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Anavenol dragee instructions for use

Anavenol dragee instructions for use

Anvenol is a medicinal product based on plant extracts, which has a veno-tonic effect and is used to treat chronic venous diseases. It belongs to the group of capillary-stabilizing drugs.

Release form and composition

The composition of Anvenol contains substances derived from plant extracts:

  • dihydroergocristine mesilate (ergot) - 0.58 mg;
  • esculina sesquihydrate (from horse chestnut) - 1.62 mg;
  • Rutozida trihydrate (from mint fragrant) - 32.66 mg.

Auxiliary components: lactose, povidone 25, sucrose, talc, titanium dioxide, croscarmellose sodium 20, polyvinyl acetate, corn starch, stearic acid, dyes.

The drug is available in the form of dragee, 60 pieces per pack. Also produced a liquid dosage form in the form of drops and coated tablets.

pharmachologic effect

Pharmacodynamics . Substances that are part of the drug, have a beneficial effect on the vessels. Dihydroergocristine is a semi-synthetic derivative of the alkaloid group. Blocks α-adrenoreceptors, thereby reducing the tone of smooth muscles and total peripheral vascular resistance. It helps to strengthen and improve the elasticity of the venous walls. Esculin and rutoside - substances of natural origin. Reduce the permeability and fragility of the vascular walls, have anti-inflammatory and anti-edema effect.

Pharmacokinetics. About 25% of dihydroergocristine is absorbed into the digestive tract. 68% of the active substance is bound to plasma proteins. The withdrawal period is 14 hours. Dihydroergocristine is excreted with bile. Penetrates through the placental barrier and is absorbed into breast milk.

Rutoside is absorbed into the blood. Its maximum concentration in the blood is reached in 1–9 hours. The elimination half-life of ruthoside is 10–25 hours. It is displayed mainly in the form of metabolites, a small part - in unchanged form.

Data on the pharmacokinetics of esculin are not available.

Indications for use

Anavenol is prescribed for various pathologies of venous vessels, namely:

  • chronic venous insufficiency (blood stasis in the veins of the lower extremities);
  • varicose veins disease (varicose veins);
  • precursory syndrome - feeling of “tired” legs (precedes the development of varicose veins);
  • mechanical damage to the veins;
  • thrombosis of deep veins of the lower extremities in the initial stages;
  • trophic tissue lesions (trophic ulcers) on the background of angiopathy, diabetes mellitus, thrombophlebitis;
  • inflammatory processes in the veins;
  • impaired blood circulation in the vessels of the lower extremities caused by injuries or prolonged forced immobility.

Contraindications

The use of Anvenol is contraindicated in:

  • any bleeding;
  • individual intolerance to the components of the drug;
  • under the age of 15;
  • organic lesions of the liver and kidneys.

Dosing and Administration

Anavenol can be administered both in complex treatment and independently. Pills are taken orally after a meal, without chewing, with a small amount of liquid.

In the first week of treatment, 2 tablets are taken 3 times a day, then a maintenance dosage is prescribed - 1 tablet three times a day. The duration of the therapeutic course is determined by the doctor, on average, supportive therapy lasts 2-3 months.

Side effects

The drug is well tolerated. But sometimes the use of Anavenol can cause unwanted side effects:

  • allergic reactions - pruritus, rash, urticaria;
  • headache and dizziness, fatigue, decreased concentration and attention, speed of psychomotor reactions;
  • nausea and vomiting, diarrhea;
  • swelling of the nasal mucosa;
  • menorrhagia (excessively heavy menstruation);
  • metrorrhagia (irregular uterine bleeding).

If you experience side effects, you should immediately cancel the drug and consult a doctor.

In case of an overdose of Anavenol, blockage of vessels of the mucous membranes, dyspeptic symptoms (diarrhea, nausea and vomiting), dizziness, loss of consciousness, tremor are possible. Specific antidote to the drug does not exist. When symptoms of overdose appear, gastric lavage is performed, sorbents and drugs for symptomatic treatment are prescribed (depending on the clinical signs of overdose). Symptomatic treatment is aimed at restoring the normal functioning of the cardiovascular system and the water-salt balance in the body.

special instructions

Anavenol is used with caution when:

  • severe liver disease;
  • severe renal impairment;
  • hypotension (low blood pressure);
  • heart failure;
  • bradycardia (heart rate below 60 beats per minute).

When managing transport and other mechanisms, work requiring speed of reaction and concentration of attention, it is better to refuse from taking Anvenol.


Use during pregnancy and lactation

The drug can be administered in the second half of pregnancy after assessing the ratio of benefits to the mother and the risk to the fetus. In the first half of pregnancy, as well as during the breastfeeding period, Anavenol is not used.

Interaction with other drugs

Simultaneous use of Anavenol with other drugs may increase or decrease the therapeutic effect of drugs. The action of Anvenol is enhanced when applied simultaneously with:

  • certain antibiotics (erythromycin, tetracycline, oleandomycin, doxycycline);
  • vasodilators (nitroglycerin, papaverine, no-spa, propranolol, caffeine, nadolol, aminophylline);
  • other means (salbutamol, fenoterol, phentolamine).

The action of Anvenol is reduced when taken simultaneously with α-stimulants and preparations of the vasoconstrictors group.

The combination of Anavenol with reserpine can cause a sharp decrease in blood pressure.

Terms and conditions of storage

The drug is stored in a dark place inaccessible to children at a temperature not higher than 25 ° C. Shelf life - 3 years.

Analogs

Drugs similar to Anavenol in composition are not currently available. Medicines that have a different composition, but which have an Anavenol-like effect, include: Venoplant, Escuzan, Venen, Glevenol, Dicvertin, Payleks, Estsizan, Cyclo 3 Forte.

Price Anavenol

Anavenol dragee, 60 pcs. - from 166 rubles.

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