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Vepr Spray: instructions for use

ATX H05BA01 Code

Pharmacotherapeutic group : correctors of bone and cartilage tissue metabolism

Dosage form : spray for nasal use.

Release form : transparent colorless liquid, without foreign inclusions, a bottle with a spraying dosing device, a cardboard box.

Pharmacological properties

Drug that regulates calcium-phosphorus metabolism and has anti-osteoporotic and calcitonin action.

Composition:

Active ingredient :

  • Calcitonin salmon synthetic.

Auxiliary components :

  • sodium chloride;
  • benzalkonium chloride;
  • concentrated hydrochloric acid;
  • purified water for injection.

Pharmacodynamics

The hormone calcitonin, synthesized by C-cells of the thyroid gland, acts as an antagonist of parathyroid hormone (PGT), with which it participates in the regulation of calcium metabolism. Salmon synthetic calcitonin, in comparison with mammalian calcitonin, has a higher affinity for receptors. As a result, its action is more pronounced both in strength and in duration. Due to the impact on specific receptors, it inhibits the activity of osteoclasts, as well as, with osteoporosis (in a state with an increased rate of resorption), it normalizes the rate of bone tissue metabolism.

When pain of bone origin, due to the direct impact on the central nervous system, has an analgesic effect. Already after a single use, a clinically significant response develops, manifested by an increase in urinary excretion of calcium, sodium, phosphorus and hydroxyproline.

With prolonged use of the drug there is a persistent and significant decrease in the level of bone isoenzymes and serum C-telopeptides. The use of Veprén's spray contributes to an increase in bone mineral density of the lumbar vertebrae and femur. Its increase is noted already in the first year of use of the drug and lasts for 5 years.

In the case of using the drug (200 IU / day) in combination with calcium supplements and vitamin D, there is a clinically and statically significant reduction in the risk of multiple vertebral fractures.

When using the drug decreases secretion and exocrine function of the pancreas.

Pharmacokinetics

Veprine nasal spray is almost instantly absorbed through the nasal mucosa, reaching maximum plasma concentration within 10 minutes. Absolute bioavailability of the drug is 3-5%. At use of the doses exceeding recommended, this indicator does not increase. Determining the concentration of polypeptide hormones in plasma is not of significant value, since the therapeutic effect of the drug does not depend on these values. Therefore, the activity of the nasal spray is evaluated by clinical efficacy indicators. Synthetic salmon calcitonin is not able to penetrate the placental barrier. Its half-life is 20 minutes. With repeated use, accumulation (cumulation) in tissues is not observed.


Indications for use

  • Osteochondrosis of unspecified etiology;
  • Neck and shoulder syndrome and other dorsopathies;
  • Osteitis deformans (Paget's disease);
  • Shoulder adhesive capsulitis;
  • Osteolysis;
  • Postmenopausal osteoporosis;
  • Algoneurodystrophy;
  • Sudek's atrophy;
  • Unspecified bone diseases;
  • Osteopathy, which is a consequence of diseases classified in other headings.

Contraindications

  • Individual intolerance or hypersensitivity to the drug;
  • Children and adolescents (up to 18 years);
  • Pregnancy and lactation (in the absence of clinical safety data);

Dosage and administration

Veprina (spray) is a means for intranasal use. The drug is recommended to be administered alternately at first into one, then into the other nasal passage. The daily dose in the treatment of osteoporosis is 200 IU / day. For prophylactic purposes, the drug is recommended for a long time to use simultaneously with vitamin D and adequate doses of calcium.

In the treatment of osteopenia or osteolysis, the daily dose is 200-400 IU / day. 200 IU / day is allowed to enter a one-time, and a higher dose should be divided into several injections. For maximum analgesic effect, it usually takes several days. If you need long-term therapy, the initial daily dose should be reduced, or the interval between injections should be increased.

On average, the treatment course is 3 months. According to medical indications, it can be increased. In this situation, the daily dose of the drug is adjusted according to the individual needs of the patient.

In case of Paget's disease, the daily dose of the drug should be 200 IU / day. If necessary, increase it to 400 IU / day, the drug must be administered several times a day.

In the treatment of neurodystrophic pathologies, the drug is used daily for 2-4 weeks (200 IU / day). According to medical indications, additional treatment may be prescribed (for 6 weeks every other day).

Older people and patients suffering from renal or hepatic pathologies do not need to change the dosage regimen of the drug.


Side effect

On the part of the digestive system : nausea, vomiting, diarrhea, abdominal pain.

From the senses : visual disturbances (rarely).

On the part of the nervous system : dizziness, headaches, taste disturbances.

On the part of the respiratory system : dryness, congestion, pain in the nasal cavity, erythema, swelling of the nasal mucosa, sneezing, runny nose of allergic origin, irritation, formation of excoriations, unpleasant smell, nasal bleeding, sinusitis, pharyngitis , cough, ulcer rhinitis.

Since the cardiovascular system : hypertension, hot flashes.

On the part of the immune system : the development of hypersensitivity, very rarely - anaphylactic reactions, anaphylactic shock.

From the urinary system : polyuria.

On the part of the skin: hyperemia, generalized rash.

On the part of the musculoskeletal system : arthralgia, muscle and bone pain.

Other disorders : flu-like syndrome, fatigue, itching at the injection site, peripheral and generalized edema, swelling of the face.

Drug interactions

With the simultaneous use of nasal spray with Vepren lithium preparations, a decrease in plasma concentration of the latter is possible. In this regard, it may be necessary to adjust its dose.

Overdose

In rare cases, there is dizziness, flushing, nausea and vomiting. Very rarely, the patient develops hypercalcemia, accompanied by muscle twitching (paresthesia).

Vacation conditions

Refers to prescription drugs.

Storage conditions

Store in a dry, protected from light, out of reach of children at a temperature not exceeding 2-8 C.

Shelf life

The shelf life of the drug is 2 years from the date of issue. After the expiration date indicated on the package, the drug is not allowed to use.

Average price in Moscow pharmacies

From 1290. 00 rubles.

Veprina spray analogues

  • Alostin (spray);
  • Miakaltsik (spray).
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