Anastrozole instructions for use
The tool belongs to the group of anticancer drugs. The substance anastrozole is considered to be an antagonist of sex hormones and a selective nonsteroid aromatase inhibitor. Inhibits the synthesis of estrogen. When used in therapeutic doses, there is a significant decrease in estradiol levels. Anastrozole is used in the treatment of estrogen-dependent tumors. After taking the absorption of the drug reaches 85%. Parallel ingestion of food reduces this figure, so the use of food with anastrozole is undesirable.
Release form and composition
The drug is available in the usual tablet form. The number of tablets per pack is 28 or 56 pieces. The active ingredient is anastrozole at a dosage of 1 mg. In addition, the composition of the drug includes additional components: lactose monohydrate, povidone - K30, titanium dioxide, magnesium stearate, macrogol 6000, macrogol 4000, sodium carboxymethyl starch and hypromellose.
Indications for use
Anastrozole is prescribed in the presence of such diseases:
- early stages of breast cancer, which was detected in the post-menopausal period and depends on the effects of hormones;
- breast cancer during menopause;
- lack of effect in the treatment of breast cancer with the use of tamoxifen.
Anastrozole can not be used in the detection of hypersensitivity to it or other components in the composition. The tool is not prescribed in the premenopausal period and during treatment with tamoxifen. Breast feeding and state of pregnancy are considered to be a strict contraindication. In addition, to refrain from anastrozole therapy should be in renal failure, severe liver disease and while taking drugs containing estrogen. Some restrictions apply to people with a history of diseases such as osteoporosis, coronary heart disease and hypercholesterolemia.
Dosing and Administration
The recommended dosage is 1 tablet per day. The duration of the course can vary quite significantly. The drug is prescribed after a thorough examination of the patient, and its use requires periodic monitoring of blood parameters. If the drug is used in the indicated dosage, then after 24 hours estradiol indices decrease to 70%. After 14 days, the reduction reaches 80%.
Anastrozole can cause negative side effects. There have been cases of such complications:
- drowsiness and asthenic syndrome;
- sleep disorders in the form of insomnia;
- pain behind the sternum, accompanied by anxiety and dryness in the mouth;
- the occurrence of various types of anemia;
- vomiting or constant nausea with dizziness;
- muscle pain;
- increased sweating;
- the occurrence of depressive manifestations;
- permanent headache;
- shifts in blood counts, leukopenia;
- flu-like condition;
- sinusitis or pharyngitis ;
- erythema rash;
- vaginal bleeding;
- lack of appetite;
- impaired mobility of the joints;
- unstable back pain;
- change in the appearance of hair on the head, alopecia;
- the occurrence of edema of different localization;
- sudden nasal congestion;
- increased levels of AST and ALT. This complication most often occurs when treating patients who have metastases to the liver;
- Stevens-Johnson syndrome;
- itching of the whole body or particular areas;
- increase in alkaline phosphatase;
- high blood pressure;
- stool disorders that manifest as diarrhea or persistent constipation, requiring the use of laxatives;
- vaginal dryness;
- quick weight gain.
Anastrozole can not be administered independently. His reception requires a thorough preliminary examination with the collection of the patient's history. Strict ban to the start of therapy is the suspicion of pregnancy. It is considered mandatory to conduct tests confirming the state of menopause. The occurrence of bleeding should be a reason for immediate treatment to the doctor. It is proved that the tool helps to reduce the density of the tissues of the musculoskeletal system. It must be remembered that the effectiveness of treatment with Anastrozole decreases significantly with the parallel use of drugs, which include estrogens. It is also impossible to take a joint reception with tamoxifen. It makes no sense to use Anastrozole for tumors that are not considered estrogen-dependent. This therapy will be useless. Drowsiness, often occurring at admission, requires a temporary refusal from driving and working with increased concentration of attention. With the concurrent intake of warfarin and anastrozole, no negative effects were identified, the indicators of anticoagulant activity were unchanged. Data on the joint intake of anastrozole and drugs - there are no analogues to LHRH. Information that chemotherapy, carried out together with the reception of anastrozole, somehow affects the effectiveness of treatment, has not been confirmed.
There is no data on the exact dose of anastrozole that can lead to life-threatening symptoms. Isolated cases of overdose were recorded. There is no specific antidote. When symptoms of overdose appear, symptomatic treatment is recommended in the form of vomiting stimulation, as well as laboratory monitoring of systemic indicators. Dialysis is allowed.
Terms and conditions of storage
Anastrozol does not require specific storage conditions. Shelf life is 5 years. The product can be stored in its original packaging at a temperature that does not exceed 30 degrees Celsius.
Analogs of tablets Anastrozol
The list of drugs with the active substance Anastrozole is quite extensive. The most well-known and well-proven are: Anastrozole - Teva, Aksastrol, Egistrazol, Mammozol, Vero - Anastrozole, Anabrez, Anastrozole Kabi, Celana, Anastrex and Anabrez.
The price of Anastrozole in pharmacies in Moscow
Anastrozole tablets, film coated 1 mg, 28 pcs. - from 1050 rubles.