoconazole, itraconazole;
  • hemodialysis;
  • hereditary intolerance to galactose, lactase deficiency, glucose-galactose malabsorption;
  • individual intolerance or hypersensitivity to the main or one of the auxiliary components of the drug;
  • childhood.

Dosing and Administration

The recommended dosage of the drug for adults (over 18 years) and the elderly is 5 mg per day. If necessary, the dose is increased to 10 mg per day. Tablets are taken orally, in its entirety, daily (at the same time), regardless of the time of eating food. Drink with enough liquid.

Side effects

When taking Vesicare in some cases, undesirable side effects may develop:

  • on the part of the nervous system - mild headache, mild dizziness, moderate dry mouth, drowsiness, very rarely - nonsense, confusion, hallucinations;
  • on the part of the organs of sight - disturbance of accommodation (indistinct visual perception), dryness of the mucous membrane of the eyes, glaucoma;
  • on the part of the digestive system - nausea and dyspeptic symptoms (heartburn, bloating), abdominal pain, constipation, gastroesophageal reflux disease and intestinal obstruction, coprostasis, deterioration of appetite, vomiting;
  • on the part of the liver - impaired liver function, changes in laboratory parameters of liver tests;
  • on the part of the excretory system - difficulty urinating, infectious inflammation of the urinary tract, cystitis , acute urinary retention, renal failure (very rarely);
  • on the part of the respiratory system - dry nasal mucosa;
  • from other organs and systems - edema of the lower extremities, fatigue;
  • dermatological and allergic reactions - dry skin, itching and rash, urticaria , erythema multiforme, exfoliative dermatitis.

In the event of side effects, a dose reduction or drug withdrawal is required, sorbents are taken, gastric lavage (must be performed within 1 hour after poisoning, and vomiting cannot be induced). If necessary, means of symptomatic therapy are prescribed.

In case of overdose of solifenacin, severe disorders develop, requiring immediate treatment. Can develop:

  • anticholinergic effects of central action (marked excitability, hallucinations) - carbachol, physostigmine is used;
  • convulsions and severe irritability - benzodiazepines are prescribed;
  • respiratory failure - artificial respiration is performed;
  • acute urinary retention - catheterization is performed;
  • tachycardia - β-blockers are assigned;
  • mydriasis (dilated pupil) - eyes are buried with pilocarpine, the patient moves into a dark room.

special instructions

With care, Vesicare is prescribed to patients with certain comorbidities, including:

  • bladder outlet obstruction;
  • obstructive diseases of the digestive tract (including stagnation of food in the stomach);
  • delayed motility of the digestive tract;
  • hiatal hernia;
  • gastroesophageal reflux;
  • autonomic neuropathy;
  • hypokalemia.

During treatment with Vesicare, the following points should be taken into account:

  • Before starting treatment, it is important to ensure that there are no other causes of involuntary urination (kidney disease, heart failure);
  • antibiotic therapy is required when a urinary tract infection is detected;
  • no need for dosage adjustment for elderly patients;
  • pharmacokinetics and pharmacodynamics of the active substance in children and adolescents has not been studied, so the drug is not prescribed to patients under 18 years of age;
  • After treatment with solifenacin, a week break should be taken before using the drugs of the M-holinoblokatorov group;
  • Vesicare can cause a violation of visual ability to clearly distinguish objects, drowsiness, fatigue, so care must be taken during treatment of patients whose activities require high concentration of attention and speed of reaction (including when driving vehicles and controlling other mechanisms).

Drug Interactions:

  • while taking with M-cholinomimetics, the therapeutic effect of solifenacin is reduced;
  • with the simultaneous use of Vesicare with M-anticholinergics, the therapeutic effect and side effects of solifenacin are enhanced;
  • with simultaneous use of solifenacin reduces the therapeutic effect of drugs that stimulate the motility of the digestive tract (cisapride, metoclopramide and others);
  • ketoconazole, itraconazole, ritonavir, nelfinavir increase the bioavailability of solifenacin, therefore, with the simultaneous use of these drugs with the maximum dose of Vesicare should not exceed 5 mg; and in patients with severe renal and moderate hepatic insufficiency, these drugs cannot be taken at the same time;
  • combination of solifenacin with verapamil, diltiazem, rifampicin, carbamazepine, phenytoin is not recommended.

Pregnancy and lactation

Clinical data on the safety and efficacy of Vesicare in pregnant women are not available, therefore, it is necessary to prescribe the drug with caution during pregnancy.

No data on the penetration of solifenacin into breast milk. The drug is not recommended for use during breastfeeding.


Vesicars analogs

A complete structural analogue of Vesicare, which includes solifenacin, is Zevesin.

For similar therapeutic effects, but having a different composition of drugs include: Novitropan, Driptan, Detruzitol, Drimtan-Apo, Urotol, Sibutin.

Terms and conditions of storage

The drug is stored in a place protected from moisture and sunlight, inaccessible to children, at a temperature not exceeding 25 ° C. Shelf life is 3 years. Do not take pills after the expiration date indicated on the package.

Vesicare price

Vesicare tablets 5 mg - 780-1330 rub. (depending on the number of pills)

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