The Ambrogen solution for inhalation and ingestion: instructions for use, price, reviews, analogues Ambrobene
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Ambrogen solution for inhalation and ingestion Instructions for use

Ambrogen solution for inhalation and ingestion

Solution for inhalation Ambrobene belongs to the group of expectorant drugs. The active substance of this drug is ambroxol, it dilutes sputum and improves its excretion from the lungs and bronchi by coughing of various etiologies.

Dosage form and composition

Ambrobene is produced in the form of a solution for inhalation with the help of special inhalers. This allows for a good penetration of the active substance of the drug into the bronchi and lungs, where it has a therapeutic effect. The main active substance is ambroxol, which belongs to the group of expectorating medicines (mucolytics). Its concentration in the solution is 7.5 mg / ml. Auxiliary substances and their concentration in 1 ml of solution:

  • Potassium sorbate - 1 mg.
  • Hydrochloric acid 0.6 mg.
  • Purified water is 991.9 mg.

In quantitative terms there are 2 types of solution for inhalation Ambrobene - 40 and 100 ml. The bottles are made of dark glass to prevent the destruction of the active substance under the influence of light. The kit includes a measuring cup, which ensures the convenience of dosage during its use.



Pharmacological action of the drug

The therapeutic effect of the solution for inhalation Ambrobene is provided by the main active substance - ambroxol. It belongs to the pharmacological group of expectorant drugs (mucolytics) and has several effects, which include:

  • Secretion-motor action is an increase in the activity of the ciliated epithelium lining the mucous membrane of the respiratory tract (trachea, bronchi and alveoli). In this case, the activity of the movements of the cilia lining the surface of the cells is enhanced, thereby accelerating the excretion of sputum - an improvement in mucociliary clearance.
  • Secretolitic action - ambroxol stimulates the production of enzymes, which destroy intramolecular bonds of mucopolysaccharides of sputum, due to which it becomes less dense. This facilitates its removal from the respiratory tract. Also, ambroxol enhances the activity of cells that produce more liquid sputum (serous cells).

All these effects contribute to sputum expectoration. The cough gradually becomes wet. With sputum, bacteria or other foreign agents that caused inflammation of bronchial mucosa, bronchioles and the development of cough are also derived. The expectorant effect of ambroxol occurs already 10 minutes after inhalation of the solution and lasts about 8-10 hours. After entering the body, ambroxol is metabolized in baking with the formation of metabolic products, which are excreted by the kidneys. Half-life (deducing 50% of the initial concentration of the drug in the body) is 6-12 hours. The active substance solution for inhalation enters the breast milk, which must be taken into account when breastfeeding.

Indications for use

Application of a solution for inhalation Ambrobene is indicated for improving the excretion of sputum from the respiratory tract in diseases accompanied by inflammation in them and congestion of viscous sputum. These include:

  • Acute or chronic infectious bronchitis - inflammation of the bronchial mucosa, caused by bacteria or viruses, which is accompanied by a cough and secretion of viscous sputum.
  • Bronchoectatic disease is a chronic pathology of the bronchi with the formation of extensions in the bronchial tree, a violation of the function of external respiration, the accumulation of thick sputum and secondary infection.
  • Bronchial asthma is an allergic reaction of the respiratory system, accompanied by spasm (constriction) of the bronchi and secretion of a large amount of viscous sputum.
  • Pneumonia is an inflammation of the lungs of infectious etiology.
  • Chronic obstructive bronchitis is a prolonged inflammation of the bronchi caused by the toxic effects of various chemical compounds, in particular long-term smoking.
  • Tracheitis - inflammation of the mucous trachea of ​​any etiology.
  • Cystic fibrosis - a serious hereditary pathology, in which the synthesis of sputum is broken, it is produced very viscous and constantly accumulates in the airways.

The drug is undesirable to use in combination with antitussive drugs, which reduce the severity of the cough reflex, as this can lead to sputum stagnation in the lungs and bronchi.

Contraindications

Use of solution for inhalation Ambrobe is contraindicated in such cases:

  • A marked sensitivity to ambroxol or other auxiliary components of the drug.
  • Peptic ulcer with localization of ulcers in the stomach or duodenum.
  • Pregnancy in the early term (I trimester).

In pregnancy for the second and third trimester Ambrobe can only be used as prescribed by the doctor, when the expected benefit exceeds the potential risk for the growing fetus.


Methods of application and dosage

Use Ambrobe can be inside or in the form of inhalation with the help of an inhaler. With inhalation, the active substance accumulates in the bronchi and bronchioles faster, which accordingly reduces the period of onset of the therapeutic effect. In 1 ml solution for inhalation contains 7.5 mg ambroksola, so its dosage is carried out in ml with a measuring cup. Dosing regimen depends on age:

  • Children up to 2 years - the drug is used in an amount of 1 ml 1-2 times in the knock (total daily dose - 7.5-15 mg). Its use is possible only after the appointment of a doctor.
  • From 2 to 6 years - 1 ml of solution 3 times a day (daily dose of ambroxol - 22.5 mg).
  • From 6 to 12 years - the dose increases, the drug is applied to 2 ml of solution 1-2 times a day (15-30 mg ambroksola per day).
  • Children older than 12 years and adults, the drug, the first 2-3 days from the onset of the disease of the respiratory system, is used in a dose of 4 ml 2 times a day (60 mg ambroksola per day). Then they switch to a maintenance regimen of drug intake into the body - 4 ml 1 time per day (daily dose of 30 mg ambroksola).

These dosages are general recommendations. In general, the dose of the drug the doctor selects individually, depending on the severity of the pathological process in the bronchi and lungs.

Side effects

Solution for inhalation Ambrobe transferred well. Nevertheless, development of side effects after its application is possible, which include:

  • On the part of the digestive system, nausea, vomiting often develops, diarrhea, dryness of the oral cavity and pharynx, abdominal distention, and abdominal pain (spastic) are more rare.
  • From the side of the nervous system - the development of changes in taste sensations (this side effect can develop quite often).
  • On the part of immunity - the reaction of delayed hypersensitivity develops infrequently (with each subsequent application of the drug, the reaction from the immune system develops more pronounced).
  • Allergic reactions - develop very rarely (less than 0.01%), characterized by skin rash and itching, the appearance of urticaria, and edema of Quincke. In severe cases, anaphylactic shock may develop.

special instructions

Before using Ambrobene inhalation solution, you should carefully read the instructions. There are several features of the Ambrobene application:

  • It is desirable to use the drug not on an empty stomach to reduce its negative effect on the mucous membrane of the stomach and duodenum.
  • The duration of treatment with the drug is determined by the attending physician, usually the course of therapy is a period of time before the cessation of cough phenomena.
  • Children under the age of 2 years, the drug is prescribed only by a doctor individually.
  • In case of any negative reactions to the body after the application of Ambrobe, it is necessary to stop using it and consult a doctor.
  • It is not recommended to use Ambrobe for breastfeeding women, except cases when the doctor prescribes the drug, if the benefit for a woman significantly exceeds the possible risk of developing negative reactions in the fetus.
  • With extreme caution Ambrobe is used in persons with liver and kidney pathology, which is accompanied by a violation of the functional activity of these organs. When using it, laboratory monitoring of the functional state of these organs is mandatory.
  • When Ambrobene is used together with antibiotics ( amoxicillin , cefuroxime), their concentration in sputum increases, which speeds up the treatment of bacterial bronchitis, pneumonia or tracheitis.
  • The use of the drug does not affect the reaction rate of a person, so it can be used for work that requires increased attention and quick response.

The drug is over-the-counter, it is freely released in the pharmacy network. In case of any questions or doubts, before using Ambrobene inhalation solution, it is necessary to consult a doctor.

Overdose

Symptoms of a significant increase in the dose of the drug above the therapeutic include diarrhea (diarrhea) and marked excitation from the central nervous system. In case of an overdose, gastric, intestinal and symptomatic washing is used.

Terms and conditions of storage

Shelf life of the drug is 5 years from the date of its manufacture. Store Ambrofen at a temperature not higher than + 25 ° C in a place inaccessible to children. It is also desirable not to leave the drug under the influence of light.

Analogues Ambrobene

The drugs, in which the active substance is ambroxol, are - Ambrosan, Lazolvan, Bronhoksol, Medox, Flavamed.

Prices for Ambrobe

Ambrobene solution for ingestion and inhalation, a bottle of 40 ml - from 102 rubles.

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