Candles from thrush
- Candles with thrush with natamycin
- Candles from thrush with clotrimazole
- Intravaginal suppositories with fluconazole
- Candles from thrush with nystatin
- Candles with ketoconazole
- Candles from yeast that contain iodine
- Candles of sertaconazole (Zalain)
- easy introduction of the suppository into the vagina and high effectiveness of the action of antifungal medicines, due to its deep penetration into the mucous membrane of the genital tract of the woman;
- rapid elimination of unpleasant symptoms (discomfort, itching, burning, soreness in sexual intercourse and curdled discharge) as a result of the destruction of the causative agent of the infectious process and the elimination of inflammation;
- the possibility of using certain types of candles for thrush in pregnant women and breastfeeding, which is associated with its directed antifungal and minimal systemic action on the organism of the future mother and fetus.
To date, the domestic pharmacy network offers a wide range of different antifungal vaginal suppositories for topical treatment of thrush, which are used for monotherapy of acute candidiasis and are part of a complex therapy with oral medicines for chronic or recurrent thrush, and severe forms of candidiasis. But it is important to remember that this is a very insidious and complex disease for treatment and only a doctor can determine which candles from thrush will be most effective in each specific case. This is due to the rapid development in the fungal agents of resistance (resistance) to drugs, so before starting treatment you need to undergo a complete examination that will help the specialist determine the type of pathogen, the sensitivity of fungi and the stability of this pathogen by the result of bacterial inoculation. The doctor will help determine predisposing factors that are specific to a particular patient and often contribute to the development and progression of candidiasis (hormonal imbalance, diet, concomitant somatic diseases, simultaneous administration of antifungal suppositories with other medications), and their elimination is often an additional positive aspect in the treatment of candidiasis.
It is also important to strictly adhere to the treatment regimens and dosages of antifungal medications prescribed by the doctor - often lowering the doses of these drugs often leads to activation of candida multiplication and the progression of the inflammatory process or the formation of L-form resistant to most antifungal drugs.
Currently, several pathogens of sexually transmitted infections ( mycoplasmosis , chlamydia , gonorrhea , trichomoniasis) and / or the development of bacterial vaginosis caused by E. coli, proteus, klebsial or development of gardnerellosis often occur. Therefore, depending on the intensity of the manifestation of the symptoms of the inflammatory process, treatment is differentiated by the course of therapy and the kind of suppositories or combined use with oral antifungal drugs or the addition of antibacterial and anti-inflammatory drugs.
Important points in the treatment of candidiasis is the simultaneous treatment of the sexual partner, who in most cases is an asymptomatic carrier of the pathogens of infection and re-infecting his partner after successfully curing the thrush (the effect of "ping-pong").
During therapy with vaginal suppositories from thrush it is necessary to refuse from sexual contacts or to use condoms. And also do not wear tight and / or synthetic underwear, observe the rules of intimate hygiene with a daily change of towels and linen, do not use perfumed or chemical fluids for intimate hygiene, pads and toilet paper, which worsens the condition of patients and promotes the progression of inflammation.
It is important to use high-quality medicines and, before their application, specify the expiration date, possible side effects, contraindications, the composition of this kind of candles from thrush (to exclude individual intolerance of the main or auxiliary components of the suppository).
Many patients actively practice various douching with thrush in most cases without the appointment of a doctor, which breaks the microflora of the vagina and provokes further progression of the disease.
It is important to remember that any manifestations of self-treatment in the development of this pathology will lead only to negative consequences:
- the formation of fungal resistance and the development of chronic recurrent candidiasis;
- violations of local immunity of the mucous genital tract;
- vaginal dysbiosis;
- progression of inflammation and the development of generalization of the process with foci in the intestines, mouth and other organs);
- attachment of other pathogenic pathogens (microorganisms, viruses, protozoa) or specific inflammatory processes;
- violation of the hormonal background;
- progression of concomitant somatic diseases.
Candles for treatment of thrush are divided:
- depending on their composition and the main active substance (suppositories with fluconazole, nystatin, clotrimazole);
- complex candles from thrush:
- Polinazine (neomycin, nystatin, polymyxin B)
- Terzhinan (ternidazole, prednisolone, neomycin, nystatin);
- depending on the contingent of patients:
a) candles permitted for use in pregnant and lactating women;
b) children's vaginal suppositories;
Candles with thrush with natamycin
(Pimafucin, Primafungin, Natamycin)
These are modern antifungal vaginal suppositories with the main active ingredient macrolide antibiotic polyene series - natamycin. The antifungal activity of these suppositories of Primafungin, Pimafucin and Nathanomycin is caused by active disruption of metabolic processes in the cell membranes of yeast fungi, which inhibits their growth and leads to the destruction of cell walls of pathogenic microorganisms.
Pimafucin is available in a convenient dosage form in the form of vaginal suppositories, acting locally in the genital tract of a woman. It is not contraindicated in pregnancy and lactation. But with the long and uncontrolled use of this drug, as well as other antibacterial drugs, it is possible to disrupt the normal microflora of the vagina and develop dysbacteriosis. Therefore, for effective treatment of candidiasis, you must adhere to treatment regimens, observing the dose, the duration of therapy and the frequency of admission.
With candidiasis vulvitis, vaginitis and vulvovaginitis, one suppository is prescribed for a course of three to six days. Suppositories are administered in a prone position, as deep as possible in the vagina at night.
In the case of a recurring course of pathological processes, the causative agent of which is Candida albicans, an additional drug is prescribed with Natanomycin orally to sanitize the focus of infection in the intestine and other organs. For treatment or prophylaxis of candidiasis, the partner uses a drug with Natanomycin in the form of a cream (Pimafucin, Nathanomycin).
Contraindications to the use of vaginal suppositories is the intolerance of macrolide antibiotics or natamycin or other auxiliary components of candles (adipic acid, hard fat, sorbitol).
Sometimes (in the first days of using the drug), there are side effects - nausea and diarrhea that go away on their own.
Candles from thrush with clotrimazole
(Clotrimazole, Candide B6, Kandibene, Antifungole, Candisol, Kanesten, Jenamazol 100)
Antifungal preparations for intravaginal use with an active active ingredient from the group of imidazole derivatives - clotrimazole. Under the influence of this drug, the structure and properties of the cell membrane of yeast-like fungi, which cause the development of thrush, change, which leads to the death of the pathogen. A wide range of action of these vaginal suppositories is used to treat inflammatory processes of the vagina, which are caused by several pathogenic pathogens or chronic forms of thrush (candidiasis vulvitis, vulvovaginitis), as well as for the sanation of the birth canal of women before childbirth.
To prevent the recurrence of thrush, treatment of the sexual part with the use of cream with clotrimazole is necessary.
Often, to increase the effectiveness of therapy for severe forms of thrush, the use of candles is combined with the simultaneous administration of a cream, solution or ointment with clotrimazole.
With trichomoniasis, the use of vaginal suppositories with clotrimazole and metronidazole is used.
The drug is contraindicated for use:
- with increased sensitivity to clotrimazole or auxiliary components of vaginal suppositories;
- in the menstrual period;
- at the initial stages of pregnancy.
Side effects can manifest as:
- local manifestations in the form of hyperemia, itching, burning or swelling of the mucosa, vaginal discharge and discomfort during sexual intercourse;
- allergic reactions;
- systemic disorders - abdominal pain, rapid urination, headache).
The effectiveness of intravaginal suppositories with clotrimazole decreases with simultaneous use of drugs with nystatin, amphotericin B and natamycin for the qualitative treatment of candidiasis with the simultaneous use of these drugs need correction of doses and duration of drug use.
Intravaginal suppositories with fluconazole
(Diflucan, Fluconazole, Flucostat, Mycosyst, Fork, Fucis, Tsiskan, Fluzak, Fungolon, Flunocorum Funzol, Nofung, Medaflyukon)
These are vaginal suppositories for the treatment of thrush caused by yeast-like fungi (Microsporum, Candida and Trichophyton).
Fluconazole is a triazole antifungal drug. Its mechanism of action is based on the violation of the synthesis of styrene in the cells of fungi, destroying them and causing their death.
Side effects when using vaginal suppositories with fluconazole may be manifested: spastic pain in the abdomen, flatulence (increased gas production), migraine headaches, lethargy, impaired coordination, changes in peripheral blood (thrombocytopenia, leukopenia, agranulocytosis). All these manifestations occur when the daily dose is exceeded, for prolonged and uncontrolled use of candles, or in patients with concomitant somatic pathology, elderly patients, and in children.
The use of drugs with fluconazole is contraindicated:
- with individual intolerance of candle components;
- at pregnancy in any term;
- with lactation (in connection with the possible manifestation of side effects in the baby in the form of severe flatulence, anxiety, lethargy and changes in peripheral blood);
- children up to three years of age;
- when used simultaneously with astemizole, cisapride and terfenadine;
- in diseases of the heart and vessels with atrial fibrillation and flutter of the ventricles.
With care, these intravaginal drugs are prescribed for functional and organic diseases of the liver and gallbladder (can cause hyperbilirubinemia, progression of hepatitis and the development of jaundice), with autoimmune diseases, in the elderly and senile.
Candles from thrush with nystatin
(Nystatin, Polizhinaks, Makmiror complex, Terzhinan)
This drug belongs to antifungal agents, which has fungistatic action against yeast-like fungi of the genus Candida. These are the most effective suppositories for chronic forms of candidiasis, due to the fact that fungi rarely develop resistance to the main components of vaginal suppositories that act locally on the mucous membrane of the vagina. Long-term use of drugs with nystatin may lead to impairment of the beneficial microflora of the vagina and dysbiosis may develop. Basically, these drugs are well tolerated by all patients and have no side effects.
Candles with nystatin are contraindicated:
- with individual intolerance to the components of candles (especially those having a complex composition);
- at pregnancy (in connection with possible development of defects at a fetus at long local application, or at application of complex preparations on early terms of pregnancy (Terzhinan) can cause changes of a hormonal background);
- with diseases of the digestive tract.
Candles with ketoconazole
These antifungal suppositories for topical use with ketonazole, a preparation from the group of imidazoledioxolane derivatives. It has a fungistatic and fungicidal action, which consists in changing the lipid composition of the fungal membrane with inhibition of ergosterol biosynthesis.
Candles with ketonazole are prescribed only after twelve weeks of pregnancy, due to the fact that they can cause pathological changes in the fetus of unformed organs and organ systems.
The course of treatment can last from three to ten days - the duration of treatment depends on the complexity of the pathological process.
Side effects occur rarely, but can manifest as dizziness, itching, irritation, burning in the vagina, rash or yellow discharge from the genital tract of the patient.
Candles from yeast that contain iodine
(Betadine, Iodoxide, Povidone-iodine)
These are suppositories with pronounced antiseptic properties and a broad spectrum of antimicrobial activity against bacteria, fungi of the genus Candida, protozoa and viruses. When contact with the mucous membranes during dissolution of suppositories, iodine is absorbed gradually, providing an effective antimicrobial effect, but practically not absorbed into the systemic bloodstream.
These drugs are widely used in acute and chronic vaginitis caused by mixed flora, with vaginal infections after treatment with antibiotics or steroid hormones and as preventive measures before diagnostic procedures or surgical interventions in the vagina.
Contraindications to the use of this group of intravaginal suppositories are:
- adenoma of the thyroid gland;
- individual intolerance to iodine preparations or suppository auxiliary components;
- kidney failure;
- pregnancy and lactation.
Candles of sertaconazole (Zalain)
Sertaconazole is an effective antifungal agent, a derivative of benzothiophene and imidazole. It has an active fungicidal and fungistatic action - inhibiting the synthesis of ergosterol and increasing the permeability of the cell membrane of the fungus, which leads to the death of a pathogenic agent - fungus or microorganism. Candles are used in the treatment of vaginosis caused by fungi of the genus Candida and gram-positive bacteria (strepto- and staphylococci).
Allowed for use during menstruation. In pregnancy and lactation can be prescribed only with constant monitoring of the physician at vital indications, in connection with the fact that studies of this drug have not been conducted.
Contraindications to the use of vaginal suppositories are hypersensitivity to their main or auxiliary components.
Side effects - itching and burning in the vagina, allergic reactions.
Before use, it is recommended that the external genital organs be washed with neutral soap.
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