Bloktran instructions for use
- Bloktran instructions for use
- Form of preparation, its composition and packaging
- Mechanism of action
- When to take
- When and to whom can not be taken
- How to apply and in what doses
- Drug Interactions
- During pregnancy and breastfeeding
- Possible side effects
- How and how much to store
- special instructions
- How to let go of a pharmacy
- Blocktrans analogues
- Bloktran price
The drug Bloktran is an antagonist of angiotensin II type receptors.
Form of preparation, its composition and packaging
The drug is available in the form of tablets covered with a light pinkish-orange shell. Tablets are biconvex.
The active ingredient is potassium losartan. 1 tablet contains 50 mg of potassium losartan, as well as additional substances: starch, MCC, lactose, low molecular weight polyvinylpyrolidone, magnesium stearate, colloidal silicium oxide.
The shell contains: hypromellose, talc, copovidone, tween-80, titanium dioxide, dye-sikovit yellow-orange 85 (E110).
Bloktran is produced in contour cell packs of 10 pcs. They are enclosed in cardboard packs in the amount of 10,20,30,50,60.
Mechanism of action
The drug has antihypertensive effect due to participation in the mechanism of the angiotensin-aldosterone system. Losartan potassium is a specific antagonist of angiotensin II receptors (subtype AT1). Reduces the overall peripheral resistance of blood vessels, as well as the concentration in the blood of angiotensin and aldosterone. Postnagruzka on the heart muscle, which does not give the chance to develop hypertrophy of the myocardium, shows a diuretic effect. Losartan does not show an inhibitory effect on kinase II, a bradykinin-destroying enzyme, which significantly reduces the risk of dry cough in patients, compared with the ACEI group.
A single dose of the drug has a marked decrease in systolic and diastolic blood pressure after 6 hours, then within 24 hours the level of blood pressure gradually decreases and is maintained. Constant reception makes it possible to achieve the maximum hypotensive effect in 20-40 days after the start of taking the drug.
The tablet dissolves rapidly and passes the absorption process from the digestive tract. Its bioavailability is more than 30%. The maximum concentration of losartan in the blood is reached within 50-60 minutes after administration. In the process of achieving the goal, the substance enters the metabolism system in the liver and turns into a more active product (metabolite), which directly and causes an antihypertensive effect. The maximum concentration of the metabolite in the blood is reached after 4 hours. The half-life of losartan is 1.5-2 hours, and its active metabolic product is between 6 and 9 hours. Most (60%) of the drug is excreted through the intestine, as well as through the kidneys (35%).
For patients suffering from cirrhosis, a smaller dose should be selected. Since studies have shown that these patients significantly increase the concentration of losartan in the blood plasma.
When to take
- persistent high blood pressure (arterial hypertension)
- insufficiency of the cardiac muscle in chronic form with insufficient effectiveness of the intake of the ACE inhibitor
When and to whom can not be taken
- Low blood pressure;
- Increase in the concentration of potassium ions in the blood serum;
- Pregnancy and breastfeeding;
- children under 18 years of age (no studies have been conducted);
- individual intolerance to the components of the drug.
Carefully select doses for patients with impaired liver and / or kidney function.
How to apply and in what doses
Bloktran tablets are taken orally, that is, inside. Reception is not dependent on eating, preferably in the morning, once a day.
For the treatment of hypertension (arterial hypertension), the average recommended daily dose is 1 tablet (50 mg). In special cases, it is permitted to increase the dosage in half and take 2 tablets (100 mg) in 1 dose or divide into 2 divided doses (1 tablet in the morning and in the evening).
With heart failure, the starting dose is ¼ tablet (12.5 mg). In the future, depending on the tolerability of the drug, the dose is increased to 1 tablet (50 mg). Dosing should be done gradually at intervals of 6-7 days for every ¼ tablets, that is, ¼, ½, ¾, 1 tablet.
For patients taking concomitant diuretics in large doses, it is necessary to adjust the dose to 25 mg per day.
Reducing the amount of drug intake is also necessary for patients with cirrhous liver disease, the required amount of the drug at the appointment is set by the doctor.
Patients of adulthood do not require dose changes, as well as those who suffer from impaired renal function.
Admission of the drug by children is not provided, since the safety and efficacy of Boktran in this category of patients has not been studied.
Symptoms of a significant excess of the dose of reception of Bloktrans are: a violation of the heart rhythm - tachycardia or bradycardia and a marked decrease in blood pressure below the norm.
Assistance with overdose: diuresis forced, symptomatic therapy, eliminating arrhythmia and hypotension. Conducting hemodialysis is not recommended in view of its inefficiency.
Bloktran can be taken together with other drugs from hypertension. In this case, it is necessary to monitor blood pressure, as it is proved that losartan is able to potentiate the hypotensive effect of drugs from groups of beta adrenoblockers, diuretics, sympatholytic drugs, etc.
There is no interaction with digoxic, ceftethidine, phenobarbital, indirect coagulants, hydrochlorothiazide.
With dehydration, caused by previous treatment with diuretics in high doses, taking Blocktran can cause a pronounced sharp decrease in blood pressure.
Potassium preparations and potassium-sparing diuretics when taken with Blocktrans lead to the development of hyperkalemia (an increase in the concentration of potassium ions in the blood serum).
During pregnancy and breastfeeding
It is strictly prohibited to take Bloktran during pregnancy, as it is proved that drugs whose mechanism of action is based on the regulation of the renin-angiotensin-aldostenone system lead to defects in fetal development or even death. Reception of Blektran at confirmation of the fact of pregnancy should be stopped immediately.
In case of prescription of the drug during the period of breastfeeding, it is necessary to immediately stop the feeding or refuse to receive Bloktran.
Possible side effects
From the nervous system: sleep disturbance, dizziness, memory impairment, headache, depression, migraine, ataxia, asthenia, fatigue.
On the part of the senses : sometimes ringing in the ears, changing taste perception, impaired vision, inflammation of the conjunctiva.
On the part of the respiratory organs : rhinitis, bronchitis , rarely cough, disturbance of the respiratory rhythm.
On the part of the digestive system : dyspepsia, anorexia, bloating, gastritis , stool (constipation), dry mouth
On the part of the musculoskeletal system : pain and cramps in the muscles of the legs, back, arthritis.
From the heart and blood vessels : a sharp decrease in blood pressure, associated with changes in body position, arrhythmia with slowing or accelerating the frequency of contractions, angina .
On the part of the urinary and reproductive system : false urge to urinate, inflammatory processes in the urinary tract, weakening of sexual desire, impotence.
From the skin : increased sensitivity to sunlight and light, sweating, drying out of the skin, alopecia.
Allergic status : rashes, itching, swelling in the face.
Reception Boktran in most cases is well tolerated, and rarely occurring adverse reactions are temporary in nature and do not require immediate cessation of use of the drug.
How and how much to store
Store in a dry place, at a temperature of no higher than 30 ° C. Keep away from children. Apply no more than 2 years from the date of release.
When carrying out dehydration, you must carefully start taking Blocktran from a lower dose.
In patients with stenosis of the renal arteries, the drug causes an increase in the concentration of urea and creatinine in the serum.
Taking Bloktran requires regular monitoring of the potassium concentration in the blood, especially with kidney disorders and in elderly patients.
With renal impairment, the dose of the drug is not reduced, but the patient's condition should be controlled by specialists. When liver disorders should be reduced dosage, as well as monitor the condition of organs and systems.
For the elderly, there is no need to adjust the dose.
Children under 18 years are not applied.
How to let go of a pharmacy
The drug belongs to the list of prescription drugs. Contact the pharmacy with a prescription from your doctor.
Analogues for the active substance (Lozartan): Vazotens, Cosaar, Lozap, Lozarel, Lozartan, Lorista, Prezartan
Bloktran tablets 50 mg - from 150 to 195 rubles.