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Bromhexine 4 Berlin-Chemie instructions for use

The solution has a healing property due to its ability to affect the sputum of a viscous consistency in the bronchi. Quickly absorbed after application, has pronounced mucolytic and expectorant actions. Half an hour after oral administration, it is absorbed by 99% in the organs of the gastrointestinal tract. The bioavailability of the main component is within 80%. Associated with plasma proteins by 99%. Bromhexin penetrates both through the blood-brain and placental barriers. The term half-life is about 16 hours. If a patient who was prescribed Bromhexine therapy has liver disease in severe manifestations, then the half-life may increase significantly.

Release form and composition

The active main ingredient is bromhexine hydrochloride. At 5 ml of the solution its concentration is 4 mg, per 100 ml - 80 mg. Released drug in the form of a solution with apricot flavor. The solution has no color, transparent, viscous consistency. The composition of this drug also has auxiliary elements: propylene glycol, aromatic additive "apricot", purified water, sorbitol and hydrochloric acid in the form of a solution of 0.1 M. The drug is used inside. The manufacturer produces a solution of Bromhexin 4 Berlin-Chemie in bottles of 100 and 60 ml. The bottles are made of dark glass and packed in cardboard boxes. One individual carton contains 1 bottle, instruction and a spoon for accurate dosing. Screw cap on the bottle is made of plastic, has an aluminum cap with a sealing rubber. Both on a bottle, and on a secondary cardboard container there is data about a series of production and the term after which reception of means is not allowed.

Indications for use

The main indications include:

  • diseases of the lungs and bronchi in both chronic and acute manifestations;
  • tuberculous disease;
  • obstructive bronchitis ;
  • pneumonia;
  • in the treatment of bronchial asthma;
  • tracheobronchitis;
  • cystic fibrosis;
  • treatment of emphysema;
  • bronchiectasis, pneumoconiosis.


Bromhexin 4 Berlin-Chemie in solution should not be used in any sensitivity reactions to it or to auxiliary components. In addition, this drug should not be prescribed for such diseases and conditions:

  • peptic ulcer disease, especially in its acute stage;
  • first trimester pregnancy;
  • lactation.

With extreme caution, the drug should be prescribed for known pathologies of the liver and kidneys, the presence of bleeding in the gastrointestinal tract, diseases with an increased secretion in the bronchi and in children under two years of age.

Dosing and Administration

The solution should be taken orally. In adults and adolescents from the age of 14, the required dose ranges from 2 to 4 scoops three times during the day. Thus, for this group of people, the dose of Bromhexine per day is from 24 to 48 mg.

For children whose body weight is not more than 50 kilograms, and their age varies from 6 to 14 years, the recommended dosage is from 1 to 2 measuring spoons three times in 24 hours (from 12 to 24 mg of the active ingredient per day).

Small patients under 6 years of age are given 1 scoop three times a day (12 mg of bromhexine, respectively).

To enhance the secretolytic effect on the body, in parallel, an additional increased water regime is prescribed.

Bromhexin 4 Berlin-Chemie can not be used for more than 5 - day period without first consulting a doctor.

Side effects

When treating with Bromhexine, there is a likelihood of dyspeptic conditions. Sometimes there is a feeling of nausea, aggravation of peptic ulcer, there are episodes of vomiting.

There have been rare cases of allergic manifestations in the form of edema, skin rash, runny nose. Individual reactions were recorded with fever, chills, headache, sudden dizziness, and anaphylactic shock. In the blood picture, transaminase levels may increase. In patients with hepatic diseases, it is important to observe blood biochemistry, especially when there is a need for a long treatment course.

In patients who do not tolerate sorbitol or fructose, nausea with vomiting, diarrhea, and hypoglycemic reactions is very likely. Sometimes there are changes in the biochemical parameters of blood.

For any adverse events, the medication should be stopped immediately and contact the attending specialist to change the treatment strategy.

special instructions

When using the drug is extremely important to take an increased amount of fluid, which has a beneficial effect on the secretolytic activity of Bromhexine, that is, improves the expectorant ability.

If the patient is likely to develop bronchial motility disorders or sputum accumulates in large quantities, then Bromhexine therapy should be carried out with increased caution because of the possibility of delayed sputum removal.

In pediatrics, treatment with this drug by patients under the age of 2 years is carried out strictly under medical supervision. In the composition of the drug is propylene glycol. This substance can cause symptoms characteristic of the symptoms of alcohol intake. Reception means this age group is not recommended.

Important information for patients with a diagnosis of diabetes mellitus in history: 1 measuring spoon of the drug solution (5 ml) contains 2 grams of sorbitol (corresponding to 0.5 g of fructose) - the equivalent of 0.17 bread units.

The term “half-life” of the main active ingredient from the patient's body may change upwards if he has problems with the urinary system. In such patients, the dose of Bromhexine is either reduced or lengthened by the intervals between the recommended frequency of administration.

In a variety of liver diseases, Bromhexine 4 Berlin-Chemie is prescribed with increased caution. If a long course is required, blood parameters are monitored periodically. Sometimes a dose or frequency adjustment is required.

Fructose intolerance does not allow the appointment of bromhexine in the form of a solution.

Sorbitol, which is a part, sometimes causes a dull laxative effect.

Bromhexine easily penetrates into the milk of lactating women. During lactation, intake is not allowed.

Data on the application in the period of carrying a child there. You can not prescribe therapy with Bromhexine in the first trimester. In the remaining periods, the risk-benefit ratio is carefully evaluated.

Bromhexin 4 Berlin-Chemie analogues

On sale you can find the drug Bromhexin in solution, produced by many pharmaceutical companies. You should consider the dosage of the main component. The replacement of this drug is carried out by the attending physician.

Terms and conditions of storage

Bromhexin 4 Berlin-Chemie does not require specific storage conditions. Must be stored in the factory packaging strictly away from children, preferably at temperature indices not exceeding 25 degrees. Storage term is 3 years. If the therapy was started and the integrity of the bottle was opened, its contents can be stored for 3 months. After this deadline, admission is not allowed. From pharmacies drug over the counter.

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