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Buserelin-Long: instructions for use

Release form

The drug is available in the form of a lyophilisate contained in a vial (capacity 10 ml), made of dark colored glass. A solvent is attached to the ampoule with which the suspension is prepared for intramuscular injection. In the carton is 1 ampoule and 1 solvent.


1 vial contains the main active ingredient - buserelin (in the amount of 3, 75 mg, in terms of buserelin acetate 3.93 mg) and auxiliary components:

  • Polysorbate 80 - 2 mg;
  • d-mannitol - 85 mg;
  • sodium carmesol - 30 mg;
  • glycolic and dl-lactic acid - 200 mg.

The solvent is mannitol (0.8% solution).

pharmachologic effect

The drug has the following effects on the body:

  • antiestrogenic;
  • antiandrogenic;
  • antitumor;
  • antigonadotropic.

Buserelin-Long is able to bind to receptors of cells located in the anterior lobe of the pituitary gland. And for two weeks is able to completely block its gonadotropic functions. Also, the drug is subject to the process of inhibition of follicle-stimulating and luteinizing hormones.

As a result of taking Buserelin-Long can be observed:

  • decrease in blood levels of estradiol up to post-menopausal indicators;
  • decrease in testosterone concentration in testicles;
  • suppression of sex hormones located in the ovaries.


  1. Infertility (during in vitro fertilization).
  2. The flow of hyperplastic processes in endometrial tissues.
  3. Uterine fibroids .
  4. Endometriosis (during periods before and after surgery).
  5. Breast cancer.
  6. Cancer (hormone-dependent) prostate.


  1. Periods of pregnancy and breastfeeding.
  2. The presence of individual intolerance to any of the components of the drug.

Possible side effects

Are common Among women In men
1. Pulmonary thromboembolism of unknown etiology (rare)

2. Dyspeptic manifestations (rarely)

3. Bone demineralization with an increased risk of osteoporosis

4. Manifestations of urticaria

5. Redness of the skin

1. Reduced libido

2. Pain in the abdominal cavity

3. Dryness of the vaginal mucosa

4. tides

5. Hyperhidrosis

6. Headaches

7. Frequent and drastic mood changes.

8. Sleep Disorder

9. Depression

10. Bloody vaginal discharge

1. Obstruction of the ureters (rare)

2. Pressure on the spinal cord (rare)

3. Reduced potency (this side effect sometimes requires the use of substitution therapy or the complete abolition of the drug)

4. Difficult urination

5. Weakness in the muscle tissues of the lower extremities

6. Puffiness (face, eyelids, legs)

7. Increased androgen levels in the blood.

8. Gynecomastia

9. Rush of blood to facial tissues.


Information about the cases of drug overdose has been reported.

Methods of administration and dosage

The drug is intended only for intramuscular administration. Preparation of suspension for injection should be carried out immediately before the introduction of the drug. There is a solvent in the package.

It is also worth recalling that a person with experience in carrying out such procedures should be involved in diluting the drug with a solvent and injecting the drug.

In the treatment of infertility (in the complex IVF)

The drug is administered in the amount of 3.75 mg before hyperstimulation on the 21-24th or on the 2nd day of the menstrual cycle. After the pituitary function becomes depressed (this is evidenced by a decrease in the level of estrogen in the blood serum, but hormones should not be less than 50%), patients are prescribed gonadotropic hormones.

This method of treatment should be carried out with the mandatory establishment of control over the level of estradiol and periodic ultrasound monitoring. Therapy with this drug can not be applied to patients who have ovarian cysts.

When treating uterine fibroids

A single dose of intramuscularly administered drug should not exceed 3.75 mg. Buserelin-Long is applied in the first 5 days of the menstrual cycle, followed by a four-week break. The course of treatment before surgery is 3 months, in any other cases - six months.

In the treatment of endometriosis and hyperplastic changes in endometrial tissues

The drug is administered at 3, 75 mg in the first 5 days of the menstrual cycle with an interval of one month. The therapeutic course should last from 4 to 6 months.

In the treatment of hormone-dependent prostate cancer

Buserelin-Long is injected at 3.75 mg by intramuscular injection 1 time per month. The course of treatment is determined at the discretion of the attending physician.

Special instructions table

Are common For women For men
Doing work that requires high concentration of attention, such as driving a car, is not recommended. 1. Functionality of the ovaries, after discontinuation of the drug, are restored after about 3 months

2. While taking Buserelin-Long, you should not use hormonal contraceptives.

3. Before using the drug should exclude the presence of pregnancy

4. If induction of ovulation is performed, it is necessary to strictly follow all the doctor's instructions.

5. If a depressive state is observed while taking the drug, the patient should be under the supervision of a physician.

In order to avoid the development of side effects that may occur mainly in the first phase of Buserelin-Long, it is recommended to take anti-androgenic drugs. They need to be taken 15 days before the start of therapy with Busererlin-Long and for the next 15 females after the start of therapy.

Pregnancy and breastfeeding

The drug is contraindicated.

Drug interactions

A high probability of developing such a syndrome as ovarian hyperstimulation occurs due to the simultaneous administration of Buserelin-Long and drugs that contain sex hormones.

Buserelin-Long has the ability to reduce the effect of hypoglycemic drugs.

Buserelin-Long analogues

  1. Buserelin acetate solution.
  2. Buserelin Depot.
  3. Buserelin FSintez.
  4. Buserelin.

Vacation conditions

The drug is released only upon presentation of the prescription form.

Terms and conditions of storage

Buserelin-Long is recommended to be stored in a dark place at a temperature of + 8 ° C to + 20 ° C.

Buserelin Long Price

Buserelin-Long FS powder, lyophilized for the preparation of an injection of 3.75 mg - 3700-4300 rubles.

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Lynsey Martini: ive been researching ivf recently and you are the first person i seen that has left the needle in for 5 seconds, is this so none seeps out on the pull out? or a diff reason?

IVF Mumma Vlogs: hey Awesome I hope IVF will give you your little miracle! I am hoping to video as much that goes on as possible with my IVF protocol (which is Long protocol with down regulation) Id be happy to try answer any of your questions if you have any :)

jessica daigle: hey, thanks for posting your videos!! we are about to start ivf. I am scared but am hopefully. We also were married on april 26th 2008!!!! best of luck to you

Sohrab Khan: The needles used in this vdo are 22 1/2 and 27 gz not 18 and 22 1/2 (for injecting the site). The vdo with your description is confusing. Thanks

Sarah Gibson: Finding your videos really helpful, just starting treatment following cancer had first injection today. Any tips for the next stages please let me know, and thank you for the videos 😊

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