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Anafranil: instructions for use

Anafranil: instructions for use

Anafranil is a drug that has an antidepressant effect.

Release form and composition


The drug is available in the form of tablets, coated with a light yellow shell, sweet in taste. Tablets biconvex and round.

Each tablet contains clomipramine hydrochloride 25 mg. Lactose, corn starch, stearic acid, silicon dioxide, magnesium stearate, talc are used as auxiliary substances.

Anafranil Wed

The drug is available in the form of tablets with prolonged action, coated with a pink shell. Capsule tablet, biconvex, has a risk on both sides. One side of the tablet is labeled “CG” and the other side is “FH”.

Each tablet contains clomipramine hydrochloride 75 mg. Calcium hydrophosphate dihydrate, calcium stearate, polyacrylate, silicon dioxide, titanium dioxide, talc, iron oxide red are used as excipients.


With oral administration, clomipramine is completely absorbed through the gastrointestinal tract. Eating does not affect the effectiveness of the drug. The degree of communication with plasma proteins is 97%. Clomipramine penetrates into the cerebrospinal fluid (2%), into the mother's milk in the same concentration as in the blood plasma.

As a result of a single dose of Anafranil, 2/3 of clomipramine is excreted in the urine, and 1/3 in the feces.

pharmachologic effect

Anafranil's active ingredient is clomipramine, which has an antidepressant effect, as well as a pronounced sedative and moderate analgesic effect.

The drug is effective for bulimia in patients with depressive disorders, and without them.

Anafranil exhibits an antidepressant effect a week after the start of treatment. The drug is ineffective with narcoleptic drowsiness.

Indications for use

Anafranil is prescribed for various depressive states of an organic, neurotic, endogenous, involutional, reactive nature; with depression in patients with psychopathy and schizophrenia; in the treatment of depressive syndromes in the elderly.

The drug is used in the treatment of depressive conditions caused by prolonged pain, chronic pain syndrome in patients with cancer, phobias and panic fears, rheumatism, migraine, catalepsy, narcolepsy.

Anafranil is prescribed to children older than 5 years with obsessive-compulsive syndrome and nocturnal enuresis.

The efficacy and safety of treating depressive conditions in children and adolescents has not been sufficiently studied, so the use of Anafranil up to 17 years is not recommended for this indication.

Mode of application

The drug should be taken after meals or while eating food.

For phobias, depression, and obsessive states, take 1 tablet 2–3 times a day. Anafranil CP take 1 tablet in the evening. During the week, daily dosage is increased to 150 mg. After improving the condition, the patient is gradually transferred to maintenance therapy (2-4 tablets per day).

When narcolepsy daily dose is 25-75 mg.

With chronic pain, the daily dose is 10-150 mg per day.

To relieve fear attacks, 10 mg per day is prescribed in combination with benzodiazepines. Further the dose of anafranil is increased, and benzodiazepine is canceled. The duration of treatment should be at least six months.

For children, the drug is prescribed for 10 days, 10 mg per day. In children 5-7 years later, the dosage is increased to 20 mg, children 8-14 years old - up to 50 mg, children older than 14 years old - up to 50 mg and more.

Side effects

Anafranil use can cause tachycardia, hallucinations, decreased visual acuity, dry mouth, drowsiness, constipation, heavy sweating, anxiety, anxiety, aggressiveness, psychosis, nightmares, decreased concentration and memory impairment, arrhythmia, tremor, hypotension, nausea, vomiting, heartburn, hepatitis, malaise, irritability, tinnitus, sleep disturbance.

An overdose of the drug leads to drowsiness, insomnia, anxiety, epileptic seizures, tachycardia, confusion, impaired intracardiac conduction. Overdose symptoms appear 4 hours after taking the drug and persist for 4-6 days.

There is evidence that high dosages of Anafranil cause vomiting, shortness of breath, respiratory depression, anuria, and increased sweating. Treatment of overdose is carried out by washing the stomach, taking activated charcoal. With a decrease in pressure, arrhythmias and coma, cholinesterase inhibitors, anticonvulsants, are prescribed and artificial respiration is performed.


Anafranil can not be prescribed for heart attack, angle-closure glaucoma, drug and alcohol poisoning, severe conductivity disorders, lactation and pregnancy, children under 5 years of age.

We recommend caution, appointing the drug in chronic alcoholism, manic-depressive psychosis, asthma, deterioration of the hematopoietic bone marrow, hypertension, angina, heart chronic failure, heart block, arrhythmias, stroke, hepatic and renal failure, impaired GI motility, thyrotoxicosis, prostatic hyperplasia, urination disorders, epilepsy, schizophrenia, the elderly.

Pregnancy and lactation

Experience taking the drug during pregnancy is limited. There is evidence of a negative impact on the development of the fetus when taking tricyclic antidepressants, so it is not advisable to use Anafranil during pregnancy, excluding those cases where the benefits of treatment outweigh the risk to the fetus.

Interaction with other drugs

Anafranil combination with MAO inhibitors is not allowed. The combined use of these drugs can lead to such severe conditions as hypertensive crisis, fever, seizures and coma.

The combination of Anafranil with antiarrhythmic drugs, diuretic drugs and serotonic drugs is not recommended.

There are drugs that enhance the effect of Anafranil. These include terbinafine, cimetidine, oral contraceptives, antipsychotics, methylphenidate, valproate. Also, consumption of grapefruit, cranberry or grapefruit juice can lead to an increase in the concentration of the active substance in the blood.

Some interactions can weaken the effect of Anafranil - rifampicin or anticonvulsant drugs, colestipol and cholestyramine, smoking and the use of hypericum perforatum.

special instructions

Excess therapeutic dose of Anafranil leads to ventricular tachycardia.

In patients with panic disorders, first use of Anafranil causes an increase in anxiety, which decreases after 2 weeks.

Patients suffering from severe depression and taking antidepressants should be carefully monitored, since suicidal behavior and other psychiatric symptoms may occur.

If necessary, local or general anesthesia should inform the anesthesiologist about the use of the drug Anafranil.

Prolonged use of an antidepressant can trigger the development of dental caries.

Co-administration of diuretics can lead to the development of hypokalemia.

The drug is not recommended to abruptly cancel, because it will lead to adverse reactions.

The use of alcohol during treatment Anafranila enhances the negative effects of the central nervous system, which can lead to deterioration of vision and drowsiness.

In the event of blurred vision, drowsiness and other disorders of the central nervous system, patients should not drive vehicles, work with mechanisms and perform work requiring increased attention.

Storage conditions

The drug is recommended to be stored at a temperature of 25 ° C, in a dry place inaccessible to children.

Analogs Anafranila

Clominal, Clofranil, Clomipramine, Clomipramine

Anafranil prices

Anafranil tablets, coated 25 mg, 30 pcs. - from 297 rubles.

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