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Vagiferon instructions for use

The drug Vagiferon is a combination drug that exhibits a high therapeutic activity against infectious pathogens, viruses and fungi.

Release form and composition of the drug

The drug Vagiferon is available in the form of suppositories intended for vaginal administration. Each suppository contains recombinant human interferon 50,000 IU, fluconazole, metronidazole, and a number of auxiliary components. Each candle is packed in individual cells, the drug is sold in cardboard boxes of 5 and 10 suppositories.

Pharmacological properties of the drug

Vagiferon suppositories have a pronounced antiseptic, antifungal and anti-inflammatory effects. When injected into the vagina, the active active ingredients are slowly released, killing the pathogens, relieving the edema and symptoms of inflammation and increasing local immunity. The main active ingredients of the drug are highly therapeutic in relation to trichomonads, gonokokkam, chlamydia, herpes - as part of complex therapy with oral antibiotics or acyclovir.

Metronidazole, which is part of the suppository, is active in relation to gadrenella, triomonads, clostridia, Escherichia coli. Due to the activity of the drug, satellites of the inflammatory process such as itching and burning, abundant purulent or mucopurulent vaginal discharge, and discomfort in the perineal region quickly disappear in women.

Fluconazole, which is part of suppositories, is highly effective against pathogens of the fungal inflammatory process, in particular, Candida fungi, which multiply aggressively against the background of a general decrease in a woman’s immunity or prolonged use of antibiotics.

Indications for use

Suppositories of this drug are prescribed to women in such situations:

  • Treatment and prevention of bacterial vaginosis, occurring against the background of a general decrease in immunity, constant vaginal douching, a long course of antibiotics;
  • Vaginitis of bacterial origin;
  • Inflammatory processes of the mucous membrane of the vagina, due to the pathological reproduction of Trichomonas, cardrenella, mycoplasma, ureaplasma, chlamydia and others;
  • Vaginal candidiasis, poorly amenable to treatment with other drugs (as part of complex therapy with immunomodulators, probiotics, dietary correction).


Vagiferon suppositories have a number of contraindications, which include:

  • Individual intolerance to the components that make up the candle;
  • Pregnancy;
  • The age of the patient to 18 years.

The drug is also not used to treat girls who have not yet entered into intimate relationships.

Dosage and administration

Suppositories Vagiferon is inserted deep into the vagina while lying down. For an even distribution of the active ingredients, a woman is advised not to get up about 10 hours; therefore, it is better to administer the drug in the evening, before going to bed.

According to the instructions, adult women are prescribed 1 suppository 1 time per day intravaginally. Depending on the indications, the daily dose of the drug can be increased, but this is discussed with the doctor on a strictly individual basis. The duration of the course of therapy depends largely on the diagnosis, the severity of the disease, the presence of complications and comorbidities. According to the instructions, the standard course of drug treatment is 10 days, but it can be extended on the recommendation of a doctor.

During the period of drug treatment woman is recommended to use sanitary pads. It is not recommended to have sexual relations in the period of use of suppositories for the best therapeutic effect. If a woman has a sexually transmitted disease, then both partners must undergo treatment, otherwise the therapy will be ineffective.

The use of the drug during pregnancy and breastfeeding

This drug is not used to treat women while they are pregnant. In medicine, there is no reliable data on the absolute safety of the main active ingredients of suppositories on the fetus, therefore, therapy with this drug is not recommended.

The use of Vagiferon suppositories during breastfeeding is contraindicated. This is due to the fact that the active ingredients of the drug can penetrate into breast milk and then into the baby’s body. Causes severe liver dysfunction. If it is necessary to treat this drug during lactation, breastfeeding should be interrupted by replacing the mother’s milk with an adapted milk formula. After the end of the course of drug therapy, lactation can be resumed no earlier than after 2 days.

Side effects and drug overdose

As a rule, the drug is well tolerated by patients, but in some rare cases, when an individual is hypersensitive to the components of the suppository, a woman may develop the following side effects:

  • Local reactions - itching and burning after inserting a candle into the vagina, a sensation of heat;
  • Side effects caused by the action of metronidazole - in rare cases, allergic reactions on the skin, constipation, dizziness, nausea, abdominal pain, metallic taste in the mouth, dry mouth, anxiety and emotional instability;
  • Changes in the vaginal microflora against the background of prolonged uncontrolled use of the drug

With long-term drug treatment in a patient, a change in the clinical picture of the blood is possible, in particular, a decrease in the number of leukocytes.

Interaction with drugs

With the simultaneous use of suppositories of Vagiferon with oral preparations based on human interferon, their therapeutic effect is enhanced.

With a sexually transmitted disease in a woman caused by trichomonads, gonococci, chlamydia or herpes viruses, local treatment with candles alone is not enough. The patient should consult a doctor and undergo a comprehensive treatment of the disease.

Conditions of release and storage of the drug

Candles are sold in pharmacies without a doctor's prescription. The drug should be stored in the refrigerator for 2 years from the date of manufacture indicated on the package.

Vagiferon price

The average cost of the drug in pharmacies in Moscow is 355-360 rubles.

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