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Baralgin M injections: instructions for use

Baralgin M injections

Baralgin M solution has antipyretic and analgesic effects on the body. Refers to the group of pyrazolones. It can be used for the elimination of pronounced pain that is not eliminated by other drugs, as well as during feverish conditions caused by various causes. Baralgin M is considered a non-narcotic analgesic. Its half-life reaches about 14 - 15 minutes. It inhibits prostaglandin synthesis. It has a slightly pronounced anti-inflammatory effect on the body.

Release form and composition

Baralgin M is a solution for injections. The active ingredient is sodium metamizol. 1 ml of Baralgin M contains 500 mg of metamizole sodium. The vial has a volume of 5 ml. Additional substance - water for injections. The secondary cardboard box contains a tray with ampoules in the amount of 5 pieces and detailed instructions. On the package you can find information about the manufacturer, the term of validity and the series of production.

Indications for use

Baralgin M is quite widely used in medical practice. His appointment is justified in the treatment of pain of various strengths, which are difficult to eliminate with the help of other drugs. It can be used in febrile conditions that are difficult to stop for various reasons.

Contraindications

The ban on taking the drug Baralgin M is available in the following conditions:

  • asthma, bronchial or other diseases that can provoke bronchospasm;
  • known hypersensitivity to pyrazolones or metamizole sodium;
  • sensitivity reactions to pyrazolidine. The occurrence of agranulocytosis in the use of drugs in this group;
  • last and first trimesters in women carrying a child;
  • the risk of hemolysis exists with congenital deficiencies of glucose-6-phosphate dehydrogenase;
  • serious allergic manifestations caused by taking such analgesics as naproxen, paracetamol, indomethacin and others, as well as salicylates. Such manifestations may include cases of anaphylactic reactions, edema, rhinitis, urticaria;
  • children up to 3 months of age with a weight not exceeding 5 kg;
  • malfunctions in the bone marrow. These conditions can occur after cytostatic therapy or in the treatment of diseases of the hematopoietic system;
  • the possibility of developing attacks of porphyria appears when Baralgin M is used in patients with acute intermittent hepatic porphyria;
  • during lactation;
  • Baralgin M solution can not be used in patients with low blood pressure or any hemodynamic disorders;
  • impaired renal or hepatic function.

Dosing and Administration

Rules for taking Baralgin M for adolescents from the age of 15 years and adults: a single dose ranges from 500 mg to 1 gram. The daily dosage should not exceed 2 grams. It should be divided into 3 doses. It is allowed to use solution both for intravenous, and for intramuscular use.

In children from 3 months and up to a year, with body mass indicators of 5 to 9 kg, the administration of Baralgin M is carried out strictly intramuscularly. The recommended dosage is from 50 to 100 mg per 10 kilograms of weight (approximately 0 .1 - 0 .2 ml of 50% solution). This single dose can be used no more than 3 times over 24 hours.

It is important before the introduction of Baralgin M to heat the solution to body temperature. Too rapid introduction can provoke a state of shock. For intravenous administration, the rate should be no more than 1 ml per 1 minute strictly in the supine position of the patient. At the same time, respiration, pulse and blood pressure are monitored. Special care is needed when administering the drug Baralgin M in a dose exceeding 2 ml. Perhaps a sharp drop in blood pressure.

The duration of therapy is prescribed by the attending doctor individually.


Side effects

The following adverse events were observed during treatment with Baralgin M:

  • phlebitis, soreness at the injection site;
  • burning sensation accompanied by itchy manifestations;
  • leukopenia. Thrombocytopenia or agranulocytosis may be rare;
  • angioedema ;
  • rash ( urticaria );
  • malfunction of the kidneys. Usually they are expressed in the form of anuria, urine staining in a reddish tint, proteinuria, oliguria. Sometimes there is acute interstitial nephritis;
  • bronchospasm;
  • anaphylactoid manifestations;
  • the occurrence of arrhythmias;
  • a sharp drop in blood pressure indicators;
  • A rare complication is Lyell syndrome and Stevens-Johnson syndrome.

special instructions

With simultaneous intake of cytotoxic drugs, Baralgin M treatment is carried out only under observation. If a long course is required, periodic monitoring of the blood picture is necessary. If agranulocytosis was triggered by the use of Metamizole, it lasts at least 7 days and is capable of life-threatening. The relationship between the occurrence of this condition and the dosage used was not found.

Abolishing the use of Baralgin M is necessary with a sudden rise in temperature, accompanied by chills, pain in the oral cavity, the appearance of erosive lesions on the mucous membranes of the oral cavity. Severe neutropenia also requires discontinuation of the drug.

Reported cases of anaphylaxis usually occurred in patients prone to allergic manifestations and with a history of bronchial asthma. At risk are people with urticaria, rhinosinusitis, or those with alcohol intolerance or intolerance to a variety of dyes.

Intravenous injections are performed slowly to reduce the likelihood of complications. With caution applied Baralgin M in the presence of low pressure or high temperature. Special attention is paid to people with heart failure, glomerulonephritis and other kidney diseases.

It is unacceptable to use Baralgin M in cases of severe pain in the abdominal region without an established diagnosis.

For intramuscular injection, long needles are used.

In pediatrics, intravenous injections are prohibited for use in patients up to 1 year.

Pregnancy: there is a possibility of closing the arterial duct prematurely. Baralgin M is not used in the last and first trimesters. In another period, it is allowed to take the drug only under control and according to strict indications.

When lactating after injection Baralgin M can not breastfeed for 2 days.

Driving vehicles for drug treatment is possible, but caution is required when prescribing higher doses of Baralgin M.

Overdose requires treatment in the form of symptomatic therapy. There is no antidote at the moment. Perhaps the implementation of hemodialysis and forced diuresis. If convulsions develop, diazepam should be given intravenously.

Drug interactions

The drug enhances the sedative effect of alcoholic beverages. Acceptance of other non-narcotic analgesics with baralgin M leads to increased toxic manifestations. When taken with cyclosporin, control of its concentration in plasma is required.

The increase in the toxicity of Baralgin M and the change in its metabolism occur during interactions with oral contraceptives, allopurinol and tricyclic antidepressants.

The weakening of the effect of sodium metamizol is observed when it is used with phenylbutazone or barbiturates.

The increased analgesic effect is noticeable when Baralgin M is combined with tranquilizers and sedative components.

Hyperthermia is more likely to occur when taking Metamizole sodium in combination with phenothiazine derivatives.

During therapy with Baralgin M, radiopaque substances, penicillin drugs and colloid blood substitutes cannot be used simultaneously.

Metamizole sodium enhances the activity of indomethacin, indirect anticoagulants and glucocorticosteroid substances.

The likelihood of leukopenia is increased by sarcolysin and tiamazol.

In one syringe, Baralgin M is not allowed to be mixed with other medicinal substances.


Analogs of injections Baralgin M

After consulting with a doctor, Baralgin M can be replaced with a dipyne solution with the required dosage, which is produced by many pharmaceutical companies.

Terms and conditions of storage

Baralgin M can be stored for 5 years. After the end of the term shelf life injections are prohibited. Storage should be in a dark place. The recommended temperature range is from 8 to 25 degrees Celsius. Keep ampoules away from children in factory cartons. From the pharmacy institutions, the release of the Baralgin M medication occurs according to a medical prescription.

Baralgin ampoules Price

Baralgin M injection 500 mg / ml, 5 ampoules - from 230 rubles.

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