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Valdoksan instructions for use

The drug Valdoxan is a drug from the group of psychoanaleptics (antidepressant), the therapeutic effect of which is aimed at normalizing the nervous system, eliminating depression and feelings of depression in the patient.

Release form and composition of the drug

The drug Valdoxan is available in the form of tablets for oral use covered with a protective film of orange color. The drug is packaged in blisters of 14 pieces in the cathonic boxes. Each box contains 1,2,7 blisters.

Each tablet contains the active active ingredient agomelatine in the amount of 25 mg, as well as a number of auxiliary components: magnesium stearate, silicon dioxide, cellulose, lactose, povidone.

Pharmacological properties of the drug

Tablets are intended for ingestion. After entering the gastrointestinal tract, the active active ingredients are rapidly absorbed through its mucous membranes into the common bloodstream. Under the influence of the drug in patients disappears feeling of fear, depression, depression. During therapy with this drug, patients normalize sleep, suppress aggressiveness and irritability, improve mood and general well-being.

While taking the drug in patients, there is no change in blood pressure and heart rate. After the end of the course of therapy, patients do not develop withdrawal syndrome, that is, there is no need to cancel the drug gradually, reducing the dosage.

During treatment with Valdoxan, patients do not get addicted, and the active active components of the pill do not suppress sexual function, like many other drugs in this group.

Indications for use

This drug is prescribed to adult patients for the treatment of serious psychological disorders and protracted depression.


The drug Valdoxan is not prescribed for the treatment of mental disorders in patients with these conditions:

  • Severe damage to the liver or kidneys in the active phase;
  • Patient age up to 18 years;
  • Aggressiveness, hostility towards others;
  • Suicidal tendencies;
  • Conflict, or, conversely, alienation to others;
  • Individual intolerance to the active components of the tablet;
  • Lactase deficiency, galactosemia;
  • Renal failure;
  • Affective insanity;
  • Chronic alcoholism or treatment with other drugs that have a detrimental effect on the liver.

Dosage and administration

The dose of the drug and the duration of the course of therapy should be calculated only by the doctor strictly for each individual patient.

According to the instructions for the drug Valdoxan tablets should be taken orally, regardless of the meal, not chewing and crushing. It is necessary to wash down a tablet with enough liquid.

The recommended dose is 25 mg per day 1 time. The drug is taken more often at night, since the ingredients in the tablet can cause drowsiness in the patient. If during 14 days from the beginning of the course of therapy, the patient does not experience positive dynamics, then he should consult the doctor again, in some cases it is advisable to increase the recommended dose by half, dividing it into 2 doses.

With an increase in the dose of the drug and during treatment with Valdoxan, the patient should constantly monitor indicators of hepatic transaminases and general health, including tolerability.

According to the instructions, depending on the indications and severity of clinical symptoms of the disease, the duration of the course of drug therapy is about six months, after which you must take a break.

Elderly patients require dose adjustment of the drug in order to prevent the development of side effects.

Use during pregnancy and lactation

In medicine, there is no reliable data on the safety of the active components of the drug on the development of the fetus and the course of pregnancy in women. Studies that were carried out on animals did not reveal the teratogenic effect of agomelatine on the intrauterine development of the pups, nor did the born animals have any impairments or developmental delays. Despite this, for the purpose of safety and precaution, this drug is not prescribed for the treatment of pregnant women.

Regarding the use of Valdoxan during breastfeeding, there is no data on the ability of the main active ingredient to penetrate into breast milk, therefore, as a precaution, this drug is not prescribed for the treatment of nursing mothers. If, for any reason, treatment with Valdoxan is extremely necessary, the woman is advised to stop breastfeeding the baby and transfer it to the formula.

Side effects

In most cases, in many patients in the first 14 days from the start of the course of therapy, side effects on the drug were observed, which are the norm and, as a rule, do not require discontinuation of treatment. Side effects were as follows:

  • On the part of the digestive tract - nausea, constipation, and sometimes pain in the epigastric region;
  • On the part of the nervous system - dizziness, drowsiness or insomnia, headaches, in rare cases of paresthesia;
  • Increased sweating, tinnitus;
  • Pain in the lumbar region and general malaise;
  • Changes in the blood picture - an increase in hepatic transaminases, in rare cases the yellowness of the skin;
  • In rare cases with hypersensitivity, patients experienced the development of urticaria, pruritus, angioedema.

At first, on the background of the patient's medication, anxiety, anxiety, irritability, nightmares may disturb.

Interaction with other drugs

With simultaneous use of this drug with Rifampicin in patients, a decrease in the therapeutic effect of Valdoxan may be observed.

Patients who smoke or use alcoholic beverages systematically may notice a significant decrease in the therapeutic effect of the drug, in addition, the simultaneous use of antidepressants with alcohol can lead to serious liver damage and marked inhibition of the central nervous system.

special instructions

During the period of treatment with this drug, patients should regularly check the indicators of blood tests and monitor their overall health. With an increase in hepatic transaminases, it is recommended to repeat the blood test after 3 days, if the transaminase level continues to rise, then treatment with Valdoxan should be stopped.

When a patient has symptoms indicating liver dysfunction, such as jaundice, dark urine and discoloration of feces, pain in the right hypochondrium, jaundice of the eye sclera, drug therapy should be immediately stopped and the patient should be sent for a full examination.

With special care, tablets are prescribed to patients with diabetes mellitus, hypertension, obesity, and impaired liver function.

Conditions of release and storage of the drug

Valdoxan tablets are sold in pharmacies only by prescription of the attending physician. The shelf life of the drug is 3 years from the date of manufacture. It is recommended to keep the tablets away from children at a temperature not higher than 25 degrees.

Valdoksan price

The average cost of the drug Valdoxan in pharmacies in Moscow is 1600-1750 rubles per pack.

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