Binelol instructions for use
- Binelol instructions for use
- Form of formulation and composition of the preparation
- Pharmacological properties of the drug
- Indications for use
- Contraindications for use
- Dosing and Administration
- Application of the drug during pregnancy and lactation
- Adverse Events
- In rare cases, the patient may develop bronchospasm.
- Interaction with other drugs
- special instructions
- Storage and dispensing conditions
- Binafin analogues
- Binafine price
The drug Binelol belongs to the group of beta-blockers, the therapeutic effect of which is to eliminate violations from the cardiovascular system, blood pressure indicators, prevention of strokes in patients at risk.
Form of formulation and composition of the preparation
The drug Binelol is available in the form of white tablets, with a notch in the form of a cross on one side. Each tablet contains 5 mg of active ingredient - nebivolol gibrochloride and auxiliary components.
Pharmacological properties of the drug
When ingested, the main active substance of the drug is quickly absorbed through the mucous membranes of the gastrointestinal tract and penetrates into the common bloodstream. The drug has a pronounced hypotensive property, eliminates the phenomenon of cardiac arrhythmia, normalizes the activity of the cardiovascular system. Patients noted that with the regular use of tablets of the drug, they disappeared from the phenomenon of hypertension, not only in a state of complete rest, but also under physical exertion.
The main active substance of the drug has a mild vasodilating property that favorably affects the work of the central nervous system and the brain in particular. Regular use of this drug eliminates attacks of angina and prevents the development of ischemic stroke or myocardial infarction. In these cases, patients better tolerate physical activity and any disturbances.
Indications for use
Tablets Binelol appoint a patient with a curative and prophylactic goal under such conditions:
- Severe arterial hypertension;
- As part of complex therapy for diagnosed heart failure;
- Cardiac ischemia;
- As part of complex therapy for atherosclerosis of the cerebral arteries;
- Prevention of angina attacks and myocardial infarction in patients at risk (people with excess body weight, smokers, patients with infarct cases, ischemic stroke).
Contraindications for use
Binelol tablets are contraindicated for patients in the presence of such conditions and pathologies:
- Disturbances in the liver and kidneys in the stage of decompensation;
- Myocardial infarction accompanied by cardiogenic shock;
- Acute congestive heart failure, as well as chronic failure in the stage of decompensation;
- Bronchial asthma or bronchial obstruction;
- Prolonged depression with suicidal tendencies;
- An untreated pheochromocytoma;
- Change the pH of the blood in the acidic side;
- Low blood pressure;
- Myasthenia gravis;
- Individual intolerance to the components of the drug;
- Raynaud's disease;
- Age to 18 years;
- Lactase insufficiency or complete lactose intolerance.
This drug should be used with caution in patients with diabetes mellitus and other diseases of the endocrine system, psoriasis, systemic blood diseases, weighed allergic anamnesis, chronic obstructive pulmonary disease, and elderly patients.
Dosing and Administration
The drug Binelol is intended for oral administration. The tablet should be taken strictly at the same time, and 1 time per day, regardless of meals. The drug is not chewed and washed down with a sufficient amount of water.
The daily dose of the drug is determined by the doctor, depending on the diagnosis, the severity of the clinical symptoms of the disease, the presence of concomitant pathologies and individual characteristics of the patient's body. The initial therapeutic dose of Binelol is 2.5 mg per day, for patients with impaired liver function this dosage is no longer increased. In the absence of therapeutic effect or the presence of concomitant severe diseases, the daily dose of the drug to patients who have no abnormalities in the liver can be increased to 10 mg. The length of the course of therapy is determined by the doctor.
Application of the drug during pregnancy and lactation
In the first trimester of pregnancy, this drug is not assigned to women because of a lack of reliable data on its safety for fetal development.
In the second and third trimesters of pregnancy, drug treatment is possible only if there are serious indications and if the potential benefit to the mother is higher than the likely harm to the fetus.
Treatment with the drug shortly before birth increases the risk of bradycardia and respiratory tract paralysis in a newborn baby, so about one week before the expected date of delivery, Binelol should be discontinued.
Animal studies have shown that the active ingredients of the drug easily penetrate into breast milk and are passed on to the baby, so if a woman needs to undergo treatment with Binelol then breastfeeding will have to be stopped.
The drug as a whole is well tolerated, but with a patient's increased dose or uncontrolled long-term use, side effects quickly develop:
- From the nervous system: dizziness and headaches, increasing weakness, drowsiness, in rare cases, depression, decreased concentration, convulsions , paresthesia;
- On the part of the organs of the digestive canal: abdominal pain, constipation, increased gas formation, nausea, dry mouth;
- From the heart and blood vessels: the development of acute heart failure, bradycardia, shortness of breath, impaired heart rate, a sharp decrease in blood pressure, pain in the heart;
- Allergic skin reactions - erythema, skin itching;
In rare cases, the patient may develop bronchospasm.
When an overdose of the drug, the above phenomena are acute. To the listed symptoms adds cyanosis of the extremities, cardiac arrhythmias, cardiogenic shock, loss of consciousness, coma.
With the development of such symptoms of drug overdose, the patient needs to lie down with an elevated leg end, give an activated carbon or other enterosorbent to drink, call an ambulance.
Treatment of an overdose with beta-blockers is in gastric lavage and symptomatic therapy. With the development of bronchospasm, the patient is given beta2-adrenomimetics intravenously, with pronounced bradycardia, intravenous atropine is indicated. With the development of AV-blockade (II and III degree), intravenous beta-adrenostimulators are injected. With the development of heart failure, the patient is administered cardiac glycosides and diuretics. With convulsions - intravenously diazepam.
Interaction with other drugs
With the simultaneous use of Binelol with nitroglycerin or antihypertensive drugs, the patient rapidly develops a sharp decrease in blood pressure, which can lead to collapse.
With the simultaneous use of this drug with general anesthesia, the patient significantly increases the risk of developing arterial hypotension.
With the simultaneous use of Binelol with antidepressants or barbiturates, the hypotensive effect of beta-blockers is intensified, which should be taken into account when prescribing these tablets.
This drug, like any other agent from the group of beta-blockers, can not be abruptly abolished, as this can lead to the development of heart failure or myocardial infarction.
At the beginning of the course of therapy, the patient needs to monitor blood pressure and heart rate daily. In elderly patients, once every 4 months, the condition of the urinary system and their function should be checked.
With the development of bradycardia drug can not be canceled, but simply reduce the daily dose.
If surgical intervention is necessary, the patient should notify the surgeon that he is undergoing beta-blocker therapy.
The drug should be given with special care to patients with diabetes mellitus, since the active substance of Binelol can affect the level of glucose in the blood.
In people with allergies, taking this medication may increase the risk of allergic reactions and bronchospasm.
If the patient is an active smoker and takes Binelol tablets, then he may experience a decrease in the therapeutic effect of the drug.
Storage and dispensing conditions
The drug is dispensed in pharmacies on prescription. Duration of storage of tablets is 2 years from the date of manufacture. The drug should be stored out of reach of children, avoiding direct sunlight at a temperature of no higher than 25 degrees.
Analogues for the active substance (Nebivolol): Nebivator, Nebivolol, Nebilet, Nebelong, Nevotenz
Prices for tablets Binafin are very different in different pharmacies in Moscow. The price range is from 300 to 504 rubles