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Baklosan instructions for use

Baklosan instructions for use

Baklosan is a pharmacological agent of the group of muscle relaxants. It reduces the tone and tension of striated muscles. It is used to reduce the severity of muscle spasm, tension and for muscle relaxation in various diseases of the structures of the central nervous system.

Release form and composition

The drug Baklosan is made in the form of round, biconvex tablets of white color. The active ingredient of the drug is baclofen, which is contained in a concentration of 10 mg and 25 mg in one tablet. It also includes the following excipients:

  • Potato starch.
  • Lactose.
  • Gelatin.
  • Magnesium stearate.
  • Talc.
  • Ethyl cellulose

The tablets are packaged in plastic bottles in an amount of 50 pieces. One carton pack contains one plastic bottle. Such packing provides a long course of use of tablets Baklosan.

pharmachologic effect

The active ingredient of the tablets Baklosan baclofen is a derivative of gamma-aminobutyric acid. It belongs to the pharmacological group of drugs - centrally acting muscle relaxants. Baclofen has antispastic (relieves muscle spasm) and muscle relaxant (relaxes striated muscle) action due to these pharmacological effects:

  • Reduces the excitability of the sensitive (afferent) nerve fibers of the spinal cord and brain, thereby reducing the excitability and readiness of the nervous system to the development of muscle cramps.
  • Suppresses the functional activity of intermediate neurons that are responsible for the transmission of impulses to the motor (afferent) nerve fibers.
  • Reduces the prestress of striated muscle fibers.

Due to these pharmacological effects of the active substance, the Baklosan tablets reduce the convulsive readiness of the muscles, reduce the severity of contractile tension in them, increase the range of motion in the joints due to relaxation of the muscle fibers (muscle relaxation). The drug does not affect the neuromuscular transmission of the impulse in the corresponding synapses directly.

After taking the pill inside, the active substance is absorbed into the blood and reaches its therapeutic concentration in 20-30 minutes. The maximum concentration in the blood is reached in 2-3 hours. The bioavailability of baclofen is quite high. It penetrates well through the blood-brain barrier and accumulates in the tissues of the central nervous system. Also, the active ingredient of the tablets Baklosan penetrates well through the placental barrier and can accumulate in the body of a developing fetus during pregnancy. Baclofen is excreted in breast milk during lactation. Metabolism occurs in the liver, metabolites (metabolic products) and the unchanged active substance are excreted by the kidneys in the urine.

Indications for use

Baklosan tablets are used in the treatment of pathological conditions, which are accompanied by an increased tone of different groups of striated muscles. These diseases include:

  • Multiple sclerosis is a degenerative chronic disease of the structures and nerve fibers of the central nervous system, accompanied by the development of foci of increased nervous excitability.
  • Malignant or benign tumors of the spinal cord or brain, which in varying degrees affect the motor centers and intermediate neurons.
  • Infectious pathology of the spinal cord or brain.
  • Syringomyelia, which is accompanied by a violation of the synthesis of the membranes of nerve fibers with a change in the processes of impulses in them.
  • Brain stroke affecting motor centers.
  • Transferred injuries of the organs of the central nervous system - closed or open head injury, injuries of the spine and spinal cord.
  • Cerebral palsy (CP) is a consequence of acute hypoxia (lack of oxygen) of the brain during the perinatal period with the development of pronounced spasm of striated muscle.
  • Meningitis is an inflammatory process in the membranes of the spinal cord or brain that affects the functional activity of the structures of the central nervous system.
  • Chronic alcoholism, which develops alcohol toxic damage to various structures of the brain and spinal cord.

The indications for the use of Buklosan tablets are established individually after an appropriate neurological examination.

Contraindications

Acceptance of tablets Baklosan is contraindicated in the presence of such pathological or physiological conditions of the body:

  • Hypersensitivity or individual intolerance to the active ingredient or auxiliary component of the drug.
  • Epilepsy is a severe pathology of the central nervous system, which is characterized by the development of seizures of pronounced tonic-clonic seizures.
  • Having convulsive seizures in the past.
  • Psychosis is an acute violation of the functional activity of the cerebral cortex, accompanied by the development of hallucinations, motor and speech arousal, and the appearance of delusional thoughts.
  • Parkinson's disease is a marked impairment in the transmission of nerve impulses between motor structures and the centers of the brain and spinal cord.
  • Acute or chronic renal failure, in which the excretion of metabolites and unchanged active substance from the body is sharply reduced.
  • Pregnancy at any time and breastfeeding (if necessary, use of the drug during breastfeeding, the child is transferred to the reception of artificial adapted milk formulas, for the period of use of tablets Baklosan).

With caution, Baklosan tablets are used for cerebrovascular insufficiency (a decrease in the volume and intensity of blood circulation in the brain), for gastric ulcer or duodenal ulcer, in old age and in children under 12 years of age.


Dosage and method of use

Baklosan tablets are taken orally, entirely after a meal, washed down with a sufficient amount of liquid. The doctor sets the dosage and duration of the course of treatment individually. The average therapeutic dose of the drug depends on the age, they are:

  • Children aged 1-2 years - 10-20 mg per day.
  • Children aged 2 to 6 years - 20-30 mg per day in divided doses.
  • Children aged 6-10 years - 30-60 mg per day.
  • Children over 10 years of age - the dose is calculated on the basis of a recommendation of 2 mg of active ingredient per 1 kg of body weight of a child per day.
  • Adults - the initial vine is 5 mg 3 times a day. Then within a few days it is increased to achieve a therapeutic effect (usually up to 30-75 mg per day). The maximum daily dose is 100 mg per day.
  • People over 65 years old - the dosages are the same as for adults, but the increase in therapeutic dose is carried out gradually, over a longer period of time and under the constant control of laboratory parameters of the functional activity of the liver and kidneys.

The course of the drug is quite long, in each case, his doctor sets individually, depending on the underlying pathology, the age of the patient and his general condition.

Side effects

Taking the pills Baklosan may be accompanied by the development of negative reactions and side effects from various organs and systems, these include:

  • Digestive system - nausea, vomiting, dry mouth, unstable stools (constipation or diarrhea).
  • Cardiovascular system - arterial hypotension (decrease in the level of systemic arterial pressure).
  • Central nervous system - fatigue, impaired consciousness in the form of confusion, apathy (lack of emotion and indifference to the world), depression (low mood), anxiety, ataxia (staggering gait) and hallucinations. Also, seizures of varying intensity can often develop.
  • Musculoskeletal system - myalgia (severe pain in the muscles), weakness in the muscles, tremor (trembling of the hands).
  • Eyes - nystagmus and spasm of accommodation (blurred vision when trying to focus on near and far objects).
  • The urinary system - the development of chronic renal failure with prolonged use of the drug, dysuria (painful urination, which often manifests itself as a burning sensation), enuresis (bed-wetting). Sometimes acute urinary retention may develop.

With the development of any manifestations of side effects, use of the drug must be stopped.

special instructions

Baklosan tablets are a potent drug, before using them it is necessary to carefully read the instructions, make sure that there are no contraindications and pay attention to a number of special instructions, which include:

  • Patients with liver disease must be periodically monitored for transaminase activity in the blood (markers of liver cell destruction).
  • Baklosan tablets enhance the therapeutic effect of drugs that affect the functional activity of the central nervous system and the effect of alcohol.
  • With prolonged use, it is necessary to carry out laboratory monitoring of the functional activity of the kidneys.
  • The active ingredient of the tablets Baklosan reduces the speed of psychomotor reactions and concentration.

In pharmacies, the drug is available only by prescription. Prescribes taking pills Baklosan doctor on the basis of a neurological examination. Also, the doctor regulates the dosage and duration of the drug.


Overdose

In case of exceeding the recommended therapeutic dose of tablets Baklosan, muscular hypotonia develops (excessive reduction of the strength and tone of the striated muscles), depression of the respiratory center of the medulla oblongata with a high risk of respiratory failure. When a significant overdose develops coma. At the same time, muscle hypotension and depression of the respiratory center may still persist for several days after the return of consciousness. There is no specific antidote to the active substance of the tablets. There is no lavage of the stomach and intestines and symptomatic therapy for overdose.

Baklosan Analogs

According to the active substance, the analogs of the Baklosan tablets are Baclofen, Lyoresal (rectal suppositories).

Terms and conditions of storage

The shelf life of tablets Baklosan is 3 years from the date of manufacture. The drug should be stored in a dry, dark place at an air temperature not exceeding + 25 ° C. Keep away from children.

Baklosan price

Corlosan tablets 10 mg, 50 pcs. - from 249 rubles.

Corlosan tablets 25 mg, 50 pcs. - from 440 rubles.

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