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Ampisid powder for injection: instructions for use

Ampisid injections

ATX Code: J01CR01.

Form release: powder for solution for injection.

Dosage form: free flowing white powder with a characteristic specific smell. The solvent is a colorless transparent liquid.

Clinico-pharmacological group: a broad-spectrum antibacterial drug of the penicillin group with beta-lactamase inhibitor.

Pharmacotherapeutic group: Ampicillin and Sulbactam double ester, a derivative of 6-aminopenicillic acid.

Packaging: glass bottle, ampoule with solvent, cardboard box.


Active ingredient : ampicillin sodium, sodium sulbactam.

Solvent: lidocaine hydrochloride.


The drug has a bactericidal effect on gram-positive and gram-negative aerobic and anaerobic bacteria, inhibiting the biosynthesis of peptoglycans of the bacterial cell membrane. Ampicillin double ester readily disintegrates under the influence of beta-lactamase, and sulbactam irreversibly inhibits a group of bacterial enzymes aimed at combating penicillin antibiotics.

Active against Gram and Bone and Enterobacter spp., Neisseria meningitidis, Neisseria gonorrhoeae and anaerobes.


After intravenous or intramuscular administration, the drug components are distributed in the pleural, parietal, synovial fluids, bronchial secretions, secretions of the nasal sinuses, saliva, and also in the body tissues (in the lungs, palatine tonsils, middle ear, ovaries, uterus, liver, prostate gland, muscle tissue, gall bladder). Ampiside is able to penetrate the blood-brain barrier (with inflamed meninges).

Maximum concentration in plasma reaches in 1-2 hours. The binding of the active substance to plasma proteins is 28% (ampicillin) and 38% (sulbactam). The half-life is 45 minutes and 1 hour, respectively. In patients with renal impairment, elderly people and newborns T1 / 2 is longer. About 55-75% of Amphisides is excreted by the kidneys, a small part - by the intestines, along with feces. When inflammation of the pia mater, the drug is able to penetrate the blood-brain barrier, is removed during hemodialysis.

Indications for use

  • Infections of the upper and lower respiratory tract;
  • Gynecological diseases of bacterial etiology;
  • Infections of the skin and soft tissues;
  • Intraabdominal infections;
  • Inflammations of bone tissue and articular joints;
  • Urinary tract infections;
  • Gonorrhea ;
  • Postoperative prophylaxis after cesarean section and abortion;
  • Bacterial septicemia.

Method of preparation and dose

When preparing a drug for intravenous administration, a single dose of the drug is dissolved in 100-200 ml of 5-10% glucose or saline. When preparing a drug for intramuscular administration, the contents of the vial are dissolved with a 0.5% lidocaine solution (ampoule is attached).

Depending on the severity of the disease and the patient’s kidney function, the daily dose of ampisis can vary from 1.5 grams to 12 grams. In severe cases of the disease, injections are made every 6-8 hours, in milder cases, every 12 hours.

The duration of treatment is 5-14 days. After the disappearance of the clinical signs of the disease, the drug should be used for another 2 days.

Side effects

  • Soreness at the injection site;
  • Hyperemia or phlebitis (after intravenous administration);
  • Itching, urticaria , polymorphic erythema, epidermis necrolysis, anaphylactic shock (from ≥0.1% to <1%);
  • Nausea, vomiting, diarrhea, dyspepsia, enterocolitis, abnormal liver function, jaundice;
  • Eosinophilia, lymphocytosis, decrease in hemoglobin level, thrombocytosis, agrunulocytosis (from ≥0.1% to <1%);
  • Interstitial nephrosis;
  • Candidiasis;
  • Seizures (≥0.1% to <1%);
  • With reduced resistance of the organism, the development of superinfection is possible.

Drug interaction

Ampisid injections enhances the effect of anticoagulants (alters platelet aggregation and hemocoagulation indices.

It is an antagonist of drugs with a bacteriostatic effect (tetracyclines, sulfonamides, erythromycin and chloramphenicol) and a synergist of cephalosporins, aminoglycosides, rifampicin, vancomycin, cycloserine.

It reduces the effectiveness of oral contraceptives and drugs that form para-aminobenzoic acid in the process of metabolism.

Diuretics, NSAIDs, Probenecid, Allopurinol and other drugs that reduce tubular secretion, used in combination with Ampisid, increase the concentration of the antibacterial drug, extend its half-life and significantly increase the risk of its toxicity.

special instructions

The use of drugs of the penicillin group sometimes leads to the development of quite serious conditions, up to anaphylactic shock and death. Therefore, in the event of even minor allergic reactions, Ampisid should be noted and appropriate treatment given to the patient.

Patients with septic complications may develop a bacteriolysis reaction.

During treatment, the function of the liver, kidney and hematopoietic system should be constantly monitored. In this situation, excessive growth of microorganisms insensitive to Ampisid (including fungal microflora) is possible.


With an overdose of the antibiotic, dizziness, fatigue, headaches, drowsiness, general malaise, sleep disturbance, emotional lability, depression, increased anxiety are observed. At very high concentrations of the drug in the cerebrospinal fluid disrupts the normal functioning of the central nervous system, up to the development of seizures. Hemodialysis may be prescribed to speed up the elimination of ampiside in patients with renal insufficiency.

Terms of implementation

Ampiside, powder for solution for injection, refers to prescription drugs.

Storage conditions

Store in a dark, protected from light and moisture, out of the reach of children, at a temperature not exceeding 25 C.

Shelf life

The drug is usable for 3 years from the date of issue. Use of the product after the expiration date indicated on the package is prohibited.


  • Aprid;
  • Unazin.

The price of Ampisid powder for solution for injection

Ampisid powder for solution for intramuscular injection of 1000 mg + 500 mg - from 217 rubles.

Ampisid powder for solution for intravenous and intramuscular administration of 500 mg + 250 mg - from 95 rubles.

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