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Ambroxol syrup instruction manual

Ambroxol Syrup

Ambroxol Syrup is a representative of the pharmacological group of mucolytics and expectorants. It contains the active ingredient Ambroxol hydrochloride, which reduces the viscosity of sputum and facilitates its excretion from the respiratory tract.

Release form and composition

Syrup is available in bottles of 100 ml. The bottle is made of dark glass to prevent exposure of light to the active substance. The carton pack also contains a measuring spoon (volume 5 ml). Ambroxol contains 15 mg of ambroxol hydrochloride in 5 ml of syrup. Also in 1 ml of the drug contains such a number of excipients:

  • Benzoic acid - 2 mg.
  • Giettiloza (hydroxyethyl cellulose) - 1 mg.
  • Glycerol (85%) - 127 mg.
  • Sorbitol (75%) - 250 mg.
  • Raspberry flavoring - 2.5 mg.
  • Purified water - up to 1 ml.

Existence of a measuring spoon provides convenience of dispensing and reception of syrup.

pharmachologic effect

The main active ingredient of syrup Ambroxol belongs to the pharmacological group of expectorant drugs and mucolytics. It has several therapeutic effects, which include:

  • Strengthening the motor activity of cilia lining the mucous membrane of the respiratory tract (mucociliary clearance), which accelerates the excretion of sputum and various pathogenic agents (bacteria, viruses, chemical compounds, allergens).
  • Stimulation of the production of mucosal cells of the respiratory organs by enzymes that catalyze the reaction of destruction of intramolecular bonds of mucopolysaccharides of sputum, thereby reducing its viscosity.
  • Increased activity of serous cells that produce liquid sputum.

These therapeutic effects of ambroxol hydrochloride facilitate the protective function of the respiratory mucosa. With improved sputum excretion, the cough becomes wet, then its intensity gradually decreases. After ingestion, the active substance is absorbed into the blood from the lumen of the small intestine. Therapeutic concentration is reached within 20 minutes after taking the syrup. The necessary concentration in the mucous membrane of the respiratory tract lasts for 6-12 hours. Then, ambroxol hydrochloride is processed by the liver cells to form its decay products, which are excreted by the kidneys in the urine. The half-life of the active substance (the time during which half of the entire dose of the drug is removed) is about 10 hours. Ambroxol penetrates into breast milk during lactation and into the fetus through the placenta during pregnancy.

Indications for use

The use of Ambroxol syrup is indicated for the pathology of the respiratory organs, in which viscous, thick mucus accumulates in the lumen of the bronchi. These diseases include:

  • Infectious etiology bronchitis caused by bacteria and viruses.
  • Tracheitis - inflammation of the trachea of ​​various etiologies.
  • Pneumonia is an inflammation of the lungs, which most often develops as a result of an infectious process.
  • Bronchiectasis - the formation of bronchial enlargements (bronchiectasis), in which the inflammatory process develops and sputum accumulates.
  • Bronchial asthma and atopic bronchitis - an allergic inflammation of the bronchi, which produces a thick vitreous sputum.
  • Obstructive bronchitis - chronic inflammation, accompanied by a narrowing (spasm) of the lumen of the bronchi and the accumulation of viscous sputum in them.
  • Cystic fibrosis is a genetic pathology with impaired sputum production processes, its quantity is small and it has a high viscosity.

Due to its pharmacological properties, Ambroxol Syrup is a pathogenetic component in the treatment of these diseases.

Contraindications

Ambroxol syrup should not be taken in such cases:

  • Individual intolerance to ambroxol hydrochloride or other auxiliary components of the drug.
  • Early gestational age (I trimester) - the penetration of ambroxol hydrochloride into the fetus through the placenta does not exclude its negative effect.
  • Congenital or acquired enzyme deficiencies in the digestive system that catalyze the breakdown of fructose.
  • Ulcerative pathology of the mucous membrane of the duodenum or stomach - Ambroxol hydrochloride can accelerate cell damage by reducing the protective properties of the mucous membrane of these organs.

The use of Ambroxol syrup in late periods (II and III trimester) of pregnancy and during breastfeeding is possible, but only for medical reasons, which are determined by the doctor. This necessarily analyzes the positive therapeutic effects on the mother's body and the potential risk of adverse effects on the fetus or infant.


Dosing and Administration Ambroxol syrup for children

Ambroxol syrup is taken orally to a certain extent, which can be controlled with a measuring spoon. The dosage of the drug depends on the severity of the disease and the age of the patient. Recommended age dosage of the drug for children:

  • The child’s age is from 2 to 6 years old - ¼ part of a measuring spoon (1.25 ml of syrup) 2-3 times a day (7.5-11.25 mg of ambroxol per day).
  • The child is 6 to 12 years old - ½ measuring spoons (2.5 ml of syrup) 3 times a day (daily dose of 22.5 mg of ambroxol hydrochloride).
  • Age over 12 years - 1 scoop (5 ml) 2-3 times a day (30-45 mg of ambroxol hydrochloride per day).

The first 2-3 days from the onset of the disease it is recommended to take the drug 3 times a day, then switch to a maintenance age dose with its intake 2 times a day. It is desirable to drink syrup with plenty of water, which will improve the dilution of sputum in a child and its subsequent elimination.

Attention!

For children under 2 years of age, the doctor decides on the use of Ambroxol syrup individually. He may prescribe the drug in a dosage of лож measuring spoon 1-2 times a day, depending on the severity of the disease.
It is not recommended to give a drug to a child under 2 years old on their own.

Side effects

In general, Ambroxol Syrup is well tolerated. In rare cases, these side effects may develop:

  • Allergic reactions in the form of a rash on the skin, its itching, urticaria (a characteristic rash in appearance resembling a nettle burn), angioedema of the skin and subcutaneous tissue ( Quincke edema ). In severe cases of severe allergic reactions, anaphylactic shock can develop - a progressive reduction in blood pressure and multiple organ failure.
  • Dyspeptic syndrome - changes in the digestive tract, which are manifested by nausea, vomiting and upset stool.
  • Increased excitability of the nervous system and changes in the reaction of the sense organs.
  • Dryness of the mucous membranes of the oral cavity, nasal cavity, pharynx, larynx and trachea.

Extremely rare cases of development of pronounced skin changes, but their relationship with the reception of ambroxol hydrochloride could not be precisely determined. In the case of side effects, the drug should be stopped and seek medical help.

special instructions

Before using Ambroxol syrup, it is necessary to familiarize yourself with its instructions. There are a number of points worth paying attention to, these include:

  • The drug is taken after meals, because on an empty stomach it can have a negative effect on the gastrointestinal tract.
  • After receiving the required volume of syrup, it is necessary to drink it with plenty of water to improve the dilution of sputum.
  • The average duration of taking Ambroxol syrup is 4-5 days; if it is necessary to extend the course of treatment, it is necessary to consult a doctor.
  • Ambroxol syrup can be combined with almost all drugs of other pharmacological groups, with the exception of antitussives, which provoke stagnation of sputum in the respiratory tract.
  • The combined use of Ambroxol syrup and antibiotics, enhances the effectiveness of the latter by increasing their concentration in the respiratory tract.
  • With care, Ambroxol Syrup is used in the presence of concomitant pathology of the liver and kidneys - for its use it is desirable to conduct laboratory monitoring of the functional activity of these organs.
  • Ambroxol does not affect the reaction rate and concentration of attention, so it can be taken by persons whose activity is associated with increased attention and reaction rate (vehicle drivers, work at height).

Ambroxol syrup is an over-the-counter drug, so it is available over the counter in pharmacies. If you have questions or doubts about his admission, you should consult with your doctor.


Overdose

Ambroxol syrup has a wide dosage range. With a significant overdose, the reaction from the digestive (nausea, vomiting, diarrhea) and nervous (irritability) systems may develop. In the event of such symptoms, the drug is stopped, the gastric and intestinal lavages are performed. If necessary, connect detoxification therapy (intravenous drip adsorption funds).

Terms and conditions of storage

The drug can be stored no more than 2 years in a dark place inaccessible to children with air temperature not higher than 25 ° C.

Ambroxol Syrup Analogs

Similar drugs whose active ingredient is ambroxol hydrochloride include Ambrobene, Ambrohexal, Ambrolitin, Bronchoxol, Medox, Flavamed, Lasolvan.

Ambroxol syrup price

Ambroxol syrup, bottle 100 ml - from 81 rubles.

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