The Amoxicillin: instructions for use, price, feedback, tablet analogues 500 mg Amoxicillin
medicine online


Amoxicillin instructions for use

Amoxicillin instructions for use

ATX code: J01CA04.

Product: coated tablets.

Dosage form: oval or oblong biconvex tablets with notches on both sides, from white to slightly yellowish.

Clinico-pharmacological group: Antibacterial preparation of a broad spectrum of action of a group of penicillins.

Pharmacotherapeutic group: 4-hydroxyl analogue of ampicillin, penicillin semisynthetic.


Actively active substance: amoxicillin trihydrate.

Excipients: sodium carboxymethyl starch, polyvidone, magnesium stearate, talc, titanium dioxide, hypromellose.


Semisynthetic drug from the penicillin group. The mechanism of action of this drug is based on its ability to specifically inhibit peptoglycans (enzymes of bacterial cell membranes), which leads to death and dissolution of the cell.

Amoxicillin is active against:

Gram-positive aerobic bacteria - Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp., Listeria monocytogenes, Enterococcus faecalis, Corynebacterium spp. (except Corynebacterium jeikeium), Bacillus anthracis.

Gram-negative aerobic bacteria - Escherichia coli, Helicobacter pylori, Borrelia sp., Salmonella spp., Shigella spp., Campylobacter, Haemophilus spp., Proteus mirabilis, Leptospira spp., Neisseria spp.

Others include Chlamydia spp., Clostridium spp., Peptostreptococcus spp., Bacteroides melaninogenicus, Fusobacterium spp.


Amoxicillin does not collapse under the influence of gastric juice and is completely adsorbed from the digestive tract. The maximum concentration in plasma reaches in 1-2 hours. When the dose is doubled, its concentration also increases by a factor of 2. Total absorption does not depend on the presence of food in the stomach.

The binding of an active substance with plasma proteins is 20%. The drug is distributed to all tissues and body fluids. Quickly wilts into the lung tissue, the fluid of the middle ear, bronchial secretion, urine and bile. In high concentrations, it accumulates in the liver.

The half-life is 1-1.5 hours. In patients of advanced years and newborns, T1 / 2 is more prolonged. With renal failure - up to 20 hours. About 60% of Amoxicillin is excreted by the kidneys, a small part - by the intestine, along with the feces. With inflammation of the mild cerebral membrane, the preparation in small amounts is able to penetrate the blood-brain barrier, it is removed during hemodialysis. Penetrates into the placenta and is excreted in breast milk.

Indications for use

  • Bacterial diarrhea, dysentery and other intestinal pathologies of infectious origin;
  • Middle and outer otitis, unspecified etiology;
  • Acute and subacute endocarditis;
  • Acute respiratory infections;
  • Sinusitis (acute form);
  • Acute pharyngitis, unspecified etiology;
  • Chronic bronchitis ;
  • Pneumonia;
  • Cystitis ;
  • Infections of urogenital organs without specified localization.


The dosage regimen is strictly individual. The single dose for adults and children over 10 years old, with a body weight exceeding 40 kg, is 250-500 mg. In severe forms of the disease - up to 1 gram.

Children up to 2 years of a single daily dose of 20 mg / kg.

Children from 5 to 10 years - 125 mg.

The interval between doses of the drug is 8 hours. In patients with impaired renal function, the interval is increased to 12-24 hours.

Side effects

On the part of the skin : urticaria , erythematous rashes, rhinitis, conjunctivitis , Quincke's edema , photosensitivity, anaphylactic shock, malignant exudative erythema, Lyell's syndrome (very rarely).

With prolonged use of the drug, a depressive state, dizziness, movement coordination disorder, confusion, peripheral nephropathy.

From the cardiovascular system : heart palpitations, phlebitis, lowering of arterial pressure, prolongation of the QT interval.

From the blood and lymphatic system : leukopenia, thrombocytopenia, eosinophilia, neutropenia. Very rarely hemolytic anemia, pancytopenia, thrombocytopenic purpura.

On the part of the digestive tract : nausea, stool disorders, taste changes, glossitis, stomatitis, an increase in liver enzymes, dyspeptic disorders, hepatitis, epigastric pain. Very rarely diarrhea with blood impurities, acute liver failure, pseudomembranous colitis.

From the respiratory system : dyspnoea, bronchospasm, allergic inflammatory processes in the lungs.

On the part of excretory system : interstitial nephritis.

From the side of the nervous system : headache, drowsiness, nervousness, dizziness, increased anxiety, peripheral neuropathy, behavioral changes, visual and olfactory disorders, tactile sensitivity disorders, hallucinations.

From the musculoskeletal system : myalgia, arthralgia, muscle weakness, tendonitis, tendon rupture (very rarely), rhabdomyolysis (destruction of muscle cells).

Other : candidiasis of the vagina, febrile condition, shortness of breath, in patients with reduced resistance, the development of superinfections is possible.

Drug Interactions

With the simultaneous use of Amoxicillin with glucosamines, aminoglycosides, laxatives and antacids, slow absorption is observed, when taken together with ascorbic acid, the metabolism rises.

Drugs that block tubular secretion, cause an increase in Amoxicillin, while using Methotrexate increases the toxicity of the latter.

When used concomitantly with Metronidazole, nausea, vomiting, diarrhea, and pain in the epigastric region often develop.

In combination with clavulanic acid, cholestatic jaundice, hepatitis, and erythema multiforme can develop.

Categorically contraindicated simultaneous use with disulfiram. Care should be taken with simultaneous use of Amoxicillin and anticoagulants (this may cause prolongation of prothrombin time.

Interaction with Probenecid increases the serum concentration of the antibiotic and reduces its excretion from the body. Amoxicillin, like other antibacterial drugs, reduces the effectiveness of oral contraceptives.


  • Hypersensitivity to the components of the drug;
  • Hypersensitivity to penicillin and other beta-lactam antibiotics;
  • Severe digestive disorders;
  • Acute lymphoblastosis leukemia;
  • Age to 3 years;
  • Infectious mononucleosis;
  • Bronchial asthma;
  • Hay fever;
  • Viral infections;
  • Allergic diathesis.

special instructions

Amoxicillin with extreme caution should be used with a tendency to allergic reactions. Persons under the age of 18 and patients suffering from hepatic pathologies are advised not to use the drug in combination with Metronidazole.

If the renal function is impaired, the dose of the drug should be reduced, and the intervals between doses are increased. In the process of treatment, it is necessary to constantly monitor the functioning of the liver, kidneys and hematopoiesis. To reduce the risk of complications from the digestive tract (nausea, vomiting, diarrhea, flatulence) Amoxicillin is recommended when taking food. Data on the negative effects of drugs on the ability to drive vehicles is not available.

Terms of implementation

Amoxicillin, tablets, refers to prescription drugs.

Storage conditions

Store in a dark place, protected from light and moisture, out of reach of children, at a temperature not exceeding 25 ° C.

Shelf life

The drug is suitable for use within 3 years from the date of manufacture. Do not use the product beyond the expiry date printed on the package.

Amoxicillin analogues

  • Amosin tablets
  • Flemoxin tablets
  • Ospamox tablets
  • Ranoxil tablets

Prices for tablets Amoxicillin

Amoxicillin tablets 500 mg, 20 pcs. - from 58 rubles.

Estimate Amoxicillin on a 5-point scale:
1 звезда2 звезды3 звезды4 звезды5 звезд (votes: 3 , average rating 4.67 of 5)

Reviews about the drug Amoxicillin:

  • | Olga | 20 November 2015

    The antibiotic is good, but after me it hurts my head and weakness. Does anyone have a similar experience?

  • | Inna | 20 November 2015

    I finished the course of Amoxicillin. My head was not sick, there was no weakness. But already the third day I can not go to great length. Sorry, for details. How quickly to restore a chair?

Leave your feedback