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Aksamon injections: instructions for use

Aksamon injections

Aksamon injections refers to cholinesterase inhibitors and is used for subcutaneous and intramuscular administration in the treatment of diseases of the nervous system.

Composition

Aksamon solution is a colorless liquid with the active ingredient - ipidacrine hydrochloride monohydrate. As excipients, the dosage form contains water for injection and a solution of hydrochloric acid (0.1 M). In the pharmacy assortment is presented in two concentrations: 5 mg / ml and 15 mg / ml.

Pharmacological properties and indications for use

The chemical composition of the drug and certain excipients give it the appropriate pharmacological properties:

  • Stimulation of nerve impulses;
  • Improving conductivity, impaired inflammation and caused by prolonged use of potassium chloride, some antibacterial drugs and local anesthetics, injuries and other factors;
  • Inhibition of dementia, characterized by the degradation of thinking, behavior and memory, and memory improvement.

Indications for the use of the drug are diseases of the central and peripheral nervous system (paresis, paralysis, polyneuropathy, myasthenia, etc.), intestinal atony, and rehabilitation of a patient with organic lesions of the central nervous system and motor disorders.

Contraindications

Aksamon in injections can not be assigned to children under 18 years of age, since there is no systematic data on clinical studies in this group. Other contraindications are:

  1. Various forms of epilepsy;
  2. Acute stage of gastric ulcer and duodenal ulcer;
  3. Disorders of the vestibular apparatus;
  4. Severe angina and bradycardia;
  5. Intestinal obstruction;
  6. Hypersensitivity to ipidacrine.

Caution should be observed when thyrotoxicosis, acute diseases of the urinary and respiratory systems.

Pregnant Axamon injections is also contraindicated, as it can cause premature labor, increasing the tone of the uterus. Data on the use of the drug during lactation is not available.

Application features

The route of administration (subcutaneously or intramuscularly) and the dosage of the prescribed drug depends on the disease and the characteristics of its course.

  1. Treatment of diseases of the central nervous system
  • For paresis and bulbar paralysis, the drug is administered twice a day intramuscularly or subcutaneously for 10–15 days, with the dosage varying from 5 to 15 mg. After a course of injections, it is possible to use the tablet form of the drug.
  • In the rehabilitation of patients with impaired motor activity and organic lesions of the central nervous system, the following scheme is used: 1-2 times a day, Axamon is administered intramuscularly at a dosage of 10-15 mg for 15 days, and then the patient takes it in tablets.
  1. Treatment of diseases of the peripheral NS
  • With myasthenia gravis and syndrome, Axamon is injected 1-3 times a day at a dosage of 15-30 mg, and then administered in tablet form. The course of treatment is up to 2 months.
  • With polyradiculopathy and neuropathy, triggered by various factors, the drug is administered intramuscularly or subcutaneously for 10 days at a dosage of 5-15 mg. On day 1-2 of the injection. In severe forms of the disease, the course is up to 30 days with the transition to Axamon tablets.
  1. With intestinal atony, the initial dose is 10-15 mg and is administered twice a day for 1-2 weeks.

Side effects

The solution of axamon is well tolerated and does not adversely affect the fetus, liver, and the immune and endocrine systems.

In some cases, the following undesirable effects may develop:

  • Violations of the nervous system and psyche - headache, tremor, convulsions , dizziness and drowsiness;
  • Constriction of the pupil;
  • Bradycardia (slow heartbeat) and chest pain;
  • Nausea and excessive drooling, vomiting, abdominal pain and diarrhea possible;
  • Yellowing, rash, and itching;
  • General weakness, increased sweating.

If an itchy rash occurs, the doctor cancels the drug. With other side effects or short-term use of the drug is interrupted, or reduced dosage.

If you experience side effects that are not listed in the instructions, you should immediately consult a doctor.

Drug interactions

When using the combination of Aksamon and drugs that depress the central nervous system (tranquilizers, antipsychotics, antidepressants, hypnotics, sedatives and anti-manic drugs), the sedative effect is enhanced.

Strengthening of action of Aksamon and development of side effects occurs at use of m-cholinomimetic (Pilokarpin, Atseklidin), other inhibitors of cholinesterase and alcohol.

The combination with cholinergic agents in the treatment of myasthenia increases the risk of a cholinergic crisis. And the early use of β-blockers can lead to bradycardia.

When administered with local anesthetics, potassium chloride and aminoglycosides, a weakening of the inhibitory effect on the transmission and conduction of the impulse along the nerve fibers is observed.

Acceptable simultaneous appointment with nootropics.

Overdose

In case of overdose, side effects are triggered and the following symptoms are observed: bronchospasm, lacrimation, yellowness of the skin, decreased blood pressure and bradycardia, convulsions, impaired speech, anxiety and fear, drowsiness and weakness, constriction of the pupils and uncontrolled urination and defecation.

Treatment involves the use of symptomatic agents and m-cholinoblockers (Cyclodol, Atropine).


Driving while using the drug

When treating axamon, the patient should refrain from the following activities: requiring increased concentration of attention and quick psychomotor reactions, driving and other mechanisms.

Storage conditions

Storage should be protected from light and not accessible to children. The optimum temperature is up to 25 ° C.

Analogs

Structural analogues of Axamon by the active substance: Amiridin, Neyromidin.

Price for Aksamon in ampoules

Aksamon solution for intramuscular and subcutaneous administration of 15 mg / ml, 10 pcs. - from 1000 rubles.

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