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Agapurin instructions for use

Agapurin instructions for use Agapurin is a drug that helps to improve vascular microcirculation, and also strengthens and improves the structure of the vascular wall.

Active ingredient: Pentoxifylline.

Latin name: Agapurin.

Release form

Agapurin is produced in tablets containing 100 mg of pentoxifylline.

pharmachologic effect

Agapurin belongs to the group of purines and has a moderate spasmolytic (i.e., relaxes smooth muscle) effect. Due to this, it improves blood flow even in the vessels of the smallest caliber and helps to improve the rheological characteristics of the blood. The vasodilation caused by Pentoxifylline leads to a decrease in the total peripheral vascular resistance, an increase in the stroke and minute volume of the heart. At the same time, there is no increase in heart rate.

The mechanism for preventing thrombosis is associated with irreversible inhibition of phosphodiesterase, an increase in the concentration of cAMP in platelets and the accumulation of ATP in erythrocytes.

Equally important is the mechanism of influence of Agapurin on the coronary arteries. Pentoxifylline exhibits a moderate antianginal effect due to the expansion of not only the heart vessels, but also the lungs.

The drug has the ability to increase the tone of the diaphragm and intercostal muscles (respiratory muscles).

In case of occlusive diseases of the lower extremities (obliterating endarteritis or atherosclerosis), due to the antispasmodic and antiaggregant action, the drug effectively eliminates nighttime cramps , increases the walking distance, relieves pain in the calf muscles alone.

Pharmacokinetics

After oral ingestion, Agapurin is completely absorbed through the wall of the gastrointestinal tract. After that, it undergoes entero-hepatic circulation with the formation of two active metabolites. The maximum concentration of pentoxifylline in the blood plasma is reached within 1 hour.

The drug is mainly excreted through the system of organs of excretion (kidney). At the same time 90% of the total dose completely leaves the body within 4 hours. Also, the drug is secreted into breast milk during lactation.

In severe degrees of renal failure, the release of the drug is delayed. With liver failure, there is a prolongation of the half-life, as well as an increase in bioavailability.

Indications for use

  • impaired blood supply to tissues in atrosclerosis, diabetes mellitus, and inflammatory processes of various etiologies;
  • impaired blood circulation in the vessels of the brain caused by ischemic vascular lesions;
  • atherosclerotic and dyscirculatory encephalopathy;
  • various genesis of angiopathy ( Raynaud's syndrome );
  • trophic changes in the skin and underlying tissues that have developed as a result of impaired venous or arterial blood flow (post-thrombophlebitic syndrome, gangrene, frostbite, trophic ulcers);
  • endarteritis obliterans;
  • with retinal blood supply disorders;
  • pathology of the middle ear (hearing loss resulting from vascular disorders).

Dosage and administration

Agapurin tablets are taken after a meal, at the same time of day, drinking plenty of water. Chew drug can not.

The starting dose of pentoxifylline is 200 mg 3 times a day for 7 days. In case of a sharp decrease in blood pressure, as well as pathological symptoms of the digestive system or the nervous system, the dose is reduced to 100 mg (equivalent to 1 tablet) 3 times a day.

For maintenance therapy use a dose of 100 mg in the morning, afternoon and evening. In this case, the drug is taken regularly for several months.

The maximum permissible daily dose is 1200 mg.

With a creatinine level of more than 400 mmol / l (chronic or acute renal failure), the dose taken is reduced by 30% or 50%.

Contraindications

  • Acute period of myocardial ischemia (heart attack, unstable angina ).
  • Porphyria.
  • Hemorrhagic stroke in the acute period.
  • Hemorrhage into the retina.
  • Severe atherosclerotic obliteration of coronary or cerebral vessels.
  • Heart rhythm disturbances that are accompanied by hemodynamic disorders.
  • Pregnancy.
  • Age under 18 years.
  • Breast-feeding.
  • Hypersensitivity to the components of the drug.

special instructions

In order to avoid orthostatic collapse, careful control of the level of blood pressure during administration of the drug is necessary.

Patients receiving regular glucose-lowering therapy should regularly monitor their blood glucose, because Pentoxifylline may cause hypoglycemic conditions.

After recent surgical interventions, special care should be taken when prescribing Agapurin. In the event that the use of the drug is absolutely shown to the patient, it is necessary to regularly monitor the parameters of the blood coagulation system.

When treating patients older than 60 years, the dose should be selected strictly individually. At the same time, it is recommended to begin pharmacotherapy with the lowest doses of the drug.

Under the influence of smoking, the pharmacological efficacy of the drug may decrease.


Symptoms of overdose

With multiple exceeding the daily dose of the drug, symptoms may occur such as

  • Loss of consciousness.
  • Redness of the skin.
  • Bleeding from the vessels of the mucous membrane of the digestive tract (vomiting, similar to the "coffee grounds").
  • Chills accompanied by fever.
  • Areflexia.
  • Attack of tonic-clonic convulsions.
  • Drowsiness.
  • Tachycardia .
  • Dizziness.

The drug has no specific antidote, therefore, when intoxication with Agapurin, symptomatic pharmacotherapy is carried out, aimed at maintaining the vital functions of the body.

Drug interactions

Pentoxifylline is able to potentiate the action of drugs that affect the blood clotting process. Among them: indirect and direct anticoagulants, as well as thrombolytics. Summation of side effects can be observed with the combined use of Agapurin with cephalosporin antibacterial agents (1-2 generation). It is also undesirable to use pentoxifylline in conjunction with valproates (valproic acid derivatives).

Due to its pharmacodynamic effects, Agapurin increases the effectiveness of such drugs as: antihypertensive drugs, oral hypoglycemic drugs and insulin.

Histamine receptor blocker Zimetidine is able to increase the concentration of pentoxifylline in serum. This can lead to a number of side effects or overdose symptoms.

You should also not combine Agapurin with xanthines, since such pharmacotherapy can lead to the appearance of symptoms of nervous excitement in the patient.

Use in pregnant and lactating women

The drug is prohibited to use.

Side effects

  • Nervous system: seizures, insomnia, dizziness, anxiety, headache.
  • Soft tissues (subcutaneous fatty tissue and skin): redness (hyperemia) of the face, sensation of hot flushes to the upper part of the body, swelling, increased fragility of the nails.
  • Digestive tract: exacerbation of cholecystitis symptoms, cholestatic hepatitis, dry mouth, intestinal atony, decreased appetite.
  • Sense organs: the appearance of bright spots or circles in front of the eyes, reduced visual acuity.
  • Hematopoietic organs and hemostasis system: decrease in the level of platelets, leukocytes, fibrinogen, bleeding from the vessels of the mucous membranes of the digestive organs.
  • Allergic reactions of immediate or delayed types.
  • Laboratory abnormalities in biochemical analyzes: an increase in ALT, LDG, AST, alkaline phosphatase.

Analogs of Agapurina

Trental, Pentoxifillin, Rivio Forte, Pentamon, Pentoxifylline, Arbiflex-100, Pentiline, Agapurin 600 retards, Arbiflex-400 Vazonit, Agapurin SR

Prices for Agapurin

Agapurin 100 mg coated tablets, 60 pcs. - 200-250р.

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