Actovegin injections instructions for use
The components of the solution of Actovegin are physiological, therefore it is not possible to study their pharmacokinetics after entering the body. Actovegin realizes its effect by enhancing energy metabolism. It accelerates the utilization of oxygen and thus increases the resistance to oxygen starvation in the tissues of the human body.
Form of issue and composition
The active ingredient of the drug is deproteinized hemoderivat from calf blood at a dosage of 40 mg per milliliter of solution. Injectable form of Actovegin is produced in ampoules of different volume and dosage:
- solution of 400 mg, in the package 5 ampoules of 10ml each;
- solution of 200 mg, in the package 5 ampoules of 5 ml each;
- solution of 80 mg, in the package 25 ampoules of 2ml.
Ampoules are in a plastic container. Secondary packaging is made of cardboard. On it there is information about the production series and the term of validity. Inside the carton, in addition to the container with ampoules, there is also a detailed instruction. The color of the solution is yellowish with different shades depending on the release series. The intensity of coloring does not affect the sensitivity to the drug and its effectiveness.
Indications for use
Actovegin can be prescribed in many painful conditions. Its use is justified for such diseases:
- therapy of hemorrhagic stroke and residual phenomena after it;
- encephalopathies of different origins;
- failures observed in the work of venous, peripheral or arterial blood;
- ischemic stroke;
- various craniocerebral injuries;
- angiopathy, especially of diabetic origin;
- radiation, thermal, solar, chemical burns up to 3 degrees;
- polyneuropathy diabetic peripheral;
- trophic damage;
- Wounds of different genesis that are difficult to treat;
- ulcerative skin lesions;
- emerging bedsores;
- damage to the mucous membranes and skin, provoked by radiation damage;
- radiation neuropathies.
Since Actovegin is considered a physiological drug, the only contraindication is hypersensitivity reactions.
Dosing and Administration
For an intravenous route of administration, Actovegin may be administered by drip or jet. Before entering the vein, you must dissolve the drug in a solution of sodium chloride 0.9% physiological or in a glucose solution of 5%. The resolved final dose of Actovegin is up to 2000 mg of dry matter per 250 ml of solution.
For the administration of / a Actovegin should be used in a dosage of 5 to 20 ml per day.
The dose when administered intramuscularly can not exceed 5 ml in 24 hours. In this case, the administration is slow.
After assessing the patient's condition, the required dose is selected. The recommended dosage at the beginning of therapy is 5 to 10 ml of IV or IV. In the following days, intravenously, 5 ml or intramuscularly daily or several times during the 7 day period. Intramuscular injections are slow.
When the patient is in a serious condition, the administration of Actovegin is recommended by intravenous drip in a dose of 20 to 50 ml per day for several days until the condition improves.
In cases of exacerbations of various chronic conditions and in diseases characterized by moderate severity, it is necessary to inject Actovegin in / m or IV in 5-20 ml with a course of 14 to 17 days. Selection of dosage is carried out only by a doctor!
If the planned course of therapy is necessary, the drug can be administered in a dosage of 2 to 5 ml in 24 hours by the way of insertion into the muscle or vein by a course of 4-6 weeks.
Multiplicity of administration should be from 1 to 3 times. This number varies depending on the patient's initial condition.
When treating patients with diabetic polyneuropathy, it is better to start using Actovegin from intravenous administration. Dosage in this case is 2 g per day, the course of treatment is 21 days. In the future, the transition to a tablet form with a daily dose of 2 to 3 tablets over a period of 24 hours is desirable. The course of reception in this way about 4 months.
According to numerous studies, injections of Actovegin are well tolerated by patients. Anaphylactic reactions, allergic manifestations and anaphylactic shock are rare. Sometimes such side effects may appear:
- soreness at the injection site or redness of the skin;
- pain in the head. Sometimes they can be accompanied by a feeling of dizziness, general weakness in the body, the appearance of trembling;
- loss of consciousness;
- dyspeptic manifestations: vomiting, diarrhea, abdominal pain, sensation of nausea;
- tachycardia ;
- sudden blanching of the skin;
- rash on the body ( urticaria ), itching of the skin, flushing of blood, edema angioedurotic;
- joint pain or muscle pain;
- decrease or, conversely, increase in blood pressure indicators;
- soreness in the lower back;
- excited state;
- problems with breathing;
- difficulty in swallowing;
- sore throat;
- sensation of squeezing in the chest;
- increase in temperature indicators;
- increased sweating.
A solution of Actovegin is considered hypertensive, therefore intramuscular injection should not exceed a dosage of 5 ml.
There is a risk of anaphylactic shock. For its minimization, it is recommended to pre-test the perception of Actovegin by the body of each individual patient. For this, a sample of 2 ml of the solution is administered intramuscularly, with further monitoring of general and local reactions.
The injection form of Actovegin is compatible with isotonic solutions of glucose or sodium chloride. In addition to the above combinations, Actovegin should not be mixed with other medicaments in the form of a solution.
When bearing pregnancy and in the lactation period, the solution of Actovegin can be used only for vital indications.
In pediatric practice, injections of Actovegin are not prescribed.
The effect of the drug agent Actovegin on the reaction rate has not been studied. It is necessary to consider the possibility of occurrence of the above-mentioned side effects, especially from the nervous system.
A solution of Actovegin has one analogue - a solution of Solcoseryl for injection.
Terms and conditions of storage
Storage solution should take place in a place protected from the light source, with a temperature regime of no higher than 25 degrees Celsius.
Actovegin injection for injection price
Actovegin solution for injection 2ml, 5 ampoules - 530-570 rub.
Actovegin solution for injection 2ml, 10 ampoules - 750-850 rub.
Actovegin solution for injection 5ml, 5 ampoules - 530-650 rub.
Actovegin solution for injection 5ml, 10 ampoules - 1050-1250 rub.
Actovegin solution for injection 10ml, 5 ampoules - 1040-1200 rub.