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Ampisid suspension for children: instructions for use

Ampisid suspension for children

ATX Code: J01CR01.

Form release: powder for suspension.

Dosage form: white powder, white homogeneous suspension.

Clinico-pharmacological group: A broad-spectrum antibacterial drug of the penicillin group with beta-lactamase inhibitor.

Pharmacotherapeutic group: Ampicillin and Sulbactam double ester, a derivative of 6-aminopenicillic acid.

Packaging: bottle of yellow glass with a risk, sealed with an aluminum lid, measuring spoon, cardboard box.


Active ingredient: Sultamicillin tosylate dihydrate.

Auxiliary components: acetic anhydride, xanthan gum, sucrose, sodium dihydrogen phosphate, carmellose sodium, hyprolose, flavoring.


The drug has a bactericidal effect on gram-positive and gram-negative aerobic and anaerobic bacteria, inhibiting the biosynthesis of peptoglycans of the bacterial cell membrane. Ampicillin double ester readily disintegrates under the influence of beta-lactamase, and sulbactam irreversibly inhibits a group of bacterial enzymes aimed at combating penicillin antibiotics.

Active in the field of Gram-positive and Gram-negative. morganii, Citrobacter spp. and Enterobacter spp., Neisseria meningitidis, Neisseria gonorrhoeae and anaerobic bacteria.


Ampiside in the digestive tract breaks down into ampicillin and sulbactam (1: 1). Eating time does not have a significant impact on the bioavailability of the drug.

Maximum concentration in plasma reaches in 1-2 hours. The binding of the active substance to plasma proteins is 28% (ampicillin) and 38% (sulbactam). The drug is distributed to all tissues and body fluids. Quickly droops into the lung tissue, middle ear fluid, bronchial secretions, urine and bile. In high concentrations accumulates in the liver. Concentration in bile is 2 times higher than plasma concentration.

The half-life is 45 minutes and 60 minutes, respectively. In patients with renal impairment, elderly people and newborns T1 / 2 is longer. About 55-75% of Amphisides is excreted by the kidneys, a small part - by the intestines, along with feces. When inflammation of the pia mater, the drug is able to penetrate the blood-brain barrier, is removed during hemodialysis. It penetrates into the placenta and is excreted in breast milk.

Indications for use

  • Infections of the upper and lower respiratory tract;
  • Gynecological diseases of bacterial etiology;
  • Infections of the skin and soft tissues;
  • Intraabdominal infections;
  • Inflammations of bone tissue and articular joints;
  • Urinary tract infections;
  • Gonorrhea ;
  • Postoperative prophylaxis after cesarean section and abortion;
  • Bacterial septicemia.


The daily dose for adults and children over 5 years old, with a body weight of more than 30 kg is prescribed taking into account the age and severity of the disease (375-750 mg / day, divided into 2 times).

Children under 5 years old with a body weight of less than 30 kg per day are prescribed 50 mg per 1 kg of weight, divided into 2 doses.

The average duration of treatment is 5-14 days. After the disappearance of the clinical signs of the disease, the drug should be used for another 2 days.

The method of preparation of the suspension

The powder is dissolved with boiled water, cooled to room temperature. The volume of liquid is adjusted to the mark in the vial, shaking occasionally. Finally, to dissolve the liquid completely, they are allowed to stand for 5 minutes. Before each use, the vial is thoroughly shaken. After dilution, the antibacterial mixture is stored in the refrigerator for no more than two weeks. Freezing is not allowed.

Side effects

On the part of the skin : itching, urticaria , erythema multiforme.

On the part of the digestive tract : nausea, diarrhea, glossitis, enterocolitis, pseudomembranous colitis (rarely).

On the part of the hematopoietic system : decrease in hemoglobin level, lymphocytosis, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytosis (from ≥0.1% to <1%).

On the part of the urinary system : interstitial nephrosis (from ≥0.1% to <1%).

Other : with long-term use of the drug - vaginal candidiasis, in patients with low resistance of the body may develop superinfection.

Drug interactions

The drug enhances the action of anticoagulants (changes platelet aggregation and hemocoagulation).

Ampisid is an antagonist of drugs with a bacteriostatic effect (tetracyclines, sulfonamides, erythromycin and chloramphenicol) and a synergist of cephalosporins, aminoglycosides, rifampicin, vancomycin, cycloserine.

With simultaneous use with glucosamines, aminoglycosides, laxatives and antacids, slow absorption is observed, and when taken along with ascorbic acid, metabolism increases.

It reduces the effectiveness of oral contraceptives and drugs that form para-aminobenzoic acid in the process of metabolism.

Diuretics, NSAIDs, Probenecid, Allopurinol and other drugs that reduce tubular secretion, used in combination with Ampisid, increase the concentration of the antibacterial drug, prolong its half-life and increase the risk of toxicity.


  • Individual intolerance to the components of the drug;
  • Hypersensitivity to penicillin and other beta-lactam antibiotics;
  • Severe gastrointestinal disorders;
  • Acute lymphoblastoid leukemia;
  • Age up to 3 years;
  • Infectious mononucleosis;
  • Bronchial asthma;
  • Hay fever;
  • Viral infections;
  • Allergic diathesis.

special instructions

Treatment with penicillin preparations sometimes leads to the development of quite serious conditions, including anaphylactic shock and death. Therefore, in the event of even minor allergic reactions, the drug should be noted and the patient should be given appropriate treatment.

Patients with septic complications may form a bacteriolysis reaction.

During treatment, the function of the liver, kidney and hematopoietic system should be constantly monitored. Also in this situation, excessive growth of microorganisms insensitive to Ampisid (including fungal microflora) can be observed.


With an overdose of the antibiotic, dizziness, fatigue, headaches, drowsiness, general malaise, sleep disturbance, emotional lability, depression, increased anxiety are observed. At very high concentrations of the drug in the cerebrospinal fluid disrupts the normal functioning of the central nervous system, up to the development of seizures.

Terms of implementation

Ampiside, powder for suspension, refers to prescription drugs.

Storage conditions

Store in a dark, protected from light and moisture, out of the reach of children, at a temperature not exceeding 25 C. After preparation, store in the refrigerator for no more than 14 days.

Shelf life

The drug is usable for 2 years from the date of issue. Use of the product after the expiration date indicated on the package is prohibited.


Preparations from the same pharmacological group and a similar mechanism of action: Amoxicillin , Amoxiclav, Augmentin, Flemoklav, Oskampitsin, Medoklav, Sulbacin.

Ampiside Price Powder for Suspension

Ampisid powder for the preparation of a suspension for oral administration, a bottle of dark glass 40 ml with a dosing spoon - from 166 rubles.

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