Amaril Instructions for use

Content:

Amaril Instructions for use

Amaryl is a modern medicine for the treatment of type 2 diabetes.

Composition

Amaril is available in tablet form in several dosages: 1, 2, 3 and 4 mg. Its properties are due to the active ingredient - glimepiride, a sulfonylurea derivative. Lactose monohydrate, povidone, magnesium stearate, microcrystalline cellulose and E172 or E132 dyes are used as excipients.

Regardless of the dosage, all tablets have a separating risk and engraving. As a distinctive feature - the color of the pill itself: in 1 mg pink, 2 mg - green, 3 mg - pale yellow and 4 mg - blue.

Indications for use

Indications for appointment are:

Monotherapy for type 2 diabetes;
Combined therapy of diabetes mellitus (with insulin and metformin).

Contraindications

The drug is contraindicated in the following cases:

1 type of diabetes;
severe forms of liver and kidney disease due to the lack of clinical trials in these patients;
pregnancy and lactation (switching to insulin therapy is recommended);
diabetic ketoacidosis, coma and precoma;
hypersensitivity to the drug and its components and other sulfonylurea derivatives.

Care should be taken in the first weeks of application of Amaril, in the event of the occurrence of risk factors for hypoglycemia, lifestyle changes (diet, physical activity, etc.) and impaired absorption of drugs and food during intestinal paresis and ileus.

Application features

The course of treatment with amaril is long and has its own characteristics. For example, it is important not to skip the next meal.

The drug is taken whole or divided into equal parts along the risks, if necessary. Washed down with plenty of water.

The initial dose - 1 time / day for 1 mg can be increased gradually, with the interval is 1-2 weeks. Dosage adjustment procedure: 1-2-3-4-6- (8) mg / day.

The distribution of doses and time of admission depends on lifestyle and metabolism. Thus, the daily dose is taken at one time before a full breakfast. Skipping the drug, it is important to do this before lunch or dinner in the same dose.

Amaril dose adjustment is necessary when lifestyle changes, weight loss, risk factors for the development of hypoglycemia. Among the latter are malnutrition and skipping meals, drinking alcohol, glimepiride overdose, impaired carbohydrate metabolism, kidney and liver functions.

Important : There is no exact correlation between dosages of amaril and oral hypoglycemic drugs. The initial dosage is always 1 mg, even if the patient had previously taken the maximum dose of another drug.

With poorly controlled diabetes, combinations of amaril and other hypoglycemic drugs may be prescribed. Metformin and insulin are most commonly used. In the first case, the preservation of doses and the introduction of an additional low dose of two drugs. In the second - the dose of glimepiride is unchanged, and insulin gradually increases.

Side effects

With the use of Amaril, side effects from the organs of sight, blood formation, metabolism and digestive tract are possible.

The development of hypoglycemia with its characteristic symptoms - the feeling of hunger and nausea, drowsiness and fatigue, impaired alertness and attention, visual disturbances, tremor, bradycardia and shallow breathing. There may also be a sticky sweat, angina, and anxiety, and the clinical picture is like a stroke.
A change in glucose concentration causes visual disturbances.
Abdominal pain, diarrhea, vomiting and nausea, stopping with drug withdrawal.
Allergic reactions in mild form (skin rash, itching and urticaria ), and severe (allergic vasculitis , anaphylactic shock and reactions with a sharp drop in blood pressure and shortness of breath).

Overdose

Acute overdose and long-term use of Amaril can lead to severe hypoglycemia, the symptoms of which are described in side effects. To eliminate it, you should immediately take carbohydrates (sugar cube, sweet tea or juice), except for sugar substitutes.

In severe cases, hospitalization, gastric lavage and the use of adsorbents (for example, activated carbon) are indicated.

Drug interaction

Enhances hypoglycemic effect simultaneous application AMARE with insulin, other antidiabetic drugs, certain antibiotics (tetracyclines, sulfonamides, clarithromycin), high dose of pentoxifylline, fluoxetine, fluconazole, anabolic steroids, ACE inhibitors (captopril, enalapril, ramipril, perindopril, lisinopril, etc.). . The combination of amaril with barbiturates, laxatives, diuretics, high doses of nicotinic acid, rifampicin will have the opposite effect.

Strengthening and reducing the hypoglycemic effect of amaril can cause beta-blockers (carvedilol, atenolol, bisoprolol, metoprolol, etc.), reserpine, clonidine, coumarin derivatives and alcohol.