The Ambroben tablets: instructions for use, price, testimonials, analogues of tablets Ambrobene
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Ambroben tablets instructions for use

Ambroben tablets

Ambrobene tablets are a medicine that belongs to the pharmacological group of expectorants and is used for various types of cough to improve the excretion of sputum. The main active substance of this drug is ambroxol.

Composition and dosage form

Ambrobene tablets are produced in blisters for 10 pieces, in one package contains 20 tablets (2 blisters). They are small in size, have a white color, biconvex round shape, on the one hand there is a dividing risk for a convenient fracture of the tablet in half. On the other hand, there is no dividing risk, and it is flat. Active active compound of tablets Ambrobene - ambroxol hydrochloride, which belongs to the pharmacological group of mucolytics (expectorants), its amount in 1 tablet is 30 mg. Also in the composition of the tablets are auxiliary substances, which include:

  • Lactose monohydrate is 169.46 mg.
  • Corn starch - 36.33 mg.
  • Magnesium stearate - 2.41 mg.
  • Colloidal silicon dioxide anhydrous - 1.8 mg.

Packing tablets in blisters for 10 pieces is convenient and makes it possible to purchase not all packaging (there are 20 tablets), but only half (1 blister).



Pharmacological action of the drug

Active substance Ambrobene in tablets Ambroxol belongs to the group of mucolytics or expectorants. This is due to its main effects, which include:

  • The secretolitic effect, ambroxol, stimulates the production of enzymes by the bronchial mucosa cells, which destroy the intramolecular bonds of the mucopolysaccharides of the sputum, which leads to its dilution and facilitated removal from the respiratory tract. Liquefaction is also achieved due to an increase in ambroxol activity of secretory cells (serous cells) producing more liquid sputum.
  • The secretory effect is the active substance of the Ambrobene tablets, which increases the motor activity of the cilia that line the surface of the bronchial mucosa and trachea, thereby improving the excretion of sputum (increased mucociliary clearance).

By improving the excretion of sputum, the expectorant effect of ambroxol is manifested, cough becomes productive (moist cough) and its intensity decreases. Also an important effect is the removal of infection or other pathological factors (dust, aggressive chemical compounds) from the respiratory tract along with phlegm. After taking the Ambrobene pill, its active substance achieves therapeutic (therapeutic) concentration in the body on average in 20-30 minutes. The metabolism of ambroxol is carried out in liver cells (hepatocytes), where up to 90% of the substance is processed. The metabolic products are excreted by the kidneys in the urine. The half-life (the time during which 50% of the active substance is excreted from the body) is on the average 8-12 hours. Accordingly, during this time, the therapeutic concentration of ambroxol remains in the body, necessary for the realization of its therapeutic effects. Ambroxol penetrates into breast milk during breastfeeding, in the fetal tissue through the placenta during pregnancy.

Indications for use

The main indication for the use of Ambrobene in tablets is the pathology of the respiratory tract, which is accompanied by inflammation of the mucosa, coughing and production of viscous sputum. Such diseases include:

  • Infectious bronchitis is an inflammatory process in the bronchial mucosa caused by various infectious agents (viruses, bacteria). Ambrobe has a good therapeutic effect in both acute and chronic bronchitis.
  • Bronchial asthma - a chronic allergic pathology, accompanied by coughing and shortness of breath, during which a large amount of thick sputum is synthesized.
  • Pneumonia is an inflammation of the lungs, which can be caused by various causes, primarily infection.
  • Tracheitis - inflammation of the walls and mucous membrane of the trachea.
  • Chronic obstructive bronchitis is a prolonged inflammation of the bronchi caused by various toxic compounds, primarily by smoking.
  • Bronchoectatic disease is a long-lasting pathology of the bronchi, in which, against the background of the inflammatory process, their extensions (protrusions) form in which thick sputum accumulates.
  • Cystic fibrosis is a hereditary pathology with a severe course. Its mechanism of development is accompanied by impaired sputum synthesis, which is accompanied by a significant increase in its viscosity.

Since ambroxol stimulates the excretion of sputum, when it is used, it is important not to carry out activities and do not use medications that depress cough, as this will lead to congestion in the bronchi.

Contraindications for use

There are several pathological and physiological conditions of the human body, in which the use of Ambrobene tablets is contraindicated:

  • Individual intolerance of any component of the drug - ambroxol or excipients, which manifests itself in the deterioration of the person's well-being after taking it.
  • The pathology of the mucosa of the stomach or duodenum, which is accompanied by the formation of its defect - peptic ulcer, erosive gastritis .
  • I trimester of pregnancy - ambroxol penetrates the placenta into the fetus, which can lead to disruption of its development.

With regard to the use of Ambrobene tablets in the 2nd and 3rd trimester of pregnancy, there is no precise data on its harmful effect on the growing fetus. Therefore, the doctor can prescribe the drug in case the expected benefit for a pregnant woman exceeds the potential risk for a growing fetus.


Dosage and route of administration

Ambrobe contains ambroxol in an amount of 30 mg in 1 tablet. When ingested, the active substance is absorbed into the blood from the small intestine and accumulates in the organs of the respiratory system, where it has a therapeutic effect. The dosage of the drug is selected depending on the severity of dry cough and the age of the person:

  • Children from 2 to 6 years old - 1/2 tablet 2 times a day (daily dose 30-45 mg).
  • Children older than 12 years and adults - the first 2-3 days from the onset of the disease 1 tablet 2-3 times a day (the total daily dose is 60-90 mg), then a maintenance dosage of 1 tablet 2 times a day (60 Mg per day). If necessary, the adult dosage can be increased to 2 tablets 2 times a day (daily dose of 120 mg ambroksola).

The tablet is taken whole, not liquid, washed down with a lot of water. To prevent the negative effects of ambroxol on the stomach and duodenal mucosa, the drug is recommended to use after eating. Also, the physician selects the dosage of the drug individually

Side effects

Ambrobene tablets when taken internally as a whole by the human body are well tolerated. Some people may develop side effects, which include:

  • Allergy to ambroxol or excipients - develops seldom (up to 1% of cases), is manifested by the appearance of rash and itching on the skin, urticaria (rash and swelling of the skin that resemble a nettle burn), angioedema, swelling of the skin and subcutaneous tissue of the face or genitals ). Very rarely develop anaphylactic shock (a severe allergic reaction with a progressive decrease in systemic blood pressure).
  • The violation of the general health of a person after taking the drug - the development of weakness, headache, fever.
  • Change in taste is a side effect of the functional activity of the nervous system.
  • Changes in the work of the digestive system, which are manifested by periodic bloating, the appearance of spasmodic pain in it, dry mucous membranes.

In case of any symptoms indicating the development of a side effect from taking the drug, its use should be stopped and seek medical help from a doctor.

special instructions

Before you start taking Ambrobene tablets, you should carefully read the instructions for their use. It is important to pay attention to certain features of their use:

  • Reception of the drug in the I trimester of pregnancy is excluded, since there is no reliable data on the absence of a teratogenic effect on the fetus. In the second and third trimester, admission is possible only after the appointment of a doctor who carefully weighs his expected benefit for the health of the mother and the potential danger to the fetus. The same applies to the use of Ambrobene tablets during breastfeeding (lactation).
  • Children under the age of 2 years of the drug is prescribed only by a doctor individually.
  • In parallel with the use of the drug, it is desirable to increase the flow of fluid into the body, which will improve the process of liquefaction of sputum.
  • Tablets Ambrobe is not desirable to be used in conjunction with drugs that depress the cough reflex, as this can provoke sputum congestion in the airways.
  • In the case of concomitant liver or kidney pathology, the drug is administered with caution, under constant laboratory monitoring of the functional activity of these organs.
  • On average, the course of treatment with Ambrobene tablets is about 4-5 days. In case of prolongation of the course, it is necessary to consult a doctor.
  • Combination of tablets Ambrobene and antibiotics increases the concentration of the latter in sputum, due to which the rate of destruction of bacterial infection in the airways increases.
  • Ambrogen does not affect the rate of human reactions, so its reception is allowed to people whose activities require increased attention and speed of reactions (work at height, driving).

Ambrobene tablets are an over-the-counter drug, they are released freely in pharmacies. If any questions arise regarding their admission, it is advisable to consult a doctor.

Overdose

In the case of a significant increase in the concentration of the drug in an organism exceeding the therapeutic dose, nausea, vomiting, diarrhea (diarrhea) of nervous excitement may develop. If such symptoms appear that indicate a possible overdose, seek medical attention.

Terms and conditions of storage

The shelf life of Ambrobene tablets is 5 years from the date of their manufacture. Keep preferably in a dark, cool place out of the reach of children. The temperature during storage should not exceed + 25 ° C.

Analogues

Preparations that contain ambroxol are Ambrosan, Lazolvan, Bronhoksol, Medox, Flavamed.

Prices for tablets Ambrobene

Ambroben tablets 30 mg, 20 pcs. - from 136 rubles.

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