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Bonviva instructions for use

Bonviva tablets are representative of the pharmacological group of drugs - inhibitors of bone tissue resorption. The drug is used to prevent bone fractures in the postmenopausal period.

Release form and composition

Bonviva drug is available in coated tablets. One tablet contains the active ingredient ibandronic acid in the amount of 150 mg. Also contains excipients, which include:

  • Lactose monohydrate.
  • Microcrystalline cellulose.
  • Povidone 25.
  • Crospovidone.
  • Stearic acid.
  • Silica colloidal anhydrous.
  • Tatana dioxide.
  • Hypromellose.
  • Macrogol 6000.
  • Talc.

The tablets are packaged in a blister of 14 pieces each, a carton pack contains 2 blisters (28 tablets) and instructions for use of the drug.

pharmachologic effect

The main active ingredient of the drug is ibandronic acid. It is a highly active nitrogen-containing bisphosphonate. Ibandronic acid inhibits (inhibits) the process of resorption (resorption, followed by a decrease in the relative density) of bone tissue. It also reduces the activity of osteoclast cells responsible for bone resorption. Such a pharmacological effect of the drug is possible due to a certain chemical similarity of the active substance, it combines with hydroxyapatite, which forms the basis of the mineral matrix of bone tissue. Ibandronic acid, depending on the concentration, inhibits bone resorption and demineralization (decrease in the concentration of mineral salts). It has a number of therapeutic effects:

  • It promotes a progressive increase in bone mass (especially in postmenopausal women, which is accompanied by changes in the hormonal balance and an increase in the leaching of minerals from the bone tissue).
  • Inhibits bone resorption, without affecting other processes of osteogenesis (bone formation).
  • In postmenopausal women, it activates metabolic processes in the bone tissue, leading them to the level of reproductive age.

Also, ibandronic acid primarily affects the metabolism of bone tissue, which decreased due to the insufficiency of female sex hormones (estrogens and progesterone), whose level decreases during the postmenopausal period (age-related involution of the sex glands with a significant decrease in their functional activity).

After ingestion, the active substance of Bonviva tablets is absorbed into the blood from the intestinal lumen. Therapeutic concentration in the blood is reached in 20-30 minutes, and the maximum - in 1-, 15 hours after administration. The bioavailability of the drug is worsened while taking tablets with food or drink with a corresponding decrease in the concentration of the active substance in the blood. Ibandronic acid is well distributed in the tissues of the body with a somewhat large accumulation in the bone tissue. The main part of the active substance enters the metabolism of bone tissue and is embedded in the mineral matrix. The rest is excreted in the urine unchanged. There is no reliable data on the passage of ibandronic acid through the blood-brain, placental barrier and getting into breast milk during lactation.

Indications for use

The main indication for the use of Bonviva tablets is osteoporosis (increased fragility) of the bone due to post-menopausal bone resorption in women. The use of the drug is primarily indicated for the prevention of bone fractures in the future, especially for a neck fracture of the femur.

Contraindications

The use of tablets Bonviva contraindicated in several physiological and pathological conditions of the body, which include:

  • Individual intolerance or hypersensitivity to ibandronic acid or auxiliary substances of the drug.
  • Uncontrolled hypocalcemia - a decrease in the level of calcium ions in the blood below the normal value.

Before taking Bonviv tablets, you must make sure that there are no contraindications.


Dosage and administration

Bonviva tablets are taken orally, preferably on an empty stomach or not earlier than 60 minutes after the last meal, as it significantly reduces the bioavailability of the drug. Also, the drug can be taken one hour before meals. After taking the pill drink a small amount of liquid. It is important to take the pills completely, without chewing, as this will reduce the likelihood of irritation of the mucous membrane of the stomach and intestines. After taking the pill, it is desirable for a short period of time to be in an upright position while standing or sitting. The recommended therapeutic dose of the drug is 1 tablet per month on the same day. The course of treatment is determined by the doctor individually on the basis of a biochemical study of the mineral state of the blood and the degree of bone resorption. In case of missing a scheduled admission, it must be taken as early as possible so that the period until the next scheduled admission is not less than 7 days.

Side effects

Taking Bonviva tablets can lead to the development of side effects and negative reactions from various systems and organs, such as:

  • The digestive system - esophagitis (inflammation of the mucous membrane of the esophagus), gastritis (inflammation of the stomach), the formation of erosion (defect of the mucous membrane) in the stomach or duodenum. It may also develop nausea, vomiting, pain in the abdomen, often spastic nature.
  • Musculoskeletal system - a feeling of muscle stiffness and lack of range of motion in the joints, local muscle spasm with the development of severe pain, cramps , arthralgia (pain in the joints).
  • Central nervous system - headache, recurrent dizziness, insomnia.
  • Allergic reactions - mainly characterized by skin manifestations in the form of the appearance of a rash on the skin and its itching, rash develops less frequently (a characteristic rash and swelling, which resemble a nettle burn). Severe allergic reactions in the form of angioedema angioedema (pronounced swelling of the skin and subcutaneous tissue in the face and genital organs) and anaphylactic shock (multiple organ failure with a progressive reduction in systemic blood pressure) rarely develop.
  • Disruption of the general condition in the form of flu-like syndrome - may develop in the initial stages of the drug, is characterized by general weakness, low-grade fever (up to 37.5 ° C), muscle and joint aches, and decreased appetite and disability.

In the event of side effects, you should consult with your doctor, who will determine the need to reduce the dose of the drug or completely stop taking it.

special instructions

Before you start taking Bonviv tablets, you must carefully study the instructions. There are a number of special instructions that you need to pay attention to, these include:

  • Before using the drug, a laboratory study of the exchange of minerals in the body is carried out, first of all, the level of calcium ions is determined. In case of hypocalcemia (decrease in the level of calcium ions), its correction is carried out.
  • Women of fragile physique, in the case of bad habits (smoking), people of the southern European race are recommended to take the drug.
  • Together with Bonviv tablets, it is advisable to take vitamin D and calcium salts for better bone mineralization.
  • There is no reliable data on the dangers of the active ingredient of the drug on the developing fetus, so taking Bonviva tablets during pregnancy and lactation is not recommended.
  • Sometimes taking initial doses of Bonviva tablets may be accompanied by dysphagia (a violation of swallowing).
  • With extreme caution and under clinical and laboratory control, the drug is used in diseases of the kidneys, which are accompanied by a violation of their functional activity and in oncological pathology of bone tissue (there are cases of focal necrosis of bone tissue in the lower jaw area).
  • The drug is not recommended for use in children under 18 years of age.
  • The active ingredient of the drug enters into chemical interaction with ions of mineral salts, therefore, when using other drugs, the interval between their intake must be at least 1 hour (the same applies to food, which may contain a significant amount of various ions of mineral salts) .
  • After taking the pills inside they are not recommended to drink mineral water.
  • With regard to the effect of Bonviv tablets on the concentration of attention and the speed of psychomotor reactions, clinical studies were not conducted.

Overdose

In the case of a significant excess of the recommended therapeutic dose of Bonviva tablets, in most cases symptoms of side effects from the gastrointestinal tract develop. In this case, you must stop taking the drug and seek medical help. For detoxification, washing the stomach and intestines with mineral water is used. Then, intestinal sorbents are taken orally to bind the drug (due to the large amount of calcium ions in the milk, the active ingredient of this drug binds well after it is taken).

Bonviva analogues

The same active ingredient in its composition contain drugs Bondronat, Ibandronic acid.

Terms and conditions of storage

The shelf life of the drug from the time of manufacture is 2 years. It is necessary to store in a place inaccessible for children at air temperature not higher than + 25 ° C.

Bonviva price

The price range for Bonviva tablets in pharmacies is 1600-2000 rubles. for 1 pc. 150mg

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