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Baralgin tablets instructions for use

Baralgin tablets instructions for use

Baralgin - analgesic and antipyretic, belonging to the group of non-narcotic nonsteroidal agents. It has analgesic, antipyretic and mild anti-inflammatory effect.

Release form and composition

Baralgin released in tablets (10 tablets in a blister), in packs of 10, 20, 50 and 100 tablets.

The main active ingredient is metamizole sodium. 1 tablet baralgin contains 500 mg of metamizol.

Auxiliary components: magnesium stearate, macrogol.

Until 2009, the drug Baralgin was registered in the country, which consisted of 3 active ingredients - metamizole sodium, pitofenone, fenpiverinium bromide. Since 2009, Baralgin M, containing only one active ingredient, metamizole sodium, has been registered and approved for dispensing through the pharmaceutical network.

pharmachologic effect

Pharmacodynamics. Metamizole belongs to the group of non-narcotic analgesics, derivatives of pyrazolone. It is characterized by analgesic, antipyretic and weak anti-inflammatory effects. The mechanism of action due to the inhibition of the synthesis of prostaglandins (they take part in the development of the painful and inflammatory process) is similar to the effect of other non-narcotic analgesics.

Pharmacokinetics. Metamizole is rapidly absorbed in the gastrointestinal tract, is broken down in the liver to the active metabolite. About 50–60% of the active substance is bound to plasma proteins. Excreted mainly by the kidneys. The half-life is 2.7 hours (in patients with cirrhosis of the liver, this figure increases to 10 hours). At therapeutic concentrations, the drug is absorbed into breast milk.

Indications for use

Indications for use Baralgin is:

  • mild and moderate pain of various origins (headache, toothache, pain with arthritis, radiculitis, myalgia, sciatica, neuralgia);
  • pain after diagnostic procedures and surgical interventions (Baralgin appointed as an aid);
  • fever accompanying infectious and inflammatory diseases (Baralgin is recommended as part of complex therapy);
  • smooth muscle spasm (with intestinal, hepatic and renal colic, spasms of the bladder and ureter).

Contraindications

Baralgin contraindicated in the following pathologies:

  • bronchial asthma (including asthma caused by taking aspirin, salicylates and other nonsteroidal anti-inflammatory drugs) and other pathologies accompanied by bronchospasm;
  • congenital deficiency of glucose-6-phosphate dehydrogenase;
  • hepatic porphyria;
  • pronounced functional disorders of hematopoiesis (agranulocytosis, infectious and / or cytoplastic neutropenia);
  • the development of anaphylactic reactions (edema, urticaria, rhinitis) while taking non-steroidal anti-inflammatory drugs;
  • severe functional impairment of the kidneys and liver;
  • individual intolerance to metamizole and other pyrazolones, other components of the drug;
  • under the age of 15 years;
  • in the I and III trimesters of pregnancy.

Dosing and Administration

The recommended dosage of Baralgin for adults is from 0.5 g to 1 g (1-2 tablets), the frequency of application is 2-3 times a day. The maximum daily dosage should be no more than 3 g (6 tablets). The tablets are taken whole, washed down with enough water. The duration of treatment should be no more than 3 days when used as a febrifuge and no more than 5 days when used as an anesthetic.

Side effects

Baralgin is usually well tolerated. In some cases, the development of undesirable side effects is likely:

  • on the part of the cardiovascular system - a sharp decrease in blood pressure (may occur in patients with a sharp increase in body temperature);
  • on the part of the hematopoietic system - agranulocytosis (rarely), leukopenia, thrombocytopenia (noted in patients with pathologies of the immune system);
  • on the part of the excretory system - transient functional disorders of the kidneys (proteinuria, anuria, oliguria, interstitial nephritis), which usually develop with regular long-term administration of Baralgin or in patients with kidney disease in history;
  • allergic reactions - a rash on the skin, mucous membranes of the nasopharynx or conjunctiva, angioedema , bronchospasm, anaphylactic shock (very rare).

With the development of anaphylactic shock, emergency medical care is required - slow intravenous administration of an adrenaline solution (if necessary, repeated after 15 to 30 minutes). Then glucocorticoids and antihistamines are introduced, the blood volume is replaced, and the heart is massaged.

When Baralgin is taken, agranulocytosis can develop, which is manifested by a deterioration in the patient’s general condition, fever, inflammation of the oral mucosa and nasopharynx, and increased ESR.

Symptoms of thrombocytopenia are point hemorrhages on the skin and / or mucous membranes, increased tendency to bleeding. If signs of thrombocytopenia or agranulocytosis occur, Baralgin should be discontinued.

An overdose of the drug causes nausea and vomiting, hyperthermia, convulsions , stomach pain, decreased blood pressure and tinnitus, drowsiness, shortness of breath, tachycardia , impaired consciousness, paralysis of the respiratory muscles.

When these symptoms appear, gastric lavage, the appointment of saline laxatives and sorbents, and forced diuresis and hemodialysis are required. With the development of convulsive syndrome, diazepam and high-speed barbiturates are injected intravenously.

special instructions

When applying Baralgin important to know:

  • high risk of intolerance to the drug in patients with chronic urticaria, intolerance to alcohol, dyes and preservatives (benzoate, tartrazina);
  • the use of baralgin can cause urine staining in red color, which has no clinical significance and passes immediately after discontinuation of the drug;
  • With long-term treatment with Baralgin, control of the composition of peripheral blood is required;
  • You can not use the drug for the relief of acute abdominal pain before finding out the causes of pain;
  • Baralgin should not be taken in high doses in patients with impaired liver and kidney function.

With care, Baralgin is prescribed to patients with:

  • blood pressure below 100 mm Hg. v .;
  • unstable blood circulation (with shock, myocardial infarction, multiple injuries);
  • renal pathologies (glomerulonephritis, pyelonephritis);
  • impaired peripheral blood (including after treatment with cytostatics).

Drug Interactions:

  • Baralgin cannot be combined with radiopaque substances, penicillins, colloidal plasma-substituting solutions (an intolerance reaction may occur);
  • simultaneous administration of baralgin and cyclosporine leads to a decrease in the concentration of the latter in the blood plasma;
  • taking the drug with other non-narcotic analgesics enhances the toxic effect of both drugs;
  • phenylbutazone and barbiturates weaken the therapeutic effect of baralgin;
  • Baralgin's analgesic effect is enhanced while taking it with sedatives and tranquilizers, codeine, propranolol, H-2 blockers;
  • combined use with phenothiazine derivatives leads to the development of severe hyperthermia;
  • when taken concomitantly with oral contraceptives, allopurinol and tricyclic antidepressants, Baralgin’s metabolism is disturbed in the liver and its toxic effect is enhanced;
  • when drinking alcohol while taking Baralgin, the toxic effect of alcohol and the drug is enhanced.

Use during pregnancy and breastfeeding

The drug can be administered to pregnant women in the second trimester (from 4 to 6 months) only under strict indications. When used during lactation, breast feeding should be stopped for 48 hours after taking Baralgin.


Analogs Baralgin

Structural analogue of Baralgin, containing the same active ingredient, is the drug Analgin.

By a similar mechanism of action, but having a different composition, drugs include: Antipyrin, Baralgetas, Quintalgin, Maksigan, Spazmalin, Tetralin, Bralangin, Revalgin.

Terms and conditions of storage

The drug is stored in a dry, protected from sunlight and out of reach of children at room temperature (from 8 ° C to 25 ° C). Shelf life is 4 years. Tablets should not be taken after the expiration date indicated on the package.

Baralgin price

Baralgin M tablets 500 mg, 20 pcs. - from 183 rubles.

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