The Ampiside injections, powder for injections: instruction manual, price, reviews, analogs
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Ammiside powder for injection: instruction manual

Amphiside injections

ATX code: J01CR01.

Form release: powder for the preparation of solution for injection.

Dosage form: free-flowing white powder with a characteristic specific odor. Solvent is a colorless transparent liquid.

Clinico-pharmacological group: antibacterial preparation of a broad spectrum of action of a group of penicillins with an inhibitor of beta-lactamases.

Pharmacotherapeutic group: double ester of ampicillin and sulbactam, a derivative of 6-aminopenicillinic acid.

Packing: glass bottle, ampoule with solvent, cardboard box.


Actively active substance : ampicillin sodium, sodium sulbactam.

Solvent: lidocaine hydrochloride.


The drug has a bactericidal effect on Gram-positive and Gram-negative aerobic and anaerobic bacteria, inhibiting the biosynthesis of peptoglycans of the bacterial cell membrane. The double ester of ampicillin readily disintegrates under the influence of beta-lactamases, and sulbactam irreversibly inhibits a group of bacterial enzymes aimed at combating antibiotics of the penicillin series.

It is active against Gram-positive and Gram-negative bacteria, (Staphylococcus aureus and Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus faecalis et al., Haemophilus influenzae and Haemophilus parainfluenza, Branhamella catarrhalis, Escherichia coli, Klebsiella spp., Proteus spp., Morganella morganii, Citrobacter spp. and Enterobacter spp., Neisseria meningitidis, Neisseria gonorrhoeae and anaerobes.


After intravenous or intramuscular injection, the components of the drug are distributed in pleural, parietal, synovial fluids, bronchial secretion, secretion of nasal sinuses, saliva, and also in the body tissues (in the lungs, palatine tonsils, middle ear, ovaries, uterus, liver, prostate, tissue, gall bladder). Ammiside is able to penetrate the blood-brain barrier (with inflamed meninges).

The maximum concentration in plasma reaches in 1-2 hours. The binding of an active substance with plasma proteins is 28% (ampicillin) and 38% (sulbactam). The half-life is 45 minutes and 1 hour, respectively. In patients with impaired renal, advanced and newborn children, T1 / 2 is more prolonged. About 55-75% of Ammiside is excreted by the kidneys, a small part - by the intestine, along with feces. With inflammation of the soft medulla the drug is able to penetrate the blood-brain barrier, it is removed during hemodialysis.

Indications for use

  • Infections of the upper and lower respiratory tract;
  • Gynecological diseases of bacterial etiology;
  • Infections of skin and soft tissues;
  • Intra-abdominal infections;
  • Inflammation of bone tissue and articular joints;
  • Urinary system infections;
  • Gonorrhea ;
  • Postoperative prophylaxis after cesarean section and abortion;
  • Bacterial septicemia.

Method of preparation and dose

When preparing the drug for intravenous administration, a single dose of the drug is dissolved in 100-200 ml of 5-10% glucose or saline. When preparing the preparation for intramuscular injection, the contents of the vial are dissolved by 0.5% lidocaine solution (ampoule is attached).

Depending on the severity of the disease and the kidney function of the patient, the daily dose of Ammiside can vary from 1.5 grams to 12 grams. In severe illness, injections are done every 6-8 hours, in more mild cases - every 12 hours.

Duration of treatment is 5-14 days. After the disappearance of clinical signs of the disease drug should be used for 2 more days.

Side effects

  • Soreness at the injection site;
  • Hyperemia or phlebitis (after intravenous administration);
  • Itching, urticaria , erythema multiforme, necrolysis of the epidermis, anaphylactic shock (from ≥0.1% to <1%);
  • Nausea, vomiting, diarrhea, dyspepsia, enterocolitis, liver dysfunction, jaundice;
  • Eosinophilia, lymphocytosis, reduction of hemoglobin level, thrombocytosis, agrunulocytosis (from ≥0.1% to <1%);
  • Interstitial nephrosis;
  • Candidiasis;
  • Seizures (from ≥0.1% to <1%);
  • With reduced resistance of the body, it is possible to develop superinfection.

Drug Interactions

Ammiside injection increases the effect of anticoagulants (changes the aggregation of platelets and hemocoagulation indicators.

It is an antagonist of drugs possessing bacteriostatic action (tetracyclines, sulfonamides, erythromycin and chloramphenicol) and synergists of cephalosporins, aminoglycosides, rifampicin, vancomycin, cycloserine.

Reduces the effectiveness of oral contraceptives and drugs, forming in the process of metabolism para-aminobenzoic acid.

Diuretics, NSAIDs, Probenecid, Allopurinol and other drugs that reduce tubular secretion, used in conjunction with Ammiside, increase the concentration of antibacterial drug, prolong its half-life and significantly increase the risk of its toxicity.

special instructions

The use of drugs of the penicillin group sometimes leads to the development of quite serious conditions, up to anaphylactic shock and death. Therefore, if there are even minor allergic reactions, Ammiside should be noted and the patient should be treated accordingly.

In patients with septic complications, a bacteriolysis reaction may develop.

In the course of treatment, the function of the liver, kidneys and hematopoietic system should be constantly monitored. In this situation, excess growth of microorganisms insensitive to Ambiside (including fungal microflora) is possible.


When the antibiotic is overdosed, dizziness, fatigue, headaches, drowsiness, general malaise, sleep disturbance, emotional lability, a depressed state, increased anxiety are observed. At very high concentrations of the drug in the cerebrospinal fluid, the normal functioning of the central nervous system is disrupted, up to the development of seizures. To accelerate the elimination of Ammisid, hemodialysis can be prescribed to patients with renal insufficiency.

Terms of implementation

Ammiside, powder for solution for injection, refers to prescription drugs.

Storage conditions

Store in a dark place, protected from light and moisture, out of reach of children, at a temperature not exceeding 25 ° C.

Shelf life

The drug is suitable for use within 3 years from the date of manufacture. Do not use the product beyond the expiry date printed on the package.


  • Apyr;
  • Unazine.

Price for Ammiside powder for solution for injection

Ammiside powder for the preparation of solution for intramuscular injection 1000 mg + 500 mg - from 217 rubles.

Ammiside powder for the preparation of a solution for intravenous and intramuscular injection 500 mg + 250 mg - from 95 rubles.

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