The Baclosan: instructions for use, price, reviews, analogs of tablets Baclossan
Medicine online

The

Baclosan user manual

Baclosan user manual

Baclosan is a pharmacological drug of the muscle relaxants. It reduces the tone and tension of the striated muscles. Used to reduce the severity of muscle spasm, stress and for muscle relaxation in various diseases of the central nervous system.

Form of issue and composition

The drug Baclosan is manufactured in the form of round, biconvex tablets of white color. The active substance of the drug is baclofen, which is contained in a concentration of 10 mg and 25 mg in one tablet. It also includes such auxiliary substances as:

  • Potato starch.
  • Lactose.
  • Gelatin.
  • Magnesium stearate.
  • Talc.
  • Ethyl cellulose.

Tablets are packaged in plastic bottles in an amount of 50 pieces. One cardboard pack contains one plastic bottle. This packing provides a long course of application of Baclosan tablets.



pharmachologic effect

Active substance tablets Baclosan baclofen is a derivative of gamma-aminobutyric acid. It refers to the pharmacological group of drugs - muscle relaxants of central action. Baclofen has antispastic (relieves muscle spasm) and muscle relaxant (relaxes the striated muscle) action due to such pharmacological effects:

  • Reduces the excitability of sensitive (afferent) nerve fibers of the spinal cord and brain, which reduces the excitability and readiness of the nervous system to develop muscle cramps.
  • Suppresses the functional activity of intermediate neurons, which are responsible for the transfer of impulses to motor (afferent) nerve fibers.
  • Reduces the preliminary stress of the striated muscle fibers.

Due to such pharmacological effects of the active ingredient, Baclosan tablets reduce the convulsive readiness of the muscles, reduce the contractile tension in them, increase the volume of movements in the joints due to relaxation of the muscle fibers (muscle relaxation). Directly on the neuromuscular transmission of the impulse in the appropriate synapses the drug does not affect.

After taking the pill inside, the active substance is absorbed into the blood and reaches a therapeutic concentration in it after 20-30 minutes. The maximum concentration in the blood is achieved in 2-3 hours. The bioavailability of baclofen is quite high. It penetrates well through the blood-brain barrier and accumulates in the tissues of the central nervous system. Also, the active substance of tablets Baclosan penetrates well through the placental barrier and can accumulate in the developing fetus during pregnancy. Baclofen is excreted in breast milk during lactation. Metabolism occurs in the liver, metabolites (metabolic products) and unchanged active substance are excreted from the body by the kidneys with urine.

Indications for use

Baclosan tablets are used in the complex therapy of pathological conditions, which are accompanied by an increased tone of different groups of striated muscles. Such diseases include:

  • Multiple sclerosis is a degenerative chronic disease of the structures and nerve fibers of the central nervous system, accompanied by the development of foci of increased nervous excitability.
  • Malignant or benign neoplasms of the spinal cord or brain, which affect to varying degrees the motor centers and intermediate neurons.
  • Infectious pathology of the spinal cord or brain.
  • Syringomyelia, which is accompanied by a violation of the synthesis of the membranes of nerve fibers with a change in the processes of impulses in them.
  • Stroke of the brain affecting the motor centers.
  • The transferred trauma of the central nervous system organs is a closed or open craniocerebral trauma, trauma of the spine and spinal cord.
  • Children's cerebral palsy (cerebral palsy) is a consequence of acute hypoxia (insufficient supply of oxygen) of the brain in the perinatal period with the development of a pronounced spasm of the striated musculature.
  • Meningitis - an inflammatory process in the membranes of the spinal cord or brain, affecting the functional activity of the structures of the central nervous system.
  • Chronic alcoholism, which develops alcoholic toxic damage of various structures of the brain and spinal cord.

Indications for the use of Baclosan tablets are set individually after an appropriate neurological examination.

Contraindications for use

Receiving tablets Baclosan is contraindicated in the presence of such pathological or physiological conditions of the body:

  • Hypersensitivity or individual intolerance of the active substance or an auxiliary component of the drug.
  • Epilepsy is a severe pathology of the central nervous system, which is characterized by the development of attacks of pronounced tonic-clonic seizures.
  • The presence of convulsive seizures in the past.
  • Psychosis is an acute disruption of the functional activity of the cerebral cortex, accompanied by the development of hallucinations, motor and speech excitement, and the appearance of delusional thoughts.
  • Parkinson's disease is a marked violation of the transmission of nerve impulses between the motor structures and the centers of the brain, spinal cord.
  • Acute or chronic renal failure, which dramatically reduces the excretion of metabolites and unchanged active substance from the body.
  • Pregnancy at any time and breastfeeding (if necessary, the drug during breastfeeding, the child is transferred to the reception of artificial adapted milk formulas, for the period of application of tablets Baclosan).

With care, Baclosan tablets are used for cerebrovascular insufficiency (a decrease in the volume and intensity of blood circulation in the brain), with peptic ulcer of the stomach or duodenum, in the elderly and children younger than 12 years.


Dosage and route of administration

Baclosan tablets are taken internally as a whole after a meal, they are washed down with a sufficient amount of liquid. Dosage and duration of treatment the doctor sets individually. The average therapeutic dose of the drug depends on the age, they are:

  • Children aged 1-2 years - 10-20 mg per day.
  • Children aged 2 to 6 years - 20-30 mg per day in several receptions.
  • Children aged 6-10 years - 30-60 mg per day.
  • Children over the age of 10 years - the calculation of the dose is based on the recommendation of 2 mg of active ingredient per 1 kg of body weight of the child per day.
  • Adults - the initial vine is 5 mg 3 times a day. Then, for several days, it is increased to achieve a therapeutic effect (usually up to 30-75 mg per day). The maximum daily dose is 100 mg per day.
  • People over the age of 65 years are doses the same as for adults, but the increase in the therapeutic dose is carried out gradually, for a longer time and under constant monitoring of laboratory indicators of the functional activity of the liver and kidneys.

The course of the drug is long enough, in each case, his doctor sets individually, depending on the underlying pathology, age of the patient and his general condition.

Side effects

Baclosan tablets can be accompanied by the development of negative reactions and side effects from various organs and systems, they include:

  • The digestive system - nausea, vomiting, dry mouth, unstable stool (constipation or diarrhea).
  • Cardiovascular system - arterial hypotension (decrease in the level of systemic arterial pressure).
  • The central nervous system - increased fatigue, impaired consciousness in the form of its confusion, apathy (lack of emotions and indifference to the outside world), depression (depression of mood), anxiety, ataxia (staggering gait) and hallucinations. Also, convulsions of different intensity can often develop.
  • Musculoskeletal system - myalgia (severe pain in the muscles), weakness in the muscles, tremor (trembling of the hands).
  • Eyes - nystagmus and accommodation spasm (visual impairment when trying to focus on near and far subjects).
  • The urinary system - the development of chronic renal failure with prolonged use of the drug, dysuria (painful urination, which often manifests itself as a burning sensation), enuresis (bedwetting). Sometimes acute urinary retention may develop.

With the development of any manifestations of side effects, the use of the drug should be discontinued.

special instructions

Baclosan tablets are a potent drug, before using them, it is necessary to carefully study the instruction, to make sure there are no contraindications and to pay attention to a number of special instructions, which include:

  • Patients with liver pathology are periodically monitored for transaminases in the blood (markers of destruction of liver cells).
  • Baclosan tablets enhance the therapeutic effect of drugs that affect the functional activity of the central nervous system and the effects of alcohol.
  • With prolonged use, it is necessary to carry out laboratory monitoring of the functional activity of the kidneys.
  • The active substance tablets Baclosan reduces the speed of psychomotor reactions and concentration of attention.

In pharmacies, the drug is dispensed only on prescription. The doctor appoints the doctor Baclosan on the basis of a neurological examination. Also, the doctor regulates the dosage and duration of the drug.

Overdose

If the recommended therapeutic dose of Baclosan tablets is exceeded, muscle hypotension develops (excessive decrease in strength and tone of the striated muscle), depression of the respiratory center of the medulla oblongata with a high risk of stopping breathing. When a significant overdose develops a coma. In this case, the hypotonia of the muscles and the depression of the respiratory center may still persist for several days after the return of consciousness. There is no specific antidote to the active substance of the Baclossan tablets, an overdose is followed by washing of the stomach, intestines and symptomatic therapy.

Baclosan Analogues

According to the active substance, the analogues of Baclosan tablets are Baclofen, Liorasal (rectal suppositories).

Terms and conditions of storage

The shelf life of Baclosan tablets is 3 years from the date of manufacture. The drug should be stored in a dry, protected from light place at an air temperature not exceeding + 25 ° C. Keep out of the reach of children.

Baclosan price

Baclosan tablets 10 mg, 50 pcs. - from 249 rubles.

Baclosan tablets 25 mg, 50 pcs. - from 440 rubles.

Evaluate Baclosan on a 5-point scale:
1 звезда2 звезды3 звезды4 звезды5 звезд (Votes: 1 , average rating: 5.00 of 5)


Reviews about the drug Baclossan:

The
Leave your feedback
    The
    The