Atacand: instructions for use
Atacand (Atacand) is a representative of antihypertensive agents from the group blocking angiotensin II receptors (AT1-subtype), which effectively reduces blood pressure.
Release form and composition:
Atacand comes in the form of pink biconvex tablets with a risk and engraved on both sides, which depends on the dose of the active substance.
In a tablet containing Cilexetil candesartan 8 mg, on the one hand, the engraving “008” is visible, and on the other “A” above the line and “CG” below the line.
A tablet containing 16 mg of cilexetil candesartan has the inscription “016” on one side, and on the opposite side, “A” above the line and “CH” below the line.
The tablet containing 32 mg of cilexetil candesartan has the inscription “032” on the one hand, on the other - “A” above the line and “CL” below the line.
Auxiliary ingredients: carmellose calcium salt (carmellose calcium), lactose monohydrate, corn starch, magnesium stearate, iron dye red dioxide, hydroxypropylcellulose, macrogol.
Mechanism of action:
Atacand (candesartan) is one of the modern means of blocking the effect of angiotensin II on AT 1 receptors. Angiotensin II plays a key role in the pathological process of hypertension, heart failure and other vascular diseases. It is this hormone that helps to reduce the lumen of the vessels due to the narrowing effect, the additional production of aldosterone, which leads to fluid retention in the bloodstream and tissues. The effect of angiotensin II on receptors located mainly in the vessels and tissues of the body leads to a sharp increase in blood pressure.
After applying a therapeutic dose of candesartan, peripheral vascular resistance decreases. At the same time, a tangible effect on the heart rate is not observed. Due to the fact that Atacand does not block the angiotensin-converting enzyme, patients practically do not have a cough. The antihypertensive effect develops over two hours and lasts throughout the day. The maximum effect of candesartan develops within one month.
It is proved that Atacand reduces mortality, as well as the development of such dangerous states as myocardial infarction and stroke. Prolonged use of the drug does not adversely affect glucose levels and lipid metabolism.
Indications for use:
- arterial hypertension;
- violation of the contractile function of the left ventricle against the background of heart failure;
- additional or alternative therapy for the use of angiotensin-converting enzyme inhibitors.
- increased individual sensitivity to candesartan or one of the auxiliary components;
- the period of pregnancy and breastfeeding;
- age up to 18 years.
With caution, the drug is used for pronounced disorders of the kidneys, liver and cholestasis, chronic heart failure, renal artery stenosis, aortic or mitral valve, hyperkalemia, reduced blood volume.
Dosing and Administration
Atakand is taken orally once a day, regardless of the meal.
In hypertension, the initial dose of candesartan is 8 mg. If necessary, the dose can be increased to 16 mg per day. To enhance the effect of Atacand, you can use diuretic drugs, angiotensin-converting enzyme inhibitors or beta-blockers.
Atakanda dose adjustment when used in old age is not needed. For severely impaired renal or liver function, treatment should begin with 4 mg of candesartan.
In case of heart failure, candesartan is started with 4 mg. The dose can double every two weeks and reach 32 mg per day.
At therapeutic doses, Atacand is usually well tolerated. In certain cases, the following negative effects may occur:
- headache, dizziness, weakness;
- lumbago, back pain, muscle and joint pain;
- flu-like symptoms: rhinitis, cough, sore throat, increased likelihood of respiratory infections;
- nausea, abdominal pain;
- allergic reactions: rash, urticaria , pruritus;
- impaired renal function and liver;
- increase in the concentration of potassium, sodium, creatine and urea in the blood.
In cases of overdose, there is a sharp decrease in blood pressure. Usually such conditions require symptomatic treatment and rarely need serious medical care.
Analogs of Atakanda
Kandesar, Angiakand, Kandekor, Kandesartan, Kasark, Khizart, Ira-sanovel, Advant.
Terms and conditions of storage
The drug should be kept out of the reach of children at a temperature not higher than 30 0 C. Atacanda has a shelf life of 36 months.
Atacand tablets 8 mg, 28 pcs. - from 1233 rubles.
Atacand tablets 16 mg, 28 pcs. - from 1508 rubles.
Atacand tablets 32 mg, 28 pcs. - from 1921 rubles.