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Wessel Due F instructions for use

ATX code B01AV11

Pharmacotherapeutic group : anticoagulants.

Dosage form : capsules, solution for intravenous and intramuscular injections.

Product form : soft oval gelatin capsules of brick-red color, containing a suspension of white-gray, pinkish or pinkish-cream color, blister, cardboard pack;

Transparent yellow or light yellow solution, ampoules, blister packaging, cardboard box.

Pharmacological properties

Anticoagulant drug of direct action. This preparation is a natural product, extracted from the small intestine of a domestic pig. Presented as a mixture of dermatan sulfate, heparin-like fraction and glycosaminoglycans. The mechanism of action of the anticoagulant is due to the affinity of the fast-acting heparin fraction to antithrombin III, and the dermatan fraction to the heparin cofactor II.

Composition:

Active ingredient :

  • Sulodexide (250 LE (capsules) 600 LE (injection)).

Auxiliary components :

Capsules: colloidal silicon dioxide, triglycerides, sodium lauryl sarcosinate. Gelatin shell: glycerol, gelatin, titanium dioxide, sodium ethylparaoxybenzoate, sodium propyl paraoxybenzoate, iron oxide red.

Injection solution : sodium chloride, water for injection.

Pharmacodynamics

Anti-coagulation properties of the drug are manifested due to its affinity for heparin cofactor II, which inactivates thrombin. The mechanism of antithrombotic action is due to the suppression of activated X factor, increased synthesis and secretion of PGI 2 and a decrease in plasma level of fibrinogen.

The pro-fibrinolytic effect of the anticoagulant is caused by an increase in the level of plasminogen activator and a decrease in the amount of its inhibitor in the blood.

With the restoration of the functional and structural integrity of the vascular endothelium and the restoration of the density of the negative electric charge of the porbasal membrane, the angioprotective effect of the drug is associated. At the same time, Vesel Due F, due to stimulation of lipoprotein lipase, which hydrolyzes triglycerides that make up LDL, normalizes the rheological properties of blood.

The effectiveness of the anticoagulant in diabetic nephropathy is determined by the ability of the active component, due to the proliferation of mesangium cells, to reduce the production of extracillary matrix and the thickness of the basement membrane.

Pharmacokinetics

About 90% of sulodexide is adsorbed in vascular endothelium cells. Here, its concentration is 20-30 times higher than the concentration in other tissues. Absorption occurs in the small intestine.

Meselized Vesel Due f in the kidneys and liver and excreted 4 hours after application. Active component is not subjected to desulfation. As a result, no decrease in its antithrombotic activity is observed and elimination from the body is not accelerated.

After 24 hours after intravenous administration of the drug, its secretion with urine is 50%, and after 2 days - 67%.


Indications for use

  • Angiopathies characterized by a high risk of thrombosis (including after myocardial infarction);
  • Deep vein thrombosis;
  • Violation of cerebral circulation;
  • Encephalopathy;
  • Phlebopathy;
  • Thrombophilic conditions;
  • Microangiopathies of various genesis;
  • Antiphospholipid syndrome;
  • Heparin-induced thrombotic thrombocytopenia.

Contraindications

  • Individual intolerance to the components of the drug;
  • Pathological conditions accompanied by low blood clotting;
  • Hemorrhagic diathesis;
  • I trimester of pregnancy.

Dosage and administration

Injection solution for intramuscular or intravenous administration.

1 ampoule of the drug is administered daily, intravenously or intramuscularly, for 15-20 days. When administered bolus or drip, the anticoagulant is pre-dissolved in 150-200 ml of saline.

Capsules

Reception of capsules Vesel Doue F is recommended for the next 30-40 days (1 capsule twice a day, between meals). The course of treatment is prescribed twice a year. The dosage regimen of the drug can be changed by the attending physician. Of course, the results of the clinical diagnostic examination should be taken into account.


Side effect

On the part of the digestive tract : pain in the epigastric region, nausea, vomiting.

On the part of the skin : itching, urticaria , skin rashes of different localization.

Other disorders : burning, soreness and hematoma formation at the injection site.

Drug interactions

With the simultaneous use of anticoagulant with other drugs significant interaction of the components is not installed. It is not recommended to use together with Vesel Doue F as direct and indirect anticoagulants and antiplatelet agents that affect the hemostatic system.

special instructions

The use of the drug should be under the control of a coagulogram. Before and at the end of treatment, it is necessary to determine the clotting time and bleeding, antithrombin II and activated partial thromboplatin time (when using the drug, the last indicator increases 1.5 times). The fun of Douai F does not affect the ability to drive a car and control mechanized equipment.

If necessary, use during pregnancy treatment should be under the strict supervision of a physician.

Overdose

With an overdose of the drug may be bleeding and bleeding. In this situation, it is necessary to cancel the anticoagulant and conduct symptomatic therapy.

Vacation conditions

Refers to prescription drugs.

Storage conditions

Store in a dry, protected from light, out of reach of children at a temperature not exceeding 30 C.

Shelf life

The shelf life of the drug is 5 years from the date of issue. After the expiration date indicated on the package, the drug is not allowed to use.

Average price in Moscow pharmacies

2855.00 rubles.

Vessel Due F Analogs

  • Angioflux;
  • Sulodexide.
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