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Aksamon: instructions for use

Aksamon: instructions for use

Axamon is a reversible inhibitor of cholinesterase, which increases the conductivity of impulses in the neuromuscular synapse and the central nervous system, resulting from the blockade of potassium channels of the membrane. Its use enhances the effects of acetylcholine, histamine, adrenaline, oxytocin and serotonin on smooth muscles.


One tablet of the drug Aksamon contains: 20 mg ipidacrine hydrochloride monohydrate, which is the active component. Among the excipients, 1 mg of calcium stearate, ludipress - 65 mg, sodium carboxymethyl starch, 14 mg.


Pharmacological effects that Axamon has:

  • Improving memory, stopping the progressive development of dementia;
  • Stimulation and improvement of neuromuscular transmission and conduction of impulses in NA;
  • Increased contraction of smooth muscle organs that are affected by various receptor agonists;
  • Improvement of conductivity in peripheral NS, which is impaired under the influence of local anesthetics, antibiotics, and injuries.

This drug does not affect the human endocrine system.


The drug is characterized by rapid absorption in the / m and subcutaneous administration. The maximum concentration of the drug in the blood is observed 20-30 minutes after it was administered. The tool quickly enters the body's tissues and is 40-50% bound to plasma proteins.

The process of metabolization takes place in the liver. Removal of the drug mainly occurs through the kidneys and extrarenally.

The half-life of Axamon when out of gastric administration is several hours. After such an introduction, the third part of the drug is excreted unchanged in the urine.

Indications for use

This drug is used for such indications:

  • The recovery period after organic lesions of the central nervous system, in which there is a violation of movements, bulbar paresis and paralysis;
  • Polyneuropathy, neuritis, myasthenic syndromes, polyneuritis, myasthenia, polyradiculopathy;
  • Complex treatment and demyelinating pathologies;
  • Encephalopathies of various genesis, senile dementia and Alzheimer's disease.

Special instructions for use

The use of Axamon is not comparable to the use of alcohol and activities that require increased attention and reaction. It is undesirable to use the drug to drivers, people with diseases of the cardiovascular system, ulcers, thyrotoxicosis.

The medication is taken only as prescribed by the attending physician and under his constant supervision.

The drug is available on prescription.


Contraindications to the use of this drug are:

  • Angina pectoris ;
  • Mechanical obstruction of the urinary ducts or intestines;
  • Epilepsy;
  • Hypersensitivity to the components of the drug;
  • Age up to 18 years;
  • Bradycardia;
  • Disorders of the vestibular apparatus;
  • Exacerbation of gastric ulcer or duodenal ulcer;
  • Lack of lactase;
  • Breastfeeding period and pregnancy;
  • Extrapyramidal disorders with hyperkinesis;
  • Intolerance to galactose.

Use the drug with caution should be with such violations of the body: acute respiratory diseases, thyrotoxicosis, impaired intracardiac conductivity, the remission period of gastric or duodenal ulcers.

Dosage and methods of use of the drug

The drug can be used orally, subcutaneously and intramuscularly. In case of violation of the peripheral system, 20 mg is prescribed, which is used 3 times a day. For Alzheimer's pathology, the dosage is prescribed by the attending physician and can vary from 10 to 20 mg, 2 or 3 p / day. Myasthenic syndrome, demyelinating lesions of NS, myasthenia is treated with a dose of 20-40 mg, 4 to 5 times a day. The maximum daily dose is 200 mg. The course of treatment depends on the severity of the pathology and can range from 1 month to a year. Large doses of the drug are recommended to be taken with a small interval (from 2 to 3 hours). Atonia of the intestine is treated with a dosage of 15-20 mg, 2-3 p / d, for 2 weeks.

Side effects

In fact, in all cases, this drug is well tolerated by the body. But there may be cases of side effects, among which may be:

  • Pain in the chest;
  • Ataxia;
  • Miosis;
  • Nausea;
  • Headaches;
  • Bradycardia;
  • Skin rashes;
  • Jaundice;
  • Vomiting;
  • Bronchospasm;
  • Cramps ;
  • Decreased appetite;
  • Increased intestinal motility;
  • Diarrhea;
  • Lowering the temperature;
  • Sweating;
  • Tremor of the limbs.


In cases of overdose of the drug can be such manifestations: arrhythmia, lacrimation, vomiting, anxiety and panic, spontaneous urination and defecation, fear, low blood pressure, constriction of the pupils, coma, general weakness, impaired intracardiac conduction, nystagmus.

In case of overdose, it is recommended to carry out a gastric lavage, use m-holinoblokitoratory (metocinium iodide, atropine, trihexyphenidyl), conduct symptomatic therapy.

Drug interactions

When used in conjunction with drugs that depress the work of the central nervous system, an increase in the sedative effect is observed. Strengthening of side effects occurs when combined with m-cholinomimetic drugs and cholinesterase inhibitors.

This remedy in use with various cholinergic drugs for myasthenia increases the risk of a cholinergic crisis.

The use of β-blockers enhances the risk of bradycardia.

The use of such a drug and the use of alcohol leads to increased side effects.

Release form and shelf life

The drug is available in the form of tablets and solution for administration. In the package of 5 plates on 10 tablets (20 mg). For subcutaneous and intramuscular administration, release 5 ampoules per pack of 1 ml.

The shelf life of the drug - 3 years from the date of manufacture.

Analogs of Axamon

Structural analogues of the drug include: Amiridin, Ipidacrine and Neuromidin.

Price for Axamon

Aksamon tablets 20 mg, 50 pcs. - from 628 rubles.

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