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Vazaprostan instructions for use

The drug Vazaprostan is a drug that has a pronounced antiaggregatory and vasodilating effects and is prescribed to patients for the treatment of obliterating diseases of large blood vessels.

Release form and composition of the drug

The drug Vazaprostan is produced in the form of a lyophysiate intended for the preparation of a solution for intravenous infusions. The drug is a hygroscopic white mass, packed in glass ampoules of 10 pieces in a cardboard box.

The main active ingredient of the drug is alprostadil 20 or 60 μg, as well as auxiliary components.

Pharmacological properties of the drug

Vazaprostan when released into the general bloodstream has a vasoprotective effect on the blood vessels, helps to improve microcirculation and peripheral circulation. It has a vasodilating effect, helps to relax smooth muscles and reflexively increases cardiac output and heart rate. Due to the components contained in the preparation, platelet aggregation is reduced, fibrinolytic function of the blood increases. The active ingredient of the drug slightly inhibits the secretion of gastric juice and hydrochloric acid.

Indications for use

The drug is prescribed to patients for the treatment and prevention of exacerbations of chronic obliterating diseases of arteries 3 and 4 stages.

Contraindications

According to the instructions, the drug has a number of contraindications, which include:

  • Heart rhythm disorders;
  • Coronary artery disease in the acute stage;
  • Chronic heart failure in the stage of decompensation;
  • A history of myocardial infarction in the past six months;
  • Severe liver and kidney function;
  • Increased liver transaminases;
  • Lung disease with marked impairment of respiratory function;
  • Individual intolerance to the components of the drug;
  • Tendency to internal bleeding - with gastric ulcer and duodenal ulcer, atherosclerosis of the cerebral arteries, retinopathy, multiple injuries;
  • Pregnancy and lactation.

With special care, the drug should be prescribed to patients with hypertension, patients on hemodialysis of the kidney, patients with diabetes and cardiovascular insufficiency.


Dosage and administration

Vazaprostan solution must be prepared immediately before the introduction into the bloodstream. It is completely unacceptable to store the solution until the next infusion.

For introduction into the arteries, the contents of the ampoule are diluted with 20 µg in 50 ml of isotonic sodium solution. Depending on the indications, the initial dose of the drug is half the ampoule, which is administered intraarterially for 1-2 hours using a special device for infusion. If necessary, depending on the indications, the dose is increased to the whole ampoule (in this case the doctor strictly controls the patient's condition). The whole ampoule of the drug, as a rule, can be administered only once.

When intra-arterial injection of this drug through an installed catheter, depending on the diagnosis and the individual characteristics of the body, prescribe a dose of 0.1-0.6 ng / kg per minute. This infusion is carried out for about 12 hours using a special device for infusion.

With the introduction of the drug intravenously, use 2 ampoules of the drug at 20 μg, which are previously dissolved in 50-250 ml of isotonic sodium solution and continue to be infused for 2 hours 2 times a day.

According to the instructions, the duration of drug therapy is on average at least 2 weeks. In case of insufficient effect or neglected state of the patient, the therapy can be extended for another 1-2 weeks as directed by the doctor. Patients with renal and heart failure require individual dose adjustment.

Use of the drug during pregnancy and lactation

This drug is not used to treat pregnant women due to the lack of reliable data on the safety of the active substance on the fetus.

If necessary, treatment with Vazaprostan during lactation should first decide on the termination of breastfeeding.

The drug is also not used in pediatric practice and for the treatment of adolescents under 18 years of age.

Side effects

During the period of treatment with this drug, the patient may experience the following side effects:

  • From the nervous system - headaches, convulsions , increasing weakness, dizziness, fatigue, paresthesias;
  • On the part of the heart and blood vessels, a change in heart rate, a decrease in blood pressure, pain in the region of the heart
  • On the part of the musculoskeletal system - hyperstasis of long tubular bones;
  • From the side of the digestive canal - pain in the stomach, nausea and vomiting, diarrhea;
  • Perhaps the development of allergic reactions in the form of skin rash, redness, itching, swelling of the mucous membranes and skin, pain along the vein;
  • Increased sweating;
  • Increased body temperature;
  • Changes in the clinical picture of the blood - reducing the number of leukocytes, increasing the level of hepatic transaminases, C-reactive protein;
  • In rare cases, the development of pain in the joints, confusion, slowing respiratory movements, anuria.

In case of severe drug overdose, the patient develops acute heart failure, impaired renal function, ventricular fibrillation.

In most cases, all side effects disappear after lowering the drug dose or discontinuing therapy.


special instructions

This drug can be prescribed only by order of the doctor! During the treatment period, patients are constantly monitored for their blood pressure, biochemical blood counts, and heart rate.

To prevent a violation of the blood coagulation function, this drug is not prescribed simultaneously with drugs from the group of anticoagulants or nonsteroidal anti-inflammatory drugs.

In order to prevent the state of hyperhydration in patients with renal insufficiency, the volume of fluid injected into the bloodstream should not exceed 50-100 ml per day. If necessary, the patient is monitored daily diuresis and ecocardiographic study.

Patients with diagnosed ischemic heart disease or renal failure after discontinuation of the drug for another day should remain in the hospital under the supervision of a physician.

The active ingredient of the drug Vazaprostan may influence the speed of reactions, therefore during the period of treatment with the drug it is not recommended to drive a car or control the mechanisms requiring a quick response.

Against the background of treatment with this drug, it is strictly forbidden to drink alcoholic beverages.

Conditions of release and storage of the drug

Vazaprostan is sold in pharmacies without a prescription. The drug should be stored at a temperature not exceeding 25 degrees, away from children, avoiding direct sunlight. Shelf life is 4 years from the date of manufacture. At the expiration of this juice, the drug can no longer be used. If the ampoule is damaged, then it cannot be used to prepare the solution for infusion.

Vazaprostan Price

The average cost of Vazaprostan drug in pharmacies in Moscow is 8200-9300 rubles.

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