The Bromhexine 4 Berlin-Chemie user's manual, price, reviews, analogues of syrup Bromhexine
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Bromhexin 4 Berlin-Chemie user manual

The solution has a medicinal property due to the ability to affect the viscous viscous consistency in the bronchi. Quickly digested after use, has pronounced mucolytic and expectorant actions. Half an hour after oral administration, it is absorbed by 99% in the organs of the gastrointestinal tract. Bioavailability of the main component is within 80%. It binds to plasma proteins by 99%. Bromgexin penetrates both blood-brain and placental barriers. The term half-life is about 16 hours. If a patient who has been prescribed bromhexine therapy has liver disease in severe manifestations, the half-life may significantly increase.

Form of issue and composition

The active ingredient is bromhexine hydrochloride. For 5 ml of the solution, its concentration is 4 mg, for 100 ml - 80 mg. The drug is released in the form of a solution that has the aroma of apricot. The solution has no color, a transparent, viscous consistency. This medicament also contains auxiliary elements: propylene glycol, aromatic additive "apricot", purified water, sorbitol and hydrochloric acid in the form of 0.1 M solution. The drug is used inside. The manufacturer produces a solution of Bromhexine 4 Berlin-Chemie in 100 and 60 ml vials. The bottles are made of dark glass and packed in cardboard boxes. One individual cardboard container contains 1 bottle, instruction and a spoon for precise dosing. The screw cap on the vial is made of plastic, has an aluminum stopper with a sealing rubber band. Both the vial and the secondary carton contain data on the production series and the period after which the receipt of the funds is not allowed.

Indications for use

The main indications are:

  • Diseases of the lungs and bronchi in both chronic and acute manifestations;
  • Tuberculosis;
  • Bronchitis obstructive;
  • Pneumonia;
  • In the therapy of bronchial asthma;
  • Tracheobronchitis;
  • Cystic fibrosis;
  • Treatment of emphysema;
  • Bronchiectasis, pneumoconiosis.


Bromhexine 4 Berlin-Chemie in solution should not be used in any sensitivity reactions to it or to auxiliary components. In addition, do not prescribe this remedy for such diseases and conditions:

  • Ulcerative disease, especially in the stage of its aggravation;
  • Pregnancy in the first trimester;
  • lactation.

With maximum caution, the drug should be administered with known liver and kidney pathologies, the presence of bleeding in the gastrointestinal tract, diseases with increased secretion in the bronchi and in children up to the age of two.

Dosing and Administration

The solution should be taken orally. In adults and adolescents from the age of 14 the required dose is from 2 to 4 measuring spoons three times throughout the day. Thus, for this group of people, the dose of bromhexine per day is from 24 to 48 mg.

Children whose body weight is not more than 50 kilograms, and the age varies from 6 to 14 years, the recommended dosage is 1 to 2 measuring spoons three times per 24 hours (12 to 24 mg of active ingredient per day).

To small patients up to 6 years of age, one measuring spoon is prescribed three times a day (12 mg of bromhexine, respectively).

To enhance the secretionolytic effect on the body in parallel assigned an additional elevated water regime.

Bromhexine 4 Berlin-Chemie can not be used for more than 5 days without prior consultation of a physician.

Side effects

In the treatment of bromhexine, there is a possibility of developing dyspeptic conditions. Sometimes there is a feeling of nausea, exacerbation of peptic ulcer, there are episodes of vomiting.

There were rare cases of allergic manifestations in the form of edema, rashes on the skin, and a runny nose. Individual reactions with fever, chills, headache, sudden dizziness, anaphylactic shock were recorded. In the blood picture, the level of transaminases may increase. In patients with hepatic disease, it is important to observe blood biochemistry, especially when there is a need for a long curative course.

In patients who do not tolerate sorbitol or fructose, it is very likely the development of nausea with vomiting, diarrhea, hypoglycemic reactions. Sometimes there are changes in the biochemical parameters of the blood.

In case of any adverse events, the medication should be stopped immediately and consult a specialist to change the treatment strategy.

special instructions

When using the drug is extremely important to take an increased amount of fluid, which has beneficial effects on the secretion activity of bromhexine, that is, improves the expectorant capacity.

If the patient is likely to develop bronchial motor disorders or sputum accumulates in large amounts, then bromhexine therapy should be performed with increased caution because of the possibility of delayed sputum excretion.

In pediatrics, treatment with this medication of patients under the age of 2 years is strictly under medical supervision. The composition of the drug is propylene glycol. This substance is capable of causing symptoms characteristic of the symptoms of alcohol intake. Admission to this age group is not recommended.

Important information for patients with a history of diabetes mellitus: 1 gram of the drug solution (in 5 milliliters) contains 2 grams of sorbitol (corresponding to 0.5 g of fructose) - the equivalent of 0.17 bread units.

The term half-elimination of the main active ingredient from the patient's body can change upwards in the presence of problems with the urinary system. In such patients, the dose of bromhexine either decreases or lengthens the gaps between the recommended frequency of admission.

With a variety of liver diseases, Bromhexin 4 Berlin-Chemie is administered with caution. If a long course is required, the blood indicators are periodically monitored. Sometimes it is necessary to adjust the dose or frequency of taking the drug.

Intolerance to fructose does not allow the appointment of bromhexine in the form of a solution.

Sorbitol, which is a part of, sometimes causes a weakly pronounced laxative effect.

Bromhexine easily penetrates the milk of lactating women. When lactation is not acceptable.

There are no data on the application during the period of gestation. You can not prescribe bromhexine therapy in the first trimester. In the remaining time the risk-benefit ratio is carefully estimated.

Bromhexine 4 Berlin-Chemie analogues

On sale, you can find the drug Bromhexine in solution, manufactured by many pharmaceutical companies. The dosage of the main component should be considered. Replacement of this medication is carried out by the attending physician.

Terms and conditions of storage

Specific storage conditions Bromhexine 4 Berlin-Chemie does not require a solution. Must be stored in the factory container strictly away from children, preferably at temperature values ​​not exceeding 25 degrees. The term storage is 3 years. If the therapy has been started and the integrity of the vial has been opened, its contents can be stored for 3 months. After the end of this period, admission is not allowed. From drug stores, the drug is dispensed without a prescription.

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