Wessel Due F ampoules
Wessel Duye F solution is a biological drug, the main active ingredient of which has the ability to reduce blood clotting, so the drug belongs to the pharmacological group of anticoagulants. It is used in the treatment of diseases that are accompanied by increased blood clotting.
Release form and composition
Wessel Duye F solution is intended for parenteral administration. It has a light yellow or yellow color, transparent. The main active ingredient is sulodexide, 1 ml of solution contains 600 LU (medicinal units) of this active ingredient. Also in the composition of the drug as a solvent includes water for injection. The solution is packaged in 2 ml ampoules, which are in blisters in an amount of 10 pieces. The carton pack contains 1 blister packaging and instructions for use of the drug.
The main active ingredient of the Wessel Due F Sulodexide solution is an extract of the mucous membrane of the small intestine of the pig. It is a biologically active compound, 80% of which is heparinoid (in terms of its properties and chemical structure, it is close to heparin) and 20% of dermatan sulfate. These components provide anticoagulant (reduced blood clotting) and hypolipidemic (reduced blood lipids) action due to such effects:
- Inhibition of aggregation (gluing together) and adhesion (attachment to the walls of blood vessels) platelets.
- Reducing the level of fibrinogen in the blood, which is the main substrate of the blood clot.
- Increased tissue plasminogen is an enzyme that promotes the resorption of a blood clot.
- Inhibition of protein factor X of the blood coagulation system.
- Blocking the enzyme, an inhibitor of tissue plasminogen.
- Increased activity of the enzyme lipoprotein lipase, which breaks down atherogenic lipoproteins (leading to the deposition of cholesterol in the walls of blood vessels).
Sulodexide also reduces the activity of proliferation of smooth muscle cells, thereby reducing the activity of the process of atherosclerotic plaque formation on the artery wall.
After parenteral (intramuscular or intravenous) administration, the concentration of sulodexide increases in the blood and reaches a therapeutic dose within 15 minutes. Then, the main active ingredient accumulates in the walls of arterial vessels, where it exerts its therapeutic action, and its concentration in the arteries is several times higher than in other tissues of the body. Sulodexide is largely excreted in the urine by the kidneys, the half-life (the time during which 50% of the total dose of the drug is excreted from the body) is about 12 hours.
Indications for use
The use of the Wessel Dué F solution is indicated for pathological conditions involving a high risk of thrombus formation in vessels without disrupting the integrity of their walls and putting cholesterol in them (formation of atherosclerotic plaques):
- Angiopathy is a disease of the vascular wall with a high risk of thrombus formation, including after myocardial infarction.
- Severe circulatory disorders in the brain, including ischemic stroke.
- Dyscirculatory encephalopathy (functional and organic disorders of cerebral circulation) on the background of diabetes mellitus, hypertension or atherosclerosis of blood vessels.
- Vascular dementia is a decrease in intelligence and mental capacity due to prolonged insufficiency of blood supply to the cerebral cortex.
- Phlebopathy is a pathology of the venous vessels, accompanied by thrombosis in them (including thrombosis of the deep veins of the extremities).
- Microangiopathy - somatic changes in the vessels of the microvasculature (capillaries), leading to a decrease in the volume of blood flow in them (angiopathy of the retina of the eye, kidney, peripheral nerves).
- Macroangiopathy is a pathological process in the large vessels of the feet, kidneys, heart, and brain with a corresponding deterioration in blood circulation.
- Blood diseases accompanied by increased clotting - thrombophilic conditions, antiphospholipid syndrome.
Also, the drug is used in the complex treatment of heparin-induced thrombocytopenia (decrease in the number of platelets in the blood).
There are several pathological and physiological states of the body in which the use of the drug is contraindicated:
- Individual intolerance or hypersensitivity to sulodexid or auxiliary components of the solution Wessel Due.
- Hemorrhagic diathesis - blood pathology, accompanied by a decrease in its clotting.
- Any pathological conditions in which blood clotting is reduced, including certain phases of DIC (disseminated intravascular coagulation syndrome).
- Pregnancy in the first trimester.
Before you start using the drug, you must make sure that there are no contraindications.
Dosage and administration
Solution Vessel Due f is injected parenterally - intramuscularly or intravenously. Depending on the severity of the underlying pathology, the drug can be administered intravenously (ischemic cerebral stroke, acute circulatory disorders in various organs) in an amount of 2 ml. With moderate course of the pathological process, the solution is injected intramuscularly in the amount of 2 or 4 ml (depending on the severity of coagulation). Usually, the drug is administered 1 time per day, the duration of therapy is determined by the attending physician, based on the clinical course of the pathology and laboratory parameters of blood clotting (the duration of the course varies from 5 to 20 days). Also, after the main course of treatment, they switch to oral administration of the Wessel Due F drug in the form of capsules.
The use of Wessel Due F solution can lead to the development of side effects and negative reactions from various organs and systems:
- The digestive system - nausea, vomiting, pain and discomfort in the abdomen (more pronounced after using the oral form of the drug). In rare cases, gastrointestinal bleeding may develop.
- Central nervous system - headache, dizziness, rarely can be loss of consciousness.
- Red bone marrow and blood system - anemia (decrease in hemoglobin level and red blood cell count).
- The urinary and reproductive system - swelling of the genitals, in women polymenorrhea (heavy menstruation).
- Allergic reactions - a rash on the skin often develops, itching, urticaria (elements of the rash on the background of swelling resemble a nettle burn). Less commonly, angioedema, angioedema of the angioedema (pronounced swelling of the skin and subcutaneous tissue in the face and external genitalia) or anaphylactic shock (development of multiple organ failure).
In case of symptoms of side effects, the use of the drug is stopped.
Wessel Doue F solution is used only in a medical hospital under constant laboratory control of the functional activity of the blood coagulation system, liver and kidneys. The introduction of the drug to pregnant women in late periods and breastfeeding women is possible only after a doctor's prescription, when the expected effect on the mother outweighs the potential risk to the fetus or infant. During treatment, it is not recommended to perform work that requires an increased concentration of attention and speed of psychomotor reactions, since the development of side effects from the central nervous system is possible. The drug in pharmacies is available only on prescription.
A significant excess of the recommended therapeutic dose of the Wessel Due F solution develops bleeding of different localization (in the joints, gastrointestinal bleeding). In such cases, the drug must be canceled, the introduction of a 1% solution of protamine sulfate, observation and control of laboratory parameters of the blood coagulation system.
Wessel Due F analogues
Analogues of the drug on the pharmacological and therapeutic effect are Axparin, Atenativ, Clexane.
Terms and conditions of storage
The shelf life of the Wessel Due F solution is 5 years from the date of manufacture. It must be stored in a dark place inaccessible to children at an air temperature not higher than + 25 ° C.
Wessel Due F Price
The average cost of the Wessel Due F solution in pharmacies in Moscow varies between 1715-1892 rubles.