The Ventolin Nebulas for inhalations: instructions, application for children, reviews, price
Medicine online

The

Ventolin Nebulas for inhalations: instructions

ATX-R03AC02 code

Pharmacotherapeutic group : selective b-2 adrenomimetic (a drug that selectively stimulates b-2 adrenergic receptors).

Dosage form : aerosol for inhalation.

Product : transparent colorless or light yellow liquid, polyethylene ampoules, aluminum foil bag, laminated with polyethylene, cardboard tutu.

Pharmacological properties

The drug, a selective antagonist of b2-adrenergic receptors, in therapeutic doses acting on b2 adrenoreceptors of smooth muscles of the bronchi.



Composition:

Active substance :

  • Salbutamol.

Auxiliary components :

  • sodium chloride;
  • Diluted sulfuric acid;
  • purified water.

Pharmacodynamics

The active ingredient of the drug for a long time has an inhibitory effect on histamine, prostaglandin D2, leukotrienes and other biologically active substances. It can suppress early and late bronchial activity. Has a pronounced bronchodilator effect, it stops or prevents the development of bronchospasm, increases the vital capacity of the lungs, reduces resistance in the respiratory tract. In chronic bronchitis, the mucociliary clearance increases by 36%, activates the function of the ciliated epithelium, stimulates the secretion of mucus.

Under the influence of salbutamol, the release of inflammatory mediators is inhibited, with the genetic predisposition to the disease, antigen-dependent suppression of mucociliary transport and the release of chemotaxis factors causing directional migration of inflammatory cells are eliminated. It is able to reduce the concentration of potassium in the blood plasma, affects the release of insulin and glycogenolysis, lipolytic and hyperglycemic effect, increases the risk of acidosis. Calls for the expansion of the coronary arteries, has a positive chronotropic and ionotropic effect.

Pharmacokinetics

After inhalation use, about 10-20% of the active ingredient reaches the airways. The rest of the solution remains in the delivery device, or settles on the walls of the nasopharynx, and then is swallowed. The dose reaching the airways is not metabolized in the lungs, but absorbed into the tissue of the respiratory organs and absorbed into the bloodstream. The drug begins to act 4-5 minutes after the inhalation procedure (maximum - after 30-90 minutes). The duration of action is 4-6 hours. Absorbed into the systemic circulation, Ventolin Nebula is metabolized in the liver. It is released in the form of a phenol sulfate metabolite and unchanged. 69-90% is excreted by the kidneys, 4% by the intestines, together with bile. The maximum dose is displayed within 72 hours.

The connection with plasma proteins is 10%. The active ingredient (salbutamol) is able to penetrate the placental barrier.


Indications for use

Bronchial asthma:

  • Relief of seizures;
  • Exacerbation and severe course of the disease;
  • Prevention of attacks of bronchospasm caused by physical exertion or exposure to an allergen;
  • As a complex treatment for long-term maintenance therapy.

COPD (chronic obstructive pulmonary disease)

  • Reversible airway obstruction;
  • Chronic bronchitis ;
  • Emphysema of the lungs.

Contraindications

  • Hypersensitivity to the components of the drug;
  • Threat of abortion;
  • Premature delivery;
  • Children under the age of 1.5 years.

Dosing and Administration

Ventolin Nebula is a preparation for inhalation. Its use involves the use of a nebulizer (a special inhaler equipped with a mask and an endotracheal tube). For medical reasons, artificial ventilation with alternating positive pressure may be used. If there is a risk of hypoxia, which is a consequence of hypoventilation, the inhaled air is enriched with oxygen.

The drug for inhalations is used in undiluted form. However, with prolonged administration (more than 10 minutes), it is recommended to dilute it with sterile saline. The solution remaining in the nebulizer chamber should be poured out at the end of the procedure. Inhalation should be carried out in well-ventilated areas.

The average initial dose of the drug for adults and children is 2.5 mg. If necessary, it can be increased to 5 mg. Inhalation is recommended 4 times a day. For patients with severe airway obstruction, the dose may be increased to 40 mg per day. In this situation, procedures should be performed under strict medical supervision, in a stationary setting.

During pregnancy and lactation, Ventolin Nebula is indicated for use only if the expected benefit from its use exceeds the risk of exposure to the fetus.

In connection with the fact that there are data on the possibility of salbutamol penetration into breast milk, it is not recommended to perform inhalations during lactation. An exception is also the case when the expected benefit for the mother exceeds the potential risk for the child.

Side effect

  • Light tremor of skeletal muscles (especially of the hands);
  • Headache;
  • Slight increase in heart rate;
  • Expansion of peripheral vessels;
  • Tachycardia ;
  • Muscle cramps ;
  • Skin reactions (flushing of the skin, itching, hives , angioedema);
  • Arterial hypotension, collapse (in very rare cases);
  • Parodoxical bronchospasm;
  • Hypokalemia;
  • Increased motor activity and mental arousal (in children);
  • Extrasystolia, subventricular tachycardia, atrial fibrillation (in patients with a predisposition).

Drug Interactions

Ventolin Nebula is not recommended for use in combination with MAOI (monoamine oxidase inhibitors) and with nonselective b-adrenergic blockers.

Overdose

The most characteristic symptoms of an overdose of an active ingredient include metabolic disorders, tremor of the upper extremities, hyperactivity, hypoglycemia, tachycardia. In rare cases, the development of lactic acidosis is possible.

Leave conditions

Refers to prescription drugs.

Storage conditions

Store in a dry place, protected from light, out of reach of children, at a temperature not exceeding 30 ° C.

Shelf life

Shelf life of the drug is 3 years from the date of issue. After the expiry date indicated on the package, the drug should not be used. After opening the aluminum piling, store no more than 3 months.

Average price in pharmacies in Moscow

From 280. 00 rubles.

Ventolin Nebula analogues

  • The fan;
  • Ventolin Evohaler;
  • Nebutamol;
  • Salamol-Steri-Neb;
  • Salbutamol;
  • Salamol Eco light breath.
Estimate Ventolin Nebula on a 5-point scale:
1 звезда2 звезды3 звезды4 звезды5 звезд (Votes: 1 , average rating: 5.00 of 5)


Reviews about the drug Ventolin Nebula:

The
Leave your feedback
    The
    The