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Ambrohexal syrup instruction manual

Ambrohexal Syrup

AmbroGEXAL Syrup is a representative of the pharmacological group of drugs for mucolytics (expectorants). Its main therapeutic effects are provided by the main active ingredient, ambroxol hydrochloride. Due to it, the drug dilutes sputum, improves its rheological properties and facilitates elimination from the body.

Dosage form and composition

The drug is available in the form of syrup for oral administration in dark bottles, with a dispenser, a volume of 100 ml and 250 ml. The set includes a special measuring spoon. The main active ingredient is ambroxol hydrochloride, which is contained in an amount of 15 mg in 1 ml of syrup. Also included in the preparation are auxiliary substances (their concentration in 1 ml), which include:

  • Glycerol - 127.5 mg.
  • Benzoic acid - 2 mg.
  • Gietteloza - 1 mg.
  • Sorbitol (75% solution) - 250 mg.
  • Propylene glycol - 30 mg.
  • Apricot flavoring - 2.5 mg.
  • Levomenthol - 0.08 mg.
  • Purified water - up to 1 ml.

Bottles of 100 and 250 ml are made of dark glass, to prevent the destruction of the active substance under the influence of light. They are packed in cardboard packaging with instructions and measuring spoon. Measuring spoon and a different volume of the drug provide ease of use.

Pharmacological action of the drug

The active ingredient of ambrohexal syrup (ambroxol hydrochloride) belongs to the pharmacological group of mucolytics and expectorant drugs. This is due to several of its therapeutic effects, which include:

  • Reducing the viscosity of sputum, improving its rheological properties by stimulating the production of enzymes by the cells of the respiratory tract mucosa, which break down the intramolecular bonds of mucopolysaccharides (responsible for the viscosity) of sputum, diluting it.
  • Stimulation of the production of liquid sputum by serous cells of the mucous membrane of the bronchi, bronchioles and trachea.
  • Increased mucociliary clearance - activation of the motor activity of cilia, which by their movements contribute to the removal of sputum.

These main therapeutic effects of ambroxol are pathogenetic, they are aimed at the early removal of sputum and purification of the respiratory system from foreign agents (viruses, bacteria, chemicals, dust particles, allergens). AmbroGEXAL dosage form in the form of a syrup allows for the fastest absorption of the active substance into the blood, the therapeutic concentration of which is reached in 15-20 minutes. The duration of ambroxol in the body is about 8-10 hours, then it is processed in the liver to form intermediate metabolic products that are excreted by the kidneys with urine. The half-life (elimination from the body of half of the entire concentration of the drug) is 10-12 hours. Ambroxol is distributed in almost all tissues of the body with a predominant accumulation in the respiratory tract. It also penetrates into breast milk during lactation and through the placental barrier into the body of a growing fetus during pregnancy.

Indications for use

The use of AmbroGEAL syrup is indicated for various pathological conditions of the respiratory system organs, accompanied by a significant accumulation of thick, viscous sputum in the airways. These include:

  • Acute or chronic infectious bronchitis (inflammation of the bronchial mucosa) caused by viruses, bacteria.
  • Tracheitis - inflammation of the trachea, which can be triggered by various damaging factors or infection.
  • Bronchiectasis - a pathological expansion of the bronchi against the background of a chronic inflammatory process in them with the accumulation of a significant amount of thick sputum and the addition of a bacterial infection.
  • Chronic obstructive respiratory disease is a pathology that primarily affects the bronchi with the development of their spasm (constriction) and the accumulation of thick sputum. The most common cause of this pathology is smoking.
  • Pneumonia is an inflammation of the lungs of an infectious nature.
  • Bronchial asthma or atopic bronchitis is an inflammatory-allergic reaction of the bronchi in response to the ingestion of allergens. It is characterized by their spasm, the accumulation of sputum and the development of an attack of suffocation.
  • Cystic fibrosis is a systemic genetic disease in which the production of secretions of various glandular cells is disturbed in the body. In the organs of the respiratory system this is manifested by the synthesis of thick and viscous sputum.

These indications are primarily aimed at improving the protective function of the bronchi and lungs, which ambroxol stimulates.

Contraindications

AmbroGEXAL syrup due to the presence in it of the main active ingredient Ambroxol hydrochloride is contraindicated for use in such cases:

  • Pregnancy in the first trimester - the teratogenic effect of ambroxol is not proven, but due to its penetration through the placenta, the negative effect on the body of the growing fetus is not excluded.
  • Individual intolerance to ambroxol or other excipients, which may be manifested by the development of various negative reactions.
  • Hereditary fructose intolerance - the taking of Ambrohexal syrup in this case can provoke pronounced intestinal disorders.
  • Peptic ulcer of the stomach or duodenum - Ambroxol reduces the protective properties of the mucous membrane of these organs and can provoke an exacerbation of the pathology and an increase in the defect of the walls.

Pregnancy in the later stages of its course (II and III trimester) and breastfeeding are relative contraindications. In these cases, it is possible to use the drug only as prescribed by a doctor, who determines the ratio of benefits to the mother and the potential danger to the fetus or infant.


Dosing and Administration

AmbroGEXAL syrup is taken orally, the dosing of the drug is carried out using a measuring spoon. The dosage regimen is determined by the severity of the pathology, the severity of dry cough, which provokes a viscous sputum and the patient's age. Recommended age dosages of the drug are as follows:

  • Children aged 2 to 6 years - ¼ measuring spoon (volume 1.25 ml of syrup) 3 times a day (ambroxol daily dose of about 15 mg).
  • Children from 6 to 12 years old - ½ measuring spoons (2.5 ml of syrup) 3 times a day (22.5 mg of ambroxol). For maintenance therapy, the dose is reduced to 2 times the dose - ½ scoop 2 times a day.
  • Children over 12 years old and adults - 1 measuring spoon (volume of syrup 5 ml) 3 times a day (the first 2-3 days), then the maintenance dose is 1 measuring spoon 2 times a day (30 mg of ambroxol per day).

Children under 2 years old may be prescribed the drug only under the supervision of the attending physician. The average dosage depends on the severity of the disease and is about ¼ measuring spoon 1-2 times a day. After taking AmbroGEXAL syrup, wash it down with plenty of liquid.

Side effects

AmbroGEXAL syrup rarely leads to the development of side effects, however, such negative reactions of the body can occur:

  • Allergic reactions to the active or auxiliary substance of the drug - a rash on the skin, itching, urticaria (a rash on the background of puffiness, resembling a nettle burn), angioedema of the skin and subcutaneous tissue ( Quincke edema ). In rare cases, severe allergic reactions may develop in the form of anaphylactic shock (progressive reduction in systemic arterial pressure and loss of consciousness).
  • The reaction on the part of the digestive system - nausea, periodic vomiting, weakened stools until the development of diarrhea. To a greater extent, these manifestations can occur in people with reduced activity of enzymes catalyzing the breakdown of fructose.
  • Increased excitability of the nervous system.
  • Dryness of the mucous membranes of the mouth, pharynx, larynx and trachea.

There are cases of severe skin reactions. However, it was not possible to establish the exact relationship between their development and ambroxol intake. In case of occurrence of side effects, it is necessary to stop taking the drug and seek medical help. For the rapid elimination of ambroxol from the body and prevent its absorption from the stomach and intestines, gastric and intestinal lavage and intravenous drip detoxification therapy are used.

special instructions

Before you start taking the syrup Ambrohexal must be sure to read the instructions. There are several specific indications regarding its reception:

  • The drug must be taken after meals to reduce the negative effects on the stomach and duodenum.
  • After ingestion, it is advisable to drink the syrup with plenty of water - this will improve the secretion of liquid sputum and its subsequent excretion.
  • The course of treatment with this drug averages 4-5 days, with continued coughing or no effect, the question of extending the intake of syrup Ambrohexal is decided by the doctor.
  • AmbroGEXAL syrup can be combined with other drugs, with the exception of drugs that suppress cough. Ambroxol increases the concentration of antibiotics in the airways, which enhances the effect of their use.
  • In the case of a concomitant pathology of the liver or kidneys, the use of ambrohexal syrup is possible with extreme caution.
  • Ambroxol and drug excipients do not affect the level of concentration and the rate of human reactions.

Ambrogeksal syrup is freely available in pharmacies, to buy it, a doctor's prescription is not needed. In case of any doubts or questions, it is advisable to consult a doctor.


Overdose

Ambroxol has a wide range of dosages. With its significant excess may develop diarrhea, nausea, vomiting and excitation of the central nervous system.

Terms and conditions of storage

The expiration date of syrup Ambrobene, Lasolvan is 2 years from the moment of its release. Keep it in a dark cool place, at a temperature not higher than 25 ° C. Keep out of the reach of children.

Ambrogexal Syrup Analogs

The preparations that contain ambroxol hydrochloride as the main active ingredient are Bronchoxol, Medox, Flavamed, Ambrobene, Lasolvan.

Ambrogexal syrup price

Ambrohexal syrup, 100 ml bottle - from 101 rub.

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