The Bifosin: instructions for use, price, testimonials, spray analogues from nail fungus on legs Bifosin
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Bifosin spray instruction manual

Bifosin spray instruction manual

Means for external use with antifungal activity.

Form of preparation, its composition and packaging

A spray containing 1% bifonazole is used externally, has the form of a clear liquid without color or with slight staining.

In 1 ml of the spray enters biphonazole in an amount of 10 mg, and additional substances: propylene glycol - 0.3 ml, isopropanol - 0.4 ml, macrogol 400 (PEO 400) - up to 1 ml.

It is produced in polymer bottles with a sprayer, with a capacity of 20 ml, which are packed in cardboard packs of 1 piece each.

Indications for use

The drug Bifosin is used as a therapeutic agent in fungal skin lesions such pathogens as: dermatophytes, yeast-like and mold fungi, as well as Malassezia furfur and Corynebacterium minutissimum.

Used for mycotic lesions of feet and smooth skin, deprived of otriparous, erytaz, candidiasis on the surface of the skin, as well as in case of infection with fungal pathogens of the scalp.


- individual hypersensitivity to the constituents of the drug

-period of breastfeeding

Under the close supervision of a doctor before the age of 12 months and in the first trimester of bearing a child.

Mechanism of action

The drug has a sufficient range of antifungal action, it is used to apply directly to the infection site. Bifonazole by chemical structure belongs to the group of imidazole derivatives. It shows a fungicidal effect on the group of dermatophytes (Trichophyton, Microsporum, Epidermophyton), stops growth and reproduction of yeast-like and mold fungi (Aspergillus ferrus, Scopulariopsis brevicaulis), Malassezia furfur. In addition, it has a deleterious effect on some bacteria - on the Gram-positive rod Corynebacterium minutissimum (MIC ranging from 0.5 to 2 μg / ml) and on Gram-positive cocci (MIC 4-16 μg / ml), does not affect the viability of Enterococcus spp.

Bifonazole inhibits the synthesis of ergosterol - one of the main substances that make up the shell of the fungal organism. Influence occurs at two stages of accumulation of the given substance, therefore the complete damage of the fungal membrane with disturbance and the structure and function is observed. This leads to its death (fungicidal action) or to the cessation of reproduction and growth (fungistatic action).


The drug quickly penetrates deep into the skin in the foci of the disease. Absorption is 0.6-0.8%, while in the blood bifonazole is not detected.

Only 6 hours after the application of the drug at the site of application, the concentration necessary for therapy is observed. It is 1 mg / cm 2 in the uppermost layer of the skin - the epidermis and 5 mg / cm 2 in the lower layers. This concentration guarantees fungicidal action for the most common pathogens that can cause dermatomycosis.

The drug continues its action in the skin for 36-48 hours. The half-life is 19-32 hours and depends directly on the density of the skin in the lesion.

How to apply and in what doses?

Bifosin spray is applied to the surface of the skin, which was affected by dermatomycosis once a day, preferably overnight. When applying, spray the spray in an amount that can moisturize the skin well. In addition to affected areas, the intact skin should be treated, that is, the skin around 1-2 cm from the edges of the focus.

The course of treatment depends on the type of dermatomycosis and its localization. The main principle ensuring proper effectiveness is the continuity of treatment and the maintenance of the full course. With a fungal infection of the feet and interdigital zones, the drug should be used for 21-28 days, with infection of smooth skin -14-21 days, diseases caused by Candida albicans - 14-28 days, lichen pendulous and erythematism must be treated for at least 14 days, scalp injury requires treatment for about 28-30 days. Recent diseases, in view of the specificity of the surface, require the preferred use of Bifosin spray, which is easy to apply and does not lead to sticking and contamination of the hair.

In order to prevent the possibility of recurrence of the disease should continue the course of therapy and after the elimination of clinical manifestations of the disease for another 14 days, maintaining the dosage - 1 time per day.


In view of the low adsorption of the drug into the total bloodstream, it is almost impossible to overdose Bifosin.

Possible interaction with other drugs

Joint use of Bifosin with other drugs has not revealed any reactions, so this spray can be used in parallel with other medications.

Pregnancy and lactation

During the clinical trials it became apparent that Bifosin Spray does not show any harmful or any negative impact on the fetus and the organism of the expectant mother.

Use Bifosin in the first trimester of pregnancy should be carried out only according to strict indications. In the second and third trimesters Bifosin can be used to treat fungal infection.

It is necessary to stop breastfeeding the child in case of using Bifosin in this period.

Possible side effects

Of the possible side effects occur: redness of the skin at the site of application, irritation and burning, allergic reaction in the form of rash, itching, eczema, and peeling. Very rarely, the use of the drug can lead to allergic dermatitis.

All side effects can be eliminated by canceling the drug.

How and how much to store

The drug form of the spray requires storage in a dark place, not above 25 ° C. Use within 2 years from the date of release.

Keep away from children.

special instructions

If the effectiveness of treatment is inadequate, a more thorough examination of the patient is required and appropriate correction of therapy is performed.

Cautiously use in infants, only as directed by a physician.

Avoid contact with eyes

Does not affect the management of vehicles and other mechanisms, as well as the performance of works requiring caution and increased attention.

How to let go of a pharmacy

The drug belongs to the group of OTC.

Bifosin analogues

The group of antifungal agents based on bifonazole is presented:

  • Bifasam is a cream of domestic production. Has the same packing, composition and indications as Bifosin. Drug manufacturer: Samaramedprom (Russia) ;
  • Mikospor is an analogue of foreign production. It is available in the form of a cream, ointment in a set for the treatment of nail lesions, and also as a solution for external use. Manufacturer means: Bayer HealthCare AG (Germany) .

Bifosin price

Bifosin Spray for external use 1% 20ml - from 95 rubles.

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