Go Avamys Nasal Spray: instructions for use, price, reviews, analogues of allergy nasal spray Avamys
medicine online

Go

Avamys instructions for use

Avamys nasal spray Avamys is a nasal spray that is used to treat rhinitis, mainly of an allergic nature.

Despite the fact that the main active ingredient in this drug is a fluorinated corticosteroid (hormonal substance), it does not enter the systemic circulation and has only a local effect.

Active ingredient: micronized fluticasone furoate.

Latin name: Avamis.

Release form

Nasal spray containing 30, 60 or 120 doses of the drug (27.5 µg / dose).

Mechanism of action

Under the influence of fluticasone propionate in the nasal mucosa, the concentration of biologically active substances (cytokines, immunoglobilins) decreases. This leads to a narrowing of blood vessels, reducing swelling and secretion of glands.

Pharmacokinetics

Fluticasone propionate has the effect of "first pass" through the liver and intestines, with the result that the drug is quickly inactivated. This causes a minimal systemic effect of the drug.

Fluticasone propionate molecules are 99% bound to plasma proteins.

Clearance is 58 l / h, while the route of elimination of the drug is mainly hepatic (chemical transformations occur with the participation of the biological substance cytochrome P450). Inactive metabolites are excreted with feces.

The total bioavailability of Avamys does not exceed 0.5%.

Indications for use

Symptomatic pharmacotherapy of allergic rhinitis, arising both symptomatically and throughout the year.


Dosage and administration

The drug is used exclusively intranasally (i.e. injected into the nasal passages).

Children over the age of 12 years and adults are recommended the following scheme of Avamys use: 2 injections into each nostril once a day.

Children aged 6-11 years: 1 inhalation in each nasal passage once a day. If the effect of the application is insufficient, then you can increase the dose to 2 injections per day, but after the development of a full-fledged clinical effect, they again switch to a single use of the drug.

In elderly patients, as well as with symptoms of renal failure, dose adjustment is not required.

With reduced liver function, the rate of inhalation is determined by the attending physician after receiving biochemical analyzes.

The course of treatment is limited by the time the effect of the allergen on the patient. It is not advisable to use the drug as a prophylactic agent.

Proper use of the nasal spray: the vial containing Avamys is located in a plastic case, at the bottom of which there is a hole that allows you to control how much of the drug remains. On one of the sides is a valve, by pressing which the drug is sprayed.

Before using the vial or if the drug has not been used for more than 1 month, you should check the condition of the vial. To do this:

  • Without removing the cap, shake the bottle well (about 10 seconds).
  • Then remove the cap and, while holding the drug at some distance from yourself, test the spray by pressing the metering valve several times until a small cloud appears.

If the device is fully functional, then you can proceed to the intranasal inhalation:

  • First of all, the nasal passages must be cleaned.
  • Then tilt your head slightly forward and insert the tip deep into the nasal passage. At the same time, it should be directed not toward the nasal septum, but toward the outer wall of the nose.
  • Start to take a slow deep breath while simultaneously pressing the valve to dispense the preparation.
  • The first exhalation after inhalation is made by mouth.
  • Repeat the indicated inhalation sequence for the other nostril.
  • Be sure to tightly close the bottle cap.
  • It is necessary to ensure that the drug does not get on the mucous membrane of the eyes. Otherwise, they must be washed with plenty of warm water.

Proper care of the sprayer:

  • After each inhalation, the tip must be wiped dry with a dry soft cloth or napkin.
  • The tip of the tip can not be cleaned with sharp objects.
  • The protective cap should always be worn on the tip of the vial. Otherwise, the hole may be blocked by dust.

If the sprayer does not work:

  • First of all, you need to check the level of the remaining drug in the vial through a special window.
  • If the preparation is sufficient, then you should carefully inspect the nebulizer for damage, and also check that the tip is not clogged.
  • Try using the device again, as already described above.

Time of onset of effect: the initial effect of the use of Avamys develops 8 hours after the first inhalation. The maximum therapeutic effect is noted after 3-4 days of regular use of the spray.

Contraindications

  • Previously transferred allergic reactions to the active chemical substance.
  • Age under 6 years.
  • Prior therapy with ritonavir (this drug contributes to the manifestation of the systemic effects of fluticasone propionate).

Use during pregnancy

As prescribed by a physician, pregnant and nursing women can use Avamys with caution in the lowest possible doses.


Side effects

  • The development of ulcerative lesions on the mucous membrane of the nasal passages.
  • The occurrence of nasal bleeding (mild or moderate severity). Most often, this side effect occurs with prolonged use of the drug (more than 6 weeks).
  • Skin allergic reactions (itching, rash).
  • Allergic reactions of immediate type ( angioedema , development of anaphylactic shock).
  • Mental retardation in young children who have been inhaled with Avamys for a long period. In this regard, if necessary, long-term therapy data indicated tool is recommended to regularly measure the growth of the child. In the case when the lag on the specified anthropometric indicator begins to be registered, the dose is either reduced to the minimum effective, or the drug is canceled altogether.

Interaction with other drugs

Avamys can be combined with any medication, even with those that affect cytochrome P450, such as ketoconazole. In the latter case, the elimination of fluticasone propionate from the bloodstream is somewhat slower, but this fact has no clinical significance

Overdose

In the experiment conducted on volunteers, even multiple doses of the drug over a period of three days did not lead to the appearance of side effects.

Storage conditions

The preparation should be stored at a temperature not lower than 15 0 С in a shaded place. The unopened bottle is valid for three years from the date of manufacture. After the first use, the drug retains its activity for only 2 months.

Analogues of Avamys

Beclomethasone, Tafen Nazal, Nasobek, Polydex with Phenylephrine, Nazonex, Nazarel, Beconaze, Nasofan, Seroflo, Fliksonaze, Flohal, Flutinex, Flutisan

Price for Avamys

Avamys 27,5mkg / dose 120dose nasal spray - from 550 rubles.

Rate Avamys on a 5-point scale:
1 звезда2 звезды3 звезды4 звезды5 звезд (votes: 1 , average rating 5.00 out of 5)


Reviews of the drug Avamys:

Go
  • | Oksana | September 5, 2015

    Allergy helps me. My assessment of the drug - a strong five.

Leave your feedback
    Go
    Go