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Ambrobene solution for inhalation and oral administration instructions

Ambrobene solution for inhalation and oral administration

Inhalation solution Ambrobene belongs to the group of expectorant drugs. The active ingredient of this drug is Ambroxol, it dilutes sputum and improves its excretion from the lungs and bronchi when coughing of various etiologies.

Dosage form and composition

Ambrobene is made in the form of a solution for inhalation using special inhalers. This gives the opportunity for a good penetration of the active ingredient of the drug in the bronchi and lungs, where it has a therapeutic effect. The main active ingredient is Ambroxol, which belongs to the group of expectorant drugs (mucolytics). Its concentration in the solution is 7.5 mg / ml. Excipients and their concentration in 1 ml of solution:

  • Potassium Sorbate - 1 mg.
  • Hydrochloric acid - 0.6 mg.
  • Purified water - 991.9 mg.

In quantitative terms, there are 2 types of solution for inhalation Ambrobene - 40 and 100 ml. The vials are made of dark glass to prevent the destruction of the active substance under the action of light. The kit includes a measuring cup, which provides ease of dosing during its use.

Pharmacological action of the drug

The therapeutic effect of the solution for inhalation Ambrobene is provided by the main active ingredient - Ambroxol. It belongs to the pharmacological group of expectorant drugs (mucolytics) and has several effects, which include:

  • Secretive action is increased activity of the ciliated epithelium lining the respiratory tract mucosa (trachea, bronchi and alveoli). At the same time, the activity of the movements of the cilia lining the cell surface is enhanced, due to which sputum clearance is accelerated - improvement of mucociliary clearance.
  • Secretolytic action - Ambroxol stimulates the production of enzymes that destroy intramolecular bonds of mucopolysaccharides of sputum, due to which it becomes less dense. This facilitates its excretion from the respiratory tract. Ambroxol also enhances the activity of cells that produce more liquid sputum (serous cells).

All of these effects contribute to expectoration of sputum. Cough gradually becomes wet. Bacteria or other foreign agents are excreted with sputum, causing inflammation of the bronchial mucosa, bronchioles, and cough development. Ambroxol expectorant effect occurs within 10 minutes after inhalation of the solution and lasts about 8-10 hours. After ingestion, Ambroxol is metabolized in the liver to form metabolic products that are excreted by the kidneys. The half-life (elimination of 50% of the initial concentration of the drug in the body) is 6-12 hours. The active ingredient of the solution for inhalation passes into breast milk, which must be considered when breastfeeding.

Indications for use

The use of the solution for inhalation Ambrobene is shown to improve the excretion of sputum from the respiratory tract in diseases involving inflammatory process in them and the accumulation of viscous sputum. These include:

  • Acute or chronic infectious bronchitis is an inflammation of the bronchial mucous membrane caused by bacteria or viruses, which is accompanied by cough and secretion of viscous sputum.
  • Bronchiectasis - a chronic pathology of the bronchi with the formation of extensions in the bronchial tree, impaired respiratory function, accumulation of thick sputum and secondary infection.
  • Bronchial asthma is an allergic reaction of the respiratory organs, accompanied by a spasm (narrowing) of the bronchi and secretion of a large amount of viscous sputum.
  • Pneumonia is an inflammation of the lungs of infectious etiology.
  • Chronic obstructive bronchitis is a long-term inflammation of the bronchi caused by the toxic effects of various chemical compounds, in particular long-term smoking.
  • Tracheitis - inflammation of the tracheal mucosa of any etiology.
  • Cystic fibrosis is a severe hereditary pathology, in which the synthesis of sputum is impaired, it is produced very viscous and constantly accumulates in the airways.

The drug is undesirable to use in combination with antitussives, which reduce the severity of the cough reflex, as this can lead to stagnation of sputum in the lungs and bronchi.

Contraindications

Using the solution for inhalation Ambrobene is contraindicated in such cases:

  • Severe sensitivity to ambroxol or other auxiliary components of the drug.
  • Peptic ulcer with localization of ulcers in the stomach or duodenum.
  • Pregnancy in the early stages (I trimester).

During pregnancy in the II and III trimester, Ambrobene can be used only as prescribed by a physician, when the expected benefit outweighs the potential risk to the growing fetus.


Methods of use and dosage

Ambrobene can be used inside or in the form of inhalation using an inhaler. During inhalation, the active substance accumulates in the bronchi and bronchioles faster, which accordingly reduces the period of the beginning of the development of the therapeutic effect. In 1 ml solution for inhalation contains 7.5 mg of ambroxol, therefore, its dosage is carried out in ml using a measuring cup. Dosing regimen depends on age:

  • Children up to 2 years old - the drug is used in an amount of 1 ml 1-2 times a day (total daily dose - 7.5-15 mg). Its use is possible only after prescription.
  • From 2 to 6 years - 1 ml of solution 3 times a day (daily dose of ambroxol - 22.5 mg).
  • From 6 to 12 years - the dose is increased, the drug is used in 2 ml of solution 1-2 times a day (15-30 mg of ambroxol per day).
  • For children over 12 years old and adults, the first 2–3 days from the onset of the disease of the respiratory system is administered at a dose of 4 ml 2 times a day (60 mg ambroxol per day). Then, they switch to the maintenance regimen of the drug in the body - 4 ml 1 time per day (daily dose of 30 mg of ambroxol).

These dosages are general recommendations. In general, the doctor selects the dose of the drug individually, depending on the severity of the pathological process in the bronchi and lungs.

Side effects

Inhalation solution Ambrobene is well tolerated. However, it is possible the development of side effects after its use, which include:

  • On the part of the digestive system - nausea, vomiting develops more often, diarrhea, dryness of the oral and pharyngeal mucosa, abdominal distension, abdominal pain (spastic) can occur less often.
  • On the part of the nervous system - the development of changes in taste sensations (this side effect can develop quite often).
  • On the immunity side, the delayed-type hypersensitivity reaction rarely develops (with each subsequent use of the drug, the response on the part of the immune system develops more pronounced).
  • Allergic reactions - develop very rarely (less than 0.01%), characterized by rash and itching of the skin, the appearance of urticaria, angioedema. In severe cases, anaphylactic shock may develop.

special instructions

Before using the solution for inhalation Ambrobene, you must carefully study the instructions. There are several features of the use of Ambrobene:

  • It is advisable to use the drug is not on an empty stomach, in order to reduce its negative impact on the gastric mucosa and duodenal ulcer.
  • The duration of drug treatment is determined by the attending physician, usually the course of therapy is a period of time before the coughing symptoms stop.
  • Children under the age of 2 years, the drug is prescribed only by a doctor on an individual basis.
  • In the event of any negative reactions of the body after Ambrobene, you should stop using it and consult a doctor.
  • Nursing women use Ambrobene is not recommended, except for the cases of prescription of the drug by a doctor, if the benefit to the woman significantly exceeds the possible risk of negative reactions in the body of the fetus.
  • Ambrobene is used with extreme caution in patients with pathology of the liver and kidneys, which is accompanied by a violation of the functional activity of these organs. With its use, laboratory monitoring of the functional state of these organs is mandatory.
  • With the combined use of Ambrobene with antibiotics ( amoxicillin , cefuroxime), their concentration in the sputum increases, which speeds up the treatment of bacterial bronchitis, pneumonia or tracheitis.
  • The use of the drug does not affect the speed of human reaction, so it can be used when performing work that requires increased attention and quick response.

The drug is non-prescription, it is freely released in the pharmacy chain. In case of any questions or doubts, before using Ambrobene inhalation solution for inhalation, you should consult with your doctor.


Overdose

Symptoms of a significant increase in the dose of the drug above therapeutic include diarrhea (diarrhea) and marked excitement of the central nervous system. In case of overdose, gastric and intestinal lavage and symptomatic therapy is applied.

Terms and conditions of storage

The shelf life of the drug is 5 years from the date of its manufacture. Keep Ambrobene at a temperature not higher than + 25 ° C out of the reach of children. It is also advisable not to leave the drug under the influence of light.

Analogues Ambrobene

For drugs in which the active substance is Ambroxol, include - Ambrosan, Lasolvan, Bronkhoksol, Medox, Flavamed.

Prices in Ambrobene

Ambrobene solution for oral administration and inhalation, 40 ml bottle - from 102 rubles.

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