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Methotrexate for rheumatoid arthritis

Methotrexate for rheumatoid arthritis

Methotrexate is a chemotherapy drug from the group of antimetabolites used to treat many types of malignant tumors, as well as rheumatoid arthritis. The drug is available in the form of tablets or solution for injection. For arthritis, preference is given to tablets, which can be replaced by subcutaneous injections in the presence of any diseases of the digestive system.

Methotrexate has a rapid effect on cell division, helps to stop the production of deoxyribonucleic acid in the body and eliminate rheumatoid factor, that is, it slows down the action of immunity cells aimed at destroying the cells of their own organism. Since the drug does not have anti-inflammatory and analgesic effects, it is prescribed in combination with other medicines that are safer for human health.

Exceeding the dose of the drug is dangerous to human life, as well as taking it without a proper appointment by a specialist. The dose of medication is calculated strictly individually, depending on the age, weight and general condition of the patient. The main purpose of his appointment in rheumatoid arthritis is to stop the process of destruction of joint tissue, leading to disability of the patient.

A weekly dose of the drug, as a rule, does not exceed 10 mg. The first positive results of treatment are noticeable already after 2-4 weeks from the beginning of its reception. Rheumatoid arthritis occurs chronically, Methotrexate can be prescribed both in the period of exacerbation, and in the period of remission of the disease. Usually, treatment begins immediately after an accurate diagnosis is established.

Contraindications to the use of the drug are: renal failure, HIV infection, tuberculosis , gastric ulcer , alcoholism, hypersensitivity to its components. Methotrexate is not prescribed during pregnancy, because it has a high toxicity that can have a strong negative impact on the development of the fetus. At the time of treatment should refuse to breastfeed or postpone treatment with the drug (as recommended by the doctor). In addition, during the reception of methotrexate in the conduct of active sex life, you should take safe contraceptives or choose another reliable method of contraception.

The drug has an extensive list of side effects, including the possibility of death, but its relatively small doses prescribed for rheumatoid arthritis are usually well tolerated by patients. The most common causes are stomatitis, nausea, loss of appetite, vomiting, decreased vision, headache, dizziness, anemia, chronic fatigue. The more serious consequences of drug treatment include the development of liver cirrhosis, decreased sexual desire, anemia. If ingested in excess of the dose should be immediately contact a specialist. To reduce the toxic effects of the drug on the body contributes to the intravenous administration of calcium folinata.

Taking Methotrexate tablets negatively affects the state of the liver, inhibits bone marrow cells that perform the function of blood production, as well as cells of the nervous system. However, with all medical prescriptions, the drug provides a long-term remission of rheumatoid arthritis, and its combination with other drugs, also prescribed to treat this disease, allows you to get rid of its main manifestations for months and even years.


| 22 December 2013 | | 961 | Joint diseases
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  • | Arina | 6th October 2015

    When taking methotrexate, one should not forget about its detrimental effect on the liver. Prevents the negative impact on the liver of folinic (non-folic!) Acid. Folic acid can cause complications.

Leave your feedback


shan hafiz: Be careful proverbs 14:15 says "The naive person believes every word, But the shrewd one ponders each step". Some will tell you that the effects of such drugs are minimal but do your RESEARCH.

Angel: Methotrexate: Lung infections, skin reactions, diarrhea, mouth sores, stomach pain, nausea, fatigue, headache, chills, you can get cancers from this drug, especially skin cancer. Weight gain and a long list of other side effects. I have RA and live without any drug. It's all diet and light exercise that helps. But the doctors don't tell you this. Doctors are simply not trained in side effects nor pain. I'd rather suffer it out and eat right. Epson bath salts help soothe joints. Do your research, not everything needs a drug.

DewaldFive: I am starting my Treatment in about 6 days to treat my Psoriasis....I am very nervous , but after seeing this video, I feel more at ease . Thanks

Roselyn Veado: After my ARTHRITIS of the spine and both knees diagnosis 5 years ago, symptoms started with severe back pain, stiffness and joint swelling, rigidity, tenderness, weakness in my knees and eventually the feeling spread to my shoulders and neck, i couldn’t lift my arm without pain medications. I was prescribed tramacet and arcoxia for 8 months but had to stop them due to the side effects. Last year, I started on OSTEOARTHRITIS HERBAL FORMULA from RICH HERBS FOUNDATION, the treatment worked incredibly for my arthritis condition. Visit ww w. richherbsfoundation. c om. This natural herbal treatment reversed my arthritis condition.

NICOSIADON: Am confused. i've been given HCQS, hydroxy chloroquin sulphate and folitrex-thats methotrexate and LFRA-thats Lefsulomide, am a PhD., in Microbiology and sufficiently have studied about the disease RA. I usually recommend treatment with herbs and ayurvedic preparations monitoring the blood counts, KFTs,and LFTs, but still after going thro' the side effects of Lefsulomide, am really scared. am taking 50 Mg of Diclofenac sodium in the night at 10pm and at 12.45am to kill the pain.

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