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Allopurinol instructions for use

Allopurinol instructions for use

Allopurinol is a drug that has an arthritic effect on the body and helps to reduce the concentration of uric acid.

Drug release form

Allopurinol is available in the form of coated tablets with dosages of 100 and 300 mg.

Pharmacological properties of the drug

Allopurinol tablets, when ingested, promote the dissolution of urate stones and a decrease in the concentration of urea in the body.

When taking a single dose, the maximum concentration of the main active ingredient, allopurinol, is reached in serum after 5 hours. The active substance of the drug rapidly disintegrates into metabolic products, and part of it is eliminated naturally through the kidneys.

Indications for use of the drug

The main indications for the use of Allopurinol tablets are the following states:

  • Increased serum uric acid concentration - this condition is checked by blood tests, which are given strictly on an empty stomach;
  • Identified stones and sand in the urinary tract and kidneys - the drug is shown only in the case when the stone does not overlap the ureter, and its size does not exceed 2 mm in diameter;
  • Gout ;
  • Violations of metabolic processes in the body, namely, purines and pyrimidines;
  • As part of complex therapy for acute and chronic myeloid leukemia;
  • In the complex treatment of acute leukemia;
  • In the complex treatment of lymphosarcoma;
  • Psoriasis ;
  • Numerous injuries and pathologies of the musculoskeletal system, which can lead to numerous disorders of metabolic processes in the body;
  • Side effects that develop in a patient as a result of prolonged or uncontrolled treatment with glucocorticoids or their analogs of synthetic origin;
  • After a course of cancer chemotherapy, to prevent the formation of urate stones in the urinary organs.

Contraindications

Before you start using this drug, you must carefully read the instructions. Allopurinol therapy is absolutely contraindicated in the following conditions:

  • Individual intolerance to the components of the drug;
  • Age up to 15 years;
  • Hepatic or renal failure in the stage of decompensation;
  • The period of breastfeeding or pregnancy.

Dosage and administration

Allopurinol tablets should be taken orally, without chewing after a meal. For each individual patient, the doctor determines the optimal and effective dose, which directly depends on his diagnosis, body weight, age, and the presence of comorbidities. The average daily rate of the drug for an adult is from 100 to 900 mg. The number of doses per day is determined by the doctor, but, as a rule, tablets should be taken 2-3 times a day at regular intervals.

In pediatric practice, this drug is not used, except for persons under 15 years old who are undergoing treatment for cancer tumors and develop severe metabolic disorders, accompanied by an increased content of uric acid in the body.

Side effects

In most cases, this drug is well tolerated by the patient, provided that they strictly comply with the dosage specified by the doctor. Sometimes a patient may develop side effects during treatment with allopurinol, which manifest themselves with the following symptoms:

  • – боли в животе, понос, рвота, тошнота, обильное слюноотделение, воспаление печени и ее увеличение в размерах, развитие язвочек в ротовой полости; On the part of the digestive system - abdominal pain, diarrhea, vomiting, nausea, abundant salivation, inflammation of the liver and its increase in size, the development of ulcers in the mouth;
  • – замедление количества сердечных ударов минуту, повышение артериального давления, ощущение, что пациент сейчас задохнется; On the part of the cardiovascular system , a slowdown in the number of heart beats per minute, an increase in blood pressure, a feeling that the patient is now suffocating;
  • — нарастающая слабость, сильные головные боли или головокружения, подавленность и депрессия, апатия к происходящему, заторможенность, сонливость, снижение остроты зрения; On the part of the central nervous system - increasing weakness, severe headaches or dizziness, depression and depression, apathy to what is happening, lethargy, drowsiness, reduced visual acuity;
  • – развитие воспалительных процессов почечной ткани, отеки, уремия, значительное повышение количества эритроцитов в моче, в результате чего она приобретает красноватый цвет, трудности с наступлением зачатия, гинекомастия у мужчин – увеличение грудных желез, нарушения эрекции; On the part of the urinary and reproductive system - the development of inflammatory processes of the renal tissue, edema, uremia, a significant increase in the number of red blood cells in the urine, as a result of which it becomes reddish, difficulties with the onset of conception, gynecomastia in men - an increase in the mammary glands, erection disorders;
  • – уменьшение количества тромбоцитов в анализе крови, развитие апластической анемии, уменьшение количества лейкоцитов; On the part of the hematopoietic system - a decrease in the number of platelets in the blood test, the development of aplastic anemia, a decrease in the number of leukocytes;
  • – появление сыпи на коже, зуд кожи, повышение температуры тела, не обусловленное простудными или инфекционными заболеваниями, боли в области суставов, покраснение кожных покровов; Allergic reactions - a rash on the skin, itching of the skin, fever of the body, not caused by colds or infectious diseases, pain in the joints, redness of the skin;
  • ; Development of baldness ;
  • . The appearance of boils in different parts of the body .

special instructions

Allopurinol tablets with extreme caution should be prescribed to patients with disorders in the functioning of the thyroid gland or other organs of the endocrine system. In addition, tablets of this drug with caution should be taken by patients with severe disorders of the kidneys and liver.

During the period of treatment with this drug, the patient should closely monitor the daily volume of fluid consumed, which is at least 2 liters.

During the course of treatment with allopurinol, transport must be managed with caution, since the effect of the active substances on the central nervous system may slightly suppress or slow down the reaction rate.

Allopurinol and alcoholic beverages are absolutely incompatible, therefore it is strictly forbidden to drink alcohol during the period of use of the drug.


Storage conditions, leave and shelf life of the drug

Tablets must be stored in a dark, cool place out of the reach of children. The shelf life of the drug is 3 years from the date of manufacture, which is indicated on the package. Allopurinol is available in pharmacies without a prescription.

Analogs of Allopurinol tablets

Analogs on the active substance: Allopurinol Egis; Allupol; Alopron; Purinol; Sanfipurol

Allopurinol prices

Allopurinol tablets 100 mg, 50 pcs. - from 408 rubles.

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