Atoris user manual
Atoris is a lipid-lowering drug from the statin group.
Active substance of the drug is atorvastatin. Atoris is available in the form of tablets in a dosage of 10, 20, 30 and 40 mg.
As auxiliary substances, calcium carbonate, povidone, cellulose, lactose, magnesium stearate are used.
Atoris contribute to the provision of such pharmacological effects:
- Reduces the level of low-density lipoprotein cholesterol, triglycerides.
- Increases the content of high density cholesterol-lipoproteins.
- Has antiatherosclerotic effect - positively affects the walls of blood vessels.
- Helps reduce blood viscosity, normalizes the process of blood coagulability.
- Helps prevent possible rupture of atherosclerotic plaque.
The therapeutic effect of Atoris develops after 2 weeks of regular intake of tablets, the maximum effect of the drug - after 1 month.
Indications for admission
Indications for the admission of Atoris are:
- Development of hyperlipidemia: primary, combined, family endogenous hypertriglyceridemia, resistant to diet therapy, homozygous familial hypercholesterolemia.
- Carrying out the prevention of cardiovascular diseases (primary and secondary). Primary: the drug is used in the complex treatment of patients at risk: people older than 56 years, patients with nicotine dependence, high blood pressure, diabetes, low cholesterol-high-density lipoproteins, genetic predisposition.
Secondary: prevention of possible complications in patients with coronary heart disease in order to reduce the risk of death, the development of myocardial infarction, stroke.
Atoris can not be used for individual intolerance of the active or auxiliary substances of the medicine, liver diseases at the stage of exacerbation (with chronic hepatitis, alcoholic hepatitis), liver failure, liver cirrhosis of various origin, with increased activity of hepatic transaminases, skeletal muscle diseases, with lactase deficiency, lactose intolerance, malabsorption syndrome.
The drug is also not recommended for admission during childbearing, breastfeeding and patients younger than 18 years of age.
Dosing and Administration
During the entire period of therapy, the patient must adhere to the basic principles of the lipid-lowering diet.
Obesity patients are recommended the following: before starting the use of the drug Atoris should try to normalize the level of cholesterol by the impact of moderate physical exertion and the treatment of the underlying cause of the disease.
Atoris I take inside, regardless of the meal. The initial dose is 10 mg.
As necessary, the dosage can be increased to 80 mg. The exact dose of the medicine is selected by the attending physician, taking into account the results of the examination and the initial level of cholesterol.
Recommended daily single dose, preferably at the same time. Dosage should not be adjusted sooner than 1 month after the start of use of the drug.
During treatment, it is necessary to regularly monitor the level of lipids in the blood plasma. The procedure should be carried out at least once every 2-4 weeks.
Correction of dose for patients of older age groups is not required.
Atoris is used as an auxiliary element of treatment together with other methods of therapy (plasmapheresis). The drug can also be used as the main component of therapy, if other methods of treatment and medicines do not have the necessary therapeutic effect.
Atoris can cause the development of such side effects: headache, dizziness, insomnia, tinnitus, heart palpitations, migraines, development of pain in the chest, constipation, dyspepsia, nausea, vomiting, bloating, myalgia arthralgia, back pain, swelling joints, skin rash, urticaria.
In case of development of undesirable by-effects the reception of a preparation should be stopped and consult with the doctor. You may need to reduce the dose or change the treatment schedule.
With the simultaneous use of Atoris (10 mg) with diltiazem (more than 200 mg), an increase in the concentration of Atoris in the blood plasma can be observed.
The risk of complications increases when Atoris is used in conjunction with fibrates, nicotinic acid, antibiotics, antifungal agents.
The effectiveness of Atoris decreases with simultaneous use with drugs Rifampicin and Phenytoin.
With simultaneous use with antacids, which include aluminum and magnesium, a decrease in the concentration of Atoris in the blood plasma is observed.
Admission of Atoris in conjunction with grapefruit juice can help increase the concentration of the drug in the blood plasma. Patients who are taking Atoris should remember that the use of grapefruit juice in a volume of more than 1 liter a day is unacceptable.
On the background of Atoris, the risk of developing myalgia increases. Patients should be under constant medical supervision. In cases where there are complaints of weakness and the development of muscle pains, the use of Atoris is immediately stopped.
The composition of the drug includes lactose, this should be taken into account for patients with lactose intolerance and lactase deficiency.
The drug Atoris should be used with extreme caution by patients suffering from alcoholism and in the event that there is a history of abnormal liver function.
In the event that there are manifestations of myopathy, the use of Atoris must be discontinued.
Atoris can promote the development of dizziness, so during treatment should refrain from driving and activities requiring increased concentration.
Atoris analogues are the following medicines: Liprimar, Atorvastatin-Teva, Torvacard, Liptonorm. If it is necessary to choose a replacement, it is recommended to consult a doctor beforehand.
The drug should be stored in a dark, dry place, protected from direct sunlight. The optimum storage temperature is up to 25 degrees.
The cost of the drug Atoris was formed as follows:
- Tablets 10 mg, 30 pcs. - 360-390 rub.
- Tablets 10 mg, 90 pcs. - 690-700 rub.
- Tablets 20 mg, 30 pcs. - 470-500 rub.
- Tablets of 20 mg, 90 pcs. - 1130-1170 rub.
- Tablets 40 mg, 30 pcs. - 640-650 rub.