The Ammiside suspension for children: instruction manual, price, reviews, analogs
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Ammiside suspension for children: instruction manual

Ammiside suspension for children

ATX code: J01CR01.

Form release: powder for the preparation of suspension.

Dosage form: white powder, white homogeneous suspension.

Clinico-pharmacological group: Antibacterial preparation of a broad spectrum of action of a group of penicillins with an inhibitor of beta-lactamases.

Pharmacotherapeutic group: double ester of ampicillin and sulbactam, a derivative of 6-aminopenicillinic acid.

Packing: a bottle of yellow glass with a risk, ukuporennaya aluminum lid, measuring spoon, cardboard box.


Active ingredient: sultamycillin tosylate dihydrate.

Auxiliary components: acetic anhydride, xanthan gum, sucrose, sodium dihydrogen phosphate, sodium carmellose, giprolose, flavor.


The drug has a bactericidal effect on Gram-positive and Gram-negative aerobic and anaerobic bacteria, inhibiting the biosynthesis of peptoglycans of the bacterial cell membrane. The double ester of ampicillin readily disintegrates under the influence of beta-lactamases, and sulbactam irreversibly inhibits a group of bacterial enzymes aimed at combating antibiotics of the penicillin series.

It is active against Gram-positive and Gram-negative bacteria, (Staphylococcus aureus and Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus faecalis and other streptococci, Haemophilus influenzae and Haemophilus parainfluenza, Branhamella catarrhalis, Escherichia coli, Klebsiella spp., Proteus spp. (Indolpositive and indolotric), Morganella morganii, Citrobacter spp., and Enterobacter spp., Neisseria meningitidis, Neisseria gonorrhoeae, and anaerobic bacteria.


Ammiside in the digestive tract breaks down into ampicillin and sulbactam (1: 1). The time of food intake does not have a significant effect on the bioavailability of the drug.

The maximum concentration in plasma reaches in 1-2 hours. The binding of an active substance with plasma proteins is 28% (ampicillin) and 38% (sulbactam). The drug is distributed to all tissues and body fluids. Quickly wilts into the lung tissue, the fluid of the middle ear, bronchial secretion, urine and bile. In high concentrations, it accumulates in the liver. Concentration in the bile is 2 times higher than the concentration in the plasma.

The half-life is 45 minutes and 60 minutes, respectively. In patients with impaired renal, advanced and newborn children, T1 / 2 is more prolonged. About 55-75% of Ammiside is excreted by the kidneys, a small part - by the intestine, along with feces. With inflammation of the soft medulla the drug is able to penetrate the blood-brain barrier, it is removed during hemodialysis. Penetrates into the placenta and is excreted in breast milk.

Indications for use

  • Infections of the upper and lower respiratory tract;
  • Gynecological diseases of bacterial etiology;
  • Infections of skin and soft tissues;
  • Intra-abdominal infections;
  • Inflammation of bone tissue and articular joints;
  • Urinary system infections;
  • Gonorrhea ;
  • Postoperative prophylaxis after cesarean section and abortion;
  • Bacterial septicemia.


The daily dose for adults and children over 5 years old, with a body weight of more than 30 kg is prescribed taking into account the age and severity of the disease (375-750 mg / day, divided by 2 times).

Children under 5 years with a body weight of less than 30 kg per day are assigned 50 mg per 1 kg of body divided into 2 doses.

The average duration of treatment is 5-14 days. After the disappearance of clinical signs of the disease drug should be used for 2 more days.

Method of preparing the suspension

The powder is dissolved with boiled water, cooled to room temperature. The volume of the liquid is brought to the label in the vial, shaking periodically. In conclusion, to completely dissolve the liquid, let stand for 5 minutes. Before each use, the vial is shaken carefully. After breeding, the antibacterial mixture is stored in the refrigerator for no more than two weeks. Freezing is not allowed.

Side effects

From the skin : itching, hives , erythema multiforme.

On the part of the digestive tract : nausea, diarrhea, glossitis, enterocolitis, pseudomembranous colitis (rare enough).

From the hematopoietic system : a decrease in hemoglobin, lymphocytosis, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytosis (from ≥0.1% to <1%).

From the side of the urinary system : interstitial nephrosis (from ≥0.1% to <1%).

Other : with prolonged use of the drug - candidiasis of the vagina, in patients with reduced resistance of the body, the development of superinfection is possible.

Drug Interactions

The drug enhances the effect of anticoagulants (changes the aggregation of platelets and hemocoagulation indicators).

Ammiside is an antagonist of drugs that have a bacteriostatic effect (tetracyclines, sulfonamides, erythromycin and chloramphenicol) and synergists of cephalosporins, aminoglycosides, rifampicin, vancomycin, cycloserine.

With simultaneous use with glucosamines, aminoglycosides, laxatives and antacids, slow absorption is observed, when taken together with ascorbic acid, the metabolism rises.

Reduces the effectiveness of oral contraceptives and drugs, forming in the process of metabolism para-aminobenzoic acid.

Diuretics, NSAIDs, Probenecid, Allopurinol and other drugs that reduce tubular secretion, used in conjunction with Ammiside, increase the concentration of antibacterial drugs, prolong the half-life of the antibiotic and increase the risk of toxicity.


  • Individual intolerance to the components of the drug;
  • Hypersensitivity to penicillin and other beta-lactam antibiotics;
  • Severe disorders of the gastrointestinal tract;
  • Acute lymphoblastosis leukemia;
  • Age to 3 years;
  • Infectious mononucleosis;
  • Bronchial asthma;
  • Hay fever;
  • Viral infections;
  • Allergic diathesis.

special instructions

Treatment with drugs of the penicillin group sometimes leads to the development of sufficiently serious conditions, up to anaphylactic shock and death. Therefore, if even minor allergic reactions occur, the drug should be noted and the patient should be treated accordingly.

In patients with septic complications, a bacteriolysis reaction may be formed.

In the course of treatment, the function of the liver, kidneys and hematopoietic system should be constantly monitored. Also in this situation, there may be excess growth of microorganisms insensitive to Ambiside (including fungal microflora).


When the antibiotic is overdosed, dizziness, fatigue, headaches, drowsiness, general malaise, sleep disturbance, emotional lability, a depressed state, increased anxiety are observed. At very high concentrations of the drug in the cerebrospinal fluid, the normal functioning of the central nervous system is disrupted, up to the development of seizures.

Terms of implementation

Ammiside, a powder for the preparation of a suspension, refers to prescription drugs.

Storage conditions

Store in a dark place, protected from light and moisture, out of reach of children, at a temperature not exceeding 25 ° C. After cooking, store in the refrigerator for no more than 14 days.

Shelf life

The drug is suitable for use within 2 years from the date of manufacture. Do not use the product beyond the expiry date printed on the package.


Preparations from one pharmacological group and a similar mechanism of action: Amoxicillin , Amoxiclav, Augmentin, Flemoclav, Oscampicin, Medoklav, Sulbacin.

Price for Ammiside powder for suspension preparation

Ammiside powder for the preparation of a suspension for oral administration, a bottle of dark glass 40 ml with a dosage spoon - from 166 rubles.

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