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Ambrobene tablets instructions for use

Ambrobene pills

Ambrobene tablets are a medicament that belongs to the pharmacological group of expectorant drugs and is used for coughing of various origins to improve sputum excretion. The main active ingredient of this drug is Ambroxol.

Composition and dosage form

Ambrobene tablets are available in blisters of 10 pieces, in one pack contains 20 tablets (2 blisters). They are small in size, have a white color, a biconvex round shape, on the one hand there is a separation risk for a convenient breaking of the tablet in half. On the other hand, there is no separation risk, and it is flat. The active active compound of Ambrobene tablets is ambroxol hydrochloride, which belongs to the pharmacological group of mucolytics (expectorants), its amount per tablet is 30 mg. Also in the composition of the tablets include excipients, which include:

  • Lactose monohydrate - 169.46 mg.
  • Corn starch - 36.33 mg.
  • Magnesium stearate - 2.41 mg.
  • Anhydrous colloidal silicon dioxide - 1.8 mg.

Packing tablets in blisters of 10 pieces is convenient and makes it possible to purchase not all the packaging (there are 20 tablets), but only half (1 blister).

Pharmacological action of the drug

The active substance Ambrobene tablets Ambroxol belongs to the group of mucolytics or expectorant drugs. This is due to its main effects, which include:

  • The secretolytic effect - Ambroxol stimulates the production of enzymes by the bronchial mucous cells, which destroy the intramolecular bonds of mucopolysaccharides of sputum, which leads to its liquefaction and facilitation of excretion from the respiratory tract. The liquefaction is also achieved by ambroxol increasing the activity of secretory cells (serous cells) producing more liquid sputum.
  • Secretory effect - the active substance of Ambrobene tablets enhances the motor activity of the cilia lining the surface of the bronchial and tracheal mucous membranes, thereby improving sputum clearance (increased mucociliary clearance).

By improving sputum clearance, the expectorant effect of ambroxol is manifested, the cough becomes productive (wet cough) and its intensity decreases. Also important is the removal of infection or other pathological factors (dust, aggressive chemical compounds) from the respiratory tract along with sputum. After taking the tablet Ambrobene, its active ingredient reaches a therapeutic (therapeutic) concentration in the body on average after 20-30 minutes. Ambroxol is metabolized in the liver cells (hepatocytes), where up to 90% of the ingested substance is processed. Exchange products are excreted by the kidneys with urine. The half-life (the time during which 50% of the active substance is excreted from the body) is on average 8-12 hours. Accordingly, during this time, the therapeutic concentration of ambroxol remains in the body, which is necessary to realize its therapeutic effects. Ambroxol penetrates into breast milk during breastfeeding, in the fetal tissue through the placenta during pregnancy.

Indications for use

The main indication for the use of Ambrobene tablets is the pathology of the respiratory tract organs, which is accompanied by inflammation of the mucous membranes, cough and viscous sputum production. These diseases include:

  • Infectious bronchitis is an inflammatory process in the mucous membrane of the bronchi caused by various infectious agents (viruses, bacteria). Ambrobene has a good therapeutic effect in both acute and chronic bronchitis.
  • Bronchial asthma is a chronic allergic pathology, accompanied by coughing and shortness of breath, during which a large amount of thick sputum is synthesized.
  • Pneumonia is an inflammation of the lungs, which can be caused by various causes, primarily an infection.
  • Tracheitis - inflammation of the walls and mucous membrane of the trachea.
  • Chronic obstructive bronchitis is a long-term inflammation of the bronchi caused by various toxic compounds, primarily smoking.
  • Bronchiectasis - a long-lasting pathology of the bronchi, in which, against the background of the inflammatory process, their extensions (protrusions) are formed, in which thick sputum accumulates.
  • Cystic fibrosis is a hereditary pathology with a severe course. Its developmental mechanism is accompanied by a violation of the synthesis of sputum, which is accompanied by a significant increase in its viscosity.

Since Ambroxol stimulates sputum excretion, it is important not to take measures when using it and not to use cough depressant medicines, as this will lead to accumulation of sputum in the bronchi.

Contraindications

There are several pathological and physiological states of the human body in which the use of Ambrobene tablets is contraindicated:

  • Individual intolerance to any component of the drug - ambroxol or auxiliary substances, which is manifested by the deterioration of a person's well-being after his admission.
  • Pathology of the gastric or duodenal mucosa, which is accompanied by the formation of its defect - peptic ulcer, erosive gastritis .
  • I trimester of pregnancy - Ambroxol penetrates through the placenta into the body of the fetus, which can lead to violations of its development.

Regarding the use of Ambrobene tablets in the II and III trimester of pregnancy, there are no exact data on its harmful effects on the growing fetus. Therefore, the doctor may prescribe the drug if the expected benefit for a pregnant woman outweighs the potential risk to the growing fetus.


Dosage and method of use

Ambrobene contains Ambroxol in the amount of 30 mg in 1 tablet. When ingested, the active substance is absorbed into the blood from the small intestine and accumulates in the organs of the respiratory system, where it has a therapeutic effect. The dosage of the drug is selected depending on the severity of dry cough and age of a person:

  • Children from 2 to 6 years old - ½ tablet 2 times a day (daily dose of 30-45 mg).
  • Children older than 12 years and adults - the first 2-3 days from the onset of the disease, 1 tablet 2-3 times a day (total daily dose is 60-90 mg), then the maintenance dosage is applied 1 tablet 2 times a day (60 mg per day). If necessary, adults dosage can be increased to 2 tablets 2 times a day (daily dose of 120 mg of ambroxol).

The pill is taken whole without chewing, washed down with plenty of water. For the prevention of the negative effects of ambroxol on the gastric mucosa and duodenal ulcer, the drug is recommended after meals. Also, the doctor selects the dosage of the drug individually

Side effects

Ambrobene tablets, when taken orally, are generally well tolerated by the human body. Some people may develop side effects, which include:

  • Allergy to Ambroxol or excipients - rarely develops (up to 1% of cases), manifested by rash and itching on the skin, urticaria (rash and swelling of the skin, which resemble a nettle burn), angioedema of the skin or subcutaneous tissue of the face or genitals ( Quincke edema) ). Anaphylactic shock is extremely rare (severe allergic reaction with a progressive decrease in systemic arterial pressure).
  • Violation of the general well-being of a person after taking the drug - the development of weakness, headache, fever.
  • A change in taste is a side effect of the functional activity of the nervous system.
  • Changes in the digestive system, which are manifested by periodic abdominal distention, the appearance of spastic pain in it, dry mucous membranes.

In the event of any symptoms that indicate the development of a side effect from taking the drug, its use must be stopped and seek medical help.

special instructions

Before you start taking Ambrobene tablets, you must carefully read the instructions for their use. It is important to pay attention to certain features of their use:

  • Taking the drug in the first trimester of pregnancy is excluded, since there is no reliable data on the absence of a teratogenic effect on the fetus. In the II and III trimester, admission is possible only after a doctor is prescribed, who carefully weighs his expected benefits to the mother's health and the potential danger to the fetus. The same applies to the use of tablets Ambrobene during breastfeeding (lactation).
  • Children under the age of 2 years, the drug is prescribed only by a doctor on an individual basis.
  • In parallel with the use of the drug, it is desirable to increase the intake of fluid in the body, which will improve the process of sputum liquefaction.
  • Ambrobene tablets are not advisable to use in conjunction with drugs that inhibit the cough reflex, as this can cause stagnation of sputum in the airways.
  • In the case of concomitant pathology of the liver or kidneys, the drug is prescribed with caution, under constant laboratory control of the functional activity of these organs.
  • On average, the treatment with Ambrobene tablets is about 4-5 days. In case of prolongation of the course, it is necessary to consult a doctor.
  • The combined administration of Ambrobene tablets and antibiotics increases the concentration of the latter in the sputum, due to which the rate of destruction of a bacterial infection in the airways increases.
  • Ambrobene does not affect the speed of human reactions, therefore, its reception is allowed to people whose activities require increased attention and reaction speed (working at height, driving vehicles).

Ambrobene tablets are a non-prescription drug, pharmacies are available freely. In case of any questions regarding their admission, it is advisable to consult a doctor.


Overdose

In case of a significant increase in the concentration of the drug in the body, exceeding the therapeutic dose, nausea, vomiting, diarrhea (diarrhea) of nervous excitement may develop. If such symptoms occur, indicating a possible overdose, seek medical attention.

Terms and conditions of storage

The durability of Ambrobene tablets is 5 years from the date of their manufacture. Store preferably in a dark, cool place out of the reach of children. Storage temperature should not exceed + 25 ° C.

Analogs

Drugs that contain Ambroxol - Ambrosan, Lasolvan, Bronkhoksol, Medox, Flamed.

Prices pills Ambrobene

Ambrobene tablets 30 mg, 20 pcs. - from 136 rubles.

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