Budenofalk instructions for use
Form of issue
The drug is available in the form of hard gelatin capsules in red. The contents of the capsules are opaque round pellets (pellets) having a white color. Capsules are packed in blisters of 10 pcs. in each, and then in cardboard boxes. Each box can contain 1 pc., 5 pcs. or 10 pcs. blisters.
In one capsule Budenofalk contains budesonide in the amount of 3 g.
- sodium lauryl sulfate;
- red iron oxide;
- red cochineal A;
- titanium dioxide;
- purified water;
- dibutyl phthalate;
- eudrojit (RL, RS, S, L);
- Pavidone K25;
- lactose monohydrate;
- sugar granules, 20% consisting of cornstarch and 80% of sucrose.
This drug is taken orally to treat Crohn's disease. Budenofalk has the following effects on the body:
The mechanism of action of the drug is determined by:
- suppression and redistribution of inflammatory cells that migrate;
- a decrease in the number of mediators produced by mast cells;
- inhibition of inflammatory processes.
One of the specific mechanisms of action of the main active substance of the drug (budesonide) is the induction of proteins (some). These proteins inhibit phospholipase A2. They take part in the metabolic processes of arachidonic acid. This ensures the prevention of the development of foci of inflammation in prostaglandins and leukotrienes.
In connection with the fact that the process of induction of protein synthesis will take some time, and the therapeutic effect of the drug will manifest gradually. The maximum degree of therapeutic effect is observed after 10-15 days after the start of the drug. Due to the great similarity of budesonide to receptors, Budenofalk is able to provide targeted local action.
Inhalational use of Budenofalk allows you to suppress bronchial obstruction. During the admission of Budenofalk improves respiratory functions, as well as decreases the frequency and degree of intensity:
- attacks of suffocation;
- Shortness of breath.
Crohn's disease, occurring in a moderate or mild form with involvement of the ascending colonic and / or ileum in the pathological process.
- Functional disorders of the liver.
- Infectious diseases of the intestines of bacterial, fungal, viral or amoebic etiology.
- Individual intolerance to the body Budesonide or other ingredients that make up Budenofalk.
Table of possible side effects
|From the side||Symptomatic manifestations|
|The immune system||The risk of developing infectious diseases (the effect of the immune response)|
|Of cardio-vascular system|| Vasculitis
Increased blood pressure
|Endocrine system|| Imbalance of sex hormones (impotence, hirsutism, amenorrhea )
Atrophy or decreased function of the adrenal cortex
Swelling due to sodium retention in the body
Reducing the degree of glucose tolerance
|Organs of vision|| Cataract
|Musculoskeletal System|| Aseptic necrosis of femur and humerus (head)
|Skin covers|| Contact dermatitis
Reduced speed and quality of wound healing
Feeling of euphoria
It is also worth noting that the occurrence of adverse events depends on the individual sensitivity of the organism to the components of the drug, the intake of other SCS (the preceding and concomitant), the duration of therapy and the doses taken.
Cases of overdoses are not fixed. If you take into account the properties of the main active substance of the drug (budesonide), an overdose with the development of toxic manifestations is unlikely.
Dosage and route of administration
The drug is taken on 3 capsules (3 g each) per day - in the morning, afternoon and evening. The maximum daily dose is 9 g. The drug should preferably be taken 15-20 minutes before meals, washed down with a sufficient amount of water. If you swallow a capsule hard, you can open it and take the contents (granular powder), also with water. The method does not affect the effect of the drug. The course of treatment in most cases is 2 months. Reception Budenofalka can not be abruptly abolished, you need to gradually reduce the dose.
With special attention, with the appointment of the drug, you need to treat patients suffering from such pathologies:
If the patient suffers from measles or chicken pox, taking Budenofalk can complicate the course of these diseases. And if the patient is infected with these diseases during the treatment with Budenofalk, it is necessary to take a course of therapy with appropriate immunoglobulins. And as for the disease of chickenpox, it may be necessary to take antiviral drugs.
If the patient is prepared for surgery or some other stressful procedure for the body, the systemic use of GCS is necessary.
During pregnancy (especially in the first trimester) with the appointment of Budenofalk, the doctor must take into account the possible risk of complications, comparing it with the effect of therapy with the drug. That is, the ratio of these two aspects must be taken into account.
If the drug is prescribed to women who are in reproductive age, the doctor must exclude pregnancy. And women, during treatment with Budenofalk, should take contraceptives.
During lactation, taking the drug is unacceptable, as it is unclear whether it can penetrate into breast milk and influence its composition.
The use of the drug is contraindicated in the presence of functional disorders of the liver.
If you simultaneously take Budenofalk and Cimetidine, the level of budesonide (the main active ingredient Budenofalk) in the liquid component of the blood may slightly increase. However, this process will not have a significant clinical significance.
Strengthen the effect of Budenofalk can the following drugs that are part of the group of cytochrome P450 inhibitors:
Hypokalemia may worsen with the simultaneous administration of Budenofalk and saluretics.
Cardiac glycosides, with simultaneous administration with Budenofalk, can intensify their action due to the lack of insufficient potassium.
As for antacids and resins (eg, Kolestyramin), which have the ability to bind steroids, their combination with Budenofalk can weaken the effect of budesonide. Because of this, the interval between Budenofalk and the above means should be at least 2 hours.
The drug is sold in pharmacies only on presentation of the prescription.
Term and conditions of storage
Store Budenofalk at a temperature not exceeding 25 ° C and in a place that is inaccessible to children. Shelf life - 3 years.
Budenofalk capsules 3 mg, 20 pieces - 2500-3400 rubles.