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Ventolin aerosol instructions for use

Ventolin is a bronchodilator drug of the β-2 group of adrenomimetics.

Release form and composition

Ventolin is available in the form of a metered-dose inhalation solution. The solution is a suspension of white or almost white color. 1 bottle of aerosol is designed for 200 doses of the drug. Aluminum inhalers are equipped with a plastic metering device and a protective cap, with the instruction placed in cardboard packaging.

The main active ingredient is micronized salbutamol sulfate. 1 dose contains 120.5 μg of salbutamol sulfate, which corresponds to 100 μg of salbutamol.

Auxiliary components: propellant.

pharmachologic effect

Pharmacodynamics. The drug belongs to the selective β-2 adrenoreceptor agonists. When used in therapeutic doses affects the receptors of the bronchi. At the same time, it slightly affects or does not affect the β-1 adrenoreceptors of the heart muscle at all. It has a bronchodilating effect, suppresses or prevents a spasm of smooth muscles of the bronchi. Reduces resistance in the respiratory tract, increases lung capacity. Increases mucociliary clearance (up to 36% in chronic bronchitis), activates the production of bronchial mucus, stimulates the function of the bronchial epithelium of the bronchi.

When used in the recommended dosage does not affect the cardiovascular system, does not cause hypertension. It causes the expansion of the coronary arteries.

Salbutamol affects some metabolic processes. Namely:

  • affects glycogenesis and insulin secretion;
  • lowers the level of potassium in the blood plasma;
  • It has a lipolytic and hyperglycemic (especially in asthmatics) effects;
  • increases the likelihood of acidosis.

Pharmacokinetics. The drug begins to act after 5 minutes after inhalation, the maximum therapeutic effect is observed after 30–90 minutes (at the same time 75% of the therapeutic effect is reached within 5 minutes). The average duration of therapeutic effect is from 4 to 6 hours.

The lower parts of the respiratory tract reaches 10–20% of the active substance from the entire dose administered. The remainder enters the oropharynx, is swallowed, settles on the inhaler. Salbutamol from the lower parts of the respiratory system is absorbed into the blood and lung tissues (but is not metabolized in the lungs).

Salbutamol, trapped in the digestive tract, is broken down in the liver to form inactive metabolites. About 10% of the active substance is bound to plasma proteins. The drug is excreted unchanged and in the form of metabolites for the most part by the kidneys, a small amount through the intestines. Most of the salbutamol dose is excreted for 72 hours.

Indications for use

Ventolin is recommended for the treatment of:

  • bronchial asthma;
  • chronic obstructive pulmonary disease with reversible airway obstruction;
  • chronic bronchitis.

In case of bronchial asthma, Ventolin is prescribed for:

  • relief of asthma attacks, including acute exacerbations of the disease, proceeding in a severe form;
  • prevention of attacks of bronchial asthma, due to physical exertion or exposure to an allergen;
  • long-term maintenance treatment as part of complex therapy.


Contraindications to the use of Ventolin are:

  • management of preterm labor;
  • threatened abortion;
  • hypersensitivity to the components of the drug;
  • children's age up to 2 years.

Dosing and Administration

Ventolin is used for inhalation.

The ineffectiveness of therapy and the increasing need for salbutamol may indicate a worsening of bronchial asthma. In this case, it is recommended to review the treatment regimen and consider the expediency of simultaneous use of glucocorticosteroids.

Exceeding the recommended doses can lead to the development of serious side effects, therefore, the decision to increase therapeutic dosages or frequency of use of Ventolin should be made by a doctor.

Relief of bronchial asthma

For adults, the recommended dose is 100 or 200 micrograms.

Children are given 100 mcg (in severe cases, 200 mcg) of salbutamol.

Frequency of use - no more than 4 times a day.

The need for frequent administration of maximum single doses of the drug or an increase in the frequency of administration indicates a worsening of the disease.

Prevention of bronchospasm due to exercise or allergen exposure

Adults are recommended inhalation administration of 200 μg of salbutamol 15 minutes before the expected load or contact with the allergen. The dosage for children is 100 mcg, but if necessary it can be increased to 200 mcg.

Long-term maintenance therapy

Adults and children are prescribed up to 200 mcg of salbutamol 4 times a day.

Before the first use of the aerosol or after a long break in treatment (a week or more), it is recommended to remove the cap from the mouthpiece, squeezing it from both sides to shake the inhaler well. Make 2 sprays into the air to assess the health of the device.

Side effects

The use of Ventolin can cause a number of undesirable side effects from various body systems. Namely:

  • on the part of the respiratory system - paradoxical bronchospasm (the drug is canceled, immediate treatment is carried out);
  • on the part of the cardiovascular system - tachycardia , arrhythmias, peripheral vasodilation, hypotension, collapse;
  • on the part of the nervous system - headache, tremor, hyperactivity;
  • on the part of the digestive system - irritation of the mucous membranes of the mouth and nose;
  • on the part of the musculoskeletal system - muscle cramps .
  • on the part of the metabolism - hypokalemia;
  • hypersensitivity reactions - urticaria , angioedema , bronchospasm.

In case of an overdose of salbutamol, β-adrenergic receptors are affected not only in the bronchi, but also in other organs. As a result, transient side effects occur - tachycardia, muscle tremor, lowering blood pressure, nausea and vomiting. With the introduction of large doses of salbutamol may develop hypokalemia, therefore during treatment it is recommended to monitor the level of potassium in the blood plasma.

Treatment of symptomatic salbutamol poisoning. The drug is canceled, cardio-selective β-adrenoreceptor blockers are prescribed (for tachycardia, palpitations).

special instructions

When prescribing and using Ventolin, it is important to take into account the following points:

  • therapy of asthma should be carried out in stages, under the constant control of the effectiveness of the prescribed therapy;
  • the increased need for inhalation or the use of higher doses indicates a worsening of the disease (co-administration of glucocorticosteroids may be appropriate);
  • Ventolin should not be the only / main drug in the treatment of unstable or severe asthma;
  • During treatment, it is necessary to control the content of potassium in the blood, since the use of salbutamol may cause the development of hypokalemia (especially in patients with severe asthma attacks who are simultaneously taking xanthine derivatives, diuretics, corticosteroids);
  • if the therapeutic effect has not occurred within 3 hours after inhalation, it is required to consult a doctor;
  • There is no data on the effect of Ventolin on the speed of psychomotor reactions, the ability to drive a vehicle and other mechanisms;
  • According to the testimony Ventolin can be used in children older than 2 years.

Ventolin is used with caution in patients with certain comorbidities. It:

  • tachyarrhythmia;
  • thyrotoxicosis;
  • chronic heart failure in severe form;
  • arterial hypertension;
  • decompensated diabetes;
  • pheochromocytoma;
  • glaucoma;
  • history of renal failure.

Drug Interactions:

  • simultaneous use of Ventolin with non-selective β-adrenoreceptor blockers (propranolol and others) is not recommended;
  • Ventolin can be administered simultaneously with MAO inhibitors;
  • Ventolin enhances the action of CNS stimulants in patients with thyrotoxicosis;
  • the combination of Ventolin and xanthines (theophylline, etc.) increases the risk of developing tachyarrhythmias;
  • while taking salbutamol with anticholinergic agents (including inhalation forms), intraocular pressure may increase;
  • The hypokalemic effect of salbutamol is enhanced when used simultaneously with diuretics, glucocorticosteroids.

Pregnancy and lactation

During pregnancy, Ventolin is prescribed only in situations where the expected benefit to the mother exceeds the potential threat to the fetus. Rarely, the use of Ventolin by a pregnant woman caused the development of defects in the child (impaired development of the extremities, "cleft palate"). However, in these cases, the patient along with Ventolin took other drugs. Accordingly, accurate data on the effects of Ventolin on the fetus are not available.

Ventolin gets into breast milk. There are no exact data on the effects of salbutamol on the body of a breastfed baby. Therefore, the drug is not recommended for use during lactation. If necessary, treatment with aerosol is required to stop breastfeeding.

Ventolin analogues

The complete structural analogues of Ventolin containing salbutamol are the following drugs: Salamol Eco light breathing, Salbutamol, Tebu Salbutamol, Astalin.

Terms and conditions of storage

Ventolin inhalation aerosol is stored protected from direct sunlight, out of the reach of children. The optimum temperature is up to 30 ° C, the drug should not be frozen. The shelf life of the aerosol is 2 years. Do not use the drug after the expiration date indicated on the package.

Ventolin price

Ventolin aerosol for inhalation - 130-168 rubles.

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