Go Amoxicillin: instructions for use, price, reviews, analogs of tablets 500 mg Amoxicillin
medicine online


Amoxicillin instructions for use

Amoxicillin instructions for use

ATX Code: J01CA04.

Form release: coated tablets.

Dosage form: oval or oblong biconvex tablets with notches on both sides, from white to slightly yellowish.

Clinico-pharmacological group: A broad-spectrum antibacterial drug of the penicillin group.

Pharmacotherapeutic group: 4-hydroxyl analogue of ampicillin, semi-synthetic penicillin.


Active ingredient: Amoxicillin trihydrate.

Excipients: sodium carboxymethyl starch, polyvidone, magnesium stearate, talc, titanium dioxide, hypromellose.


Penicillin semisynthetic drug. The mechanism of action of this drug is based on its ability to specifically inhibit peptoglycans (bacterial cell membrane enzymes), which leads to cell death and dissolution.

Amoxicillin is active against:

Gram-positive aerobic bacteria - Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp., Listeria monocytogenes, Enterococcus faecalis, Corynebacterium spp. (except Corynebacterium jeikeium), Bacillus anthracis.

Gram-negative aerobic bacteria - Escherichia coli, Helicobacter pylori, Borrelia sp., Salmonella spp., Shigella spp., Campylobacter, Haemophilus spp., Proteus mirabilis, Leptospira spp., Neisseria spp.

Others - Chlamydia spp., Clostridium spp., Peptostreptococcus spp., Bacteroides melaninogenicus, Fusobacterium spp.


Amoxicillin is not destroyed by gastric juice and is completely adsorbed from the digestive tract. Maximum concentration in plasma reaches in 1-2 hours. When doubling the dose of its concentration also increases by 2 times. Total absorption does not depend on the presence of food in the stomach.

The binding of the active substance with plasma proteins is 20%. The drug is distributed to all tissues and body fluids. Quickly droops into the lung tissue, middle ear fluid, bronchial secretions, urine and bile. In high concentrations accumulates in the liver.

The half-life is 1-1.5 hours. In elderly patients and newborns, T1 / 2 is longer. With renal failure - up to 20 hours. About 60% of Amoxicillin is excreted by the kidneys, a small part - by the intestines, along with feces. When inflammation of the pia mater, the drug in small quantities is able to penetrate the blood-brain barrier, is removed during hemodialysis. It penetrates into the placenta and is excreted in breast milk.

Indications for use

  • Bacterial diarrhea, dysentery and other intestinal pathologies of infectious origin;
  • Otitis media and external otitis media of unspecified etiology;
  • Acute and subacute endocarditis;
  • Acute respiratory infections;
  • Sinusitis (acute form);
  • Acute pharyngitis of unspecified etiology;
  • Chronic bronchitis ;
  • Pneumonia;
  • Cystitis ;
  • Infections of urogenital organs without specified localization.


Dosage regimen is purely individual. The single dose for adults and children over 10 years old, with a body weight exceeding 40 kg, is 250-500 mg. In severe forms of the disease - up to 1 gram.

For children up to 2 years old, a single daily dose is 20 mg / kg.

Children from 5 to 10 years old - 125 mg.

The interval between doses of the drug - 8 hours. In patients with impaired renal function, the interval is increased to 12-24 hours.

Side effects

On the part of the skin : urticaria , erythematous rash, rhinitis, conjunctivitis , angioedema , photosensitivity, anaphylactic shock, malignant exudative erythema, Lyell's syndrome (very rare).

With prolonged use of the drug depressive state, dizziness, loss of coordination of movements, confusion, peripheral nephropathy.

Since the cardiovascular system : rapid heartbeat, phlebitis, lowering blood pressure, prolongation of the QT interval.

On the part of the circulatory and lymphatic systems : leukopenia, thrombocytopenia, eosinophilia, neutropenia. Very rarely, hemolytic anemia, pancytopenia, thrombocytopenic purpura.

On the part of the digestive tract : nausea, abnormal stool, changes in taste, glossitis, stomatitis, an increase in liver enzymes, dyspepsia, hepatitis, epigastric pain. Very rarely diarrhea with blood impurities, acute liver failure, pseudomembranous colitis.

On the part of the respiratory system : dyspnea, bronchospasm, allergic inflammatory processes in the lungs.

On the part of the excretory system : interstitial nephritis.

Nervous system disorders : headache, drowsiness, nervousness, dizziness, increased anxiety, peripheral neuropathy, behavioral changes, visual and olfactory disturbances, disturbances of tactile sensitivity, hallucinations.

On the part of the musculoskeletal system : myalgia, arthralgia, muscular weakness, tendonitis, tendon rupture (very rarely), rhabdomyolysis (destruction of muscle cells).

Others : vaginal candidiasis, febrile state, difficulty breathing, in patients with low resistance of the organism, the development of superinfection is possible.

Drug interactions

With simultaneous use of Amoxicillin with glucosamines, aminoglycosides, laxatives and antacids, slow absorption is observed, and when taken together with ascorbic acid, metabolism increases.

Drugs that block tubular secretion, cause an increase in Amoxicillin, while the use of Methotrexate increases the toxicity of the latter.

When used concurrently with metronidazole, nausea, vomiting, diarrhea, and epigastric pain often develop.

In a complex with clavulanic acid, the development of cholestatic jaundice, hepatitis, and multiforme erythema is possible.

It is strongly contraindicated for simultaneous use with disulfiram. Special care should be taken when using Amoxicillin and anticoagulants at the same time (this may cause prolongation of prothrombin time.

Interaction with Probenecid increases the serum concentration of the antibiotic and reduces its excretion from the body. Amoxicillin, like other antibacterial drugs, reduces the effectiveness of oral contraceptives.


  • Hypersensitivity to the drug;
  • Hypersensitivity to penicillin and other beta-lactam antibiotics;
  • Severe digestive disorders;
  • Acute lymphoblastoid leukemia;
  • Age up to 3 years;
  • Infectious mononucleosis;
  • Bronchial asthma;
  • Hay fever;
  • Viral infections;
  • Allergic diathesis.

special instructions

Amoxicillin with extreme caution should be used with a tendency to allergic reactions. Persons younger than 18 years and patients suffering from liver pathologies are not recommended to use the drug in combination with Metronidazole.

In case of impaired renal function, the dose of the drug should be reduced, and the intervals between doses increased. In the process of treatment it is necessary to constantly monitor the work of the liver, kidneys and blood-forming organs. To reduce the risk of developing complications of the digestive tract (nausea, vomiting, diarrhea, flatulence) Amoxicillin is recommended to be taken with meals. Data on the negative effects of drugs on the ability to manage vehicles is not available.

Terms of implementation

Amoxicillin, tablets, refers to prescription drugs.

Storage conditions

Store in a dark, protected from light and moisture, out of the reach of children, at a temperature not exceeding 25 C.

Shelf life

The drug is usable for 3 years from the date of issue. Use of the product after the expiration date indicated on the package is prohibited.

Amoxicillin analogues

  • Amosin pills
  • Flemoxine tablets
  • Ospamox Tablets
  • Ranoxyl tablets

Amoxicillin tablet prices

Amoxicillin tablets 500 mg, 20 pcs. - from 58 rubles.

Rate Amoxicillin on a 5-point scale:
1 звезда2 звезды3 звезды4 звезды5 звезд (votes: 3 , average rating 4.67 out of 5)

Reviews of the drug Amoxicillin:

  • | Olga | November 20, 2015

    The antibiotic is good, but I have a headache and weakness after it. Does anyone have a similar experience?

  • | Inna | November 20, 2015

    Finished the course of Amoxicillin. The head did not hurt, there was no weakness. But now the third day I can not go in large. Sorry for the details. How to quickly recover a chair?

Leave your feedback

Patrick Galloway: Also explain how meds can shut down your natural body functions that were trying to or were doing what the meds now do ...because your body immune system adjusts to the influx of medication and stops producing your own antibodies....tel people that most meds should be taken only when needed ...not neccessarily on a regular schedule...but used to boost your natural function

Patrick Galloway: Do a video on vapor to remove or kill unwanted cells...like in prostate cancer and swelling of the prostate and could probably be modified to treat and cure other cancers 😊