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Bicillin - 3 instructions for use

Bicillin - 3 instructions for use

Bicillin-3 is a combined antimicrobial agent with a narrow spectrum of antibacterial action, which is a representative of the penicillin group. The group is known for its natural origin, as it is produced by some species of mold from the genus Penicillinum. Benzylpenicillin is one of the most persistent representatives of natural penicillins.

Benzylpenicillin is active against:

  • Gram-positive bacteria such as staphylococci, streptococci, enterococci, corynebacteria diphtheria, listeria, clostridia, anaerobic spore-forming bacillus of the genus Bacillus;
  • Gram-negative bacteria: gonococci, meningococci, actinomycetes, spirochetes.

The antibiotic does not have antibacterial activity and is not used to treat diseases caused by:

  • viruses;
  • mycobacteria of tuberculosis;
  • the simplest;
  • rickettsia;
  • mushrooms;
  • other gram-negative microorganisms;
  • strains producing penicillinase.

The mechanism of action is based on the inhibition of a specific enzyme, which takes part in the formation of the basic structural component of the cell wall. As a result, the strength of the cell wall is disrupted, and pathogenic bacteria are destroyed.

Disadvantages of benzylpenicillin are:

  • instability to penicillinases;
  • slight digestion in the stomach;
  • Low effectiveness against many gram-negative pathogens.

In medical practice, soluble salts of benzylpenicillin are used: potassium and sodium salts. However, due to the short duration of their action, long-acting forms are also used in the form of poorly soluble salts. These are benzathine benzylpenicillin and benzylpenicillin novocaine salt.

Bicillin-3 is a combination of 3 salts of benzylpenicillin: benzathine benzylpenicillin, benzylpenicillin sodium and novocaine salt. Due to poor salt dissolution, a depot is created at the injection site, which reduces the frequency of injections, and maintains the concentration of the antibiotic in the blood at the desired level.

The main condition for the appointment of Bicillin is the need to maintain effective concentrations of antibiotic in the blood for a long period. They are prescribed for syphilis and other infections caused by treponema, streptococcal infections such as tonsillitis, scarlet fever , infected wounds, erysipelas, rheumatism, leishmaniasis.

Form of issue and composition

Dosage form Bicillin-3 is a powder for preparing a sterile solution, which is used for intramuscular injection. The powder is white, sometimes a yellowish tinge may be present. The drug is produced in 10 ml vials.

1 bottle containing the contents for the preparation of an intramuscular injection solution contains:

  • benzathine benzylpenicillin, benzylpenicillin sodium and benzylpenicillin novocaine salt to 200 thousand units 400 thousand units.

The medicine refers to the antibiotics of the penicillin series, is produced by natural means, is dispensed solely on the prescription of a doctor.

Indications for use

Indications for use Bicillin-3 is an infection caused by bacteria that are sensitive to penicillin, especially when taking long-term treatment:

  • scarlet fever;
  • erysipelatous lesion;
  • syphilis primary, secondary, unknown genesis;
  • yaws (syphilis tropical);
  • Rheumatism, rheumatoid arthritis, rheumatic carditis, rheumatoid diseases;
  • tonsillitis , lacunar angina , catarrhal angina;
  • wound infection: infected wounds, burns, purulent wounds, wound botulism.


  • hypersensitivity to the active components of the drug or excipients, as well as other penicillins;
  • hypersensitivity to other medicines in the anamnesis.

Persons receiving bronchial asthma should be prescribed with caution.

Mode of application

The drug is administered only intramuscularly. At a dosage of 300 thousand units are administered 1 time in 4 days. At a dosage of 600 thousand units - 1 time in 6 days.

Antibacterial therapy of primary and secondary syphilis consists of 7 intramuscular injections, which are produced according to the following scheme:

  • the first dose - 300 thousand units;
  • the second dose is 1.8 million units;
  • the rest - 1.8 million units 2 times a week.

Antibacterial therapy of recurrent secondary and latent syphilis includes 14 injections of the drug, which are produced according to the following scheme:

  • the first dose - 300 thousand units;
  • the rest - 1.8 million units 2 times a week.

Side effects

  • various anemia, a decrease in the number of platelets or leukocytes in the blood, a decrease in blood clotting;
  • skin rashes, rashes on the mucous membranes, increased amounts of eosinophils in the blood, dermatitis, Quincke's edema , anaphylaxis;
  • headache, joint pain, fever;
  • inflammation of the tongue or mucous membrane of the mouth;
  • With prolonged treatment, it is possible to develop superinfection or fungal attack.

Special instructions and drug interactions

  • the drug can not be administered intravenously;
  • the presence of blood in a syringe with an injection indicates the ingress into the vessel, in connection with which it is necessary to change the injection site;
  • after injection, the injection site should not be ground, simply pressed and held;
  • when allergic symptoms appear, the drug is discontinued;
  • when anaphylaxis develops, urgent measures are taken: inject norepinephrine, glucocorticosteroid drugs, artificially ventilate the lungs;
  • It is necessary to conduct microbiological serological tests before the treatment and for 4 months after it if suspected of syphilis;
  • for the prevention of fungal development, it is recommended to take vitamin C and group B, sometimes showing nystatin or levorin;
  • use of insufficient doses or discontinuation of therapy before the recommended course leads to the formation of resistant strains of microorganisms;
  • antibiotics that have a bactericidal effect, enhance the action of Bicillin-3, and those with a bacteriostatic effect - reduce;
  • when using the drug, the effectiveness of tableted contraceptive drugs is reduced;
  • diuretics, allopurinol, phenylbutazone, NSAIDs decrease the excretion of the antibiotic, as a result of which its concentration in the blood increases.


Preparations similar to Bicillin-3 are represented by various salts of benzylpenicillin of domestic production. Other drugs, based on penicillins, are semisynthetic analogues that are resistant to the action of penicillinase and have a broad spectrum of antibacterial action. These drugs are based on ampicillin, amoxicillin , carbenicillin and others, available in the form of tablets, capsules and parenteral forms.

Terms and conditions of storage

Shelf life of antibiotic is 3 years. The storage location must be dry and out of reach of children, the temperature should not exceed 15 degrees. Application after the expiry date is prohibited.

Bicillin-3 price

Bicillin-3 powder for the preparation of injection solution 1200000ED - from 10 to 18 rubles.

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