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Acyclovir cream instructions for use

Acyclovir cream instructions for use

Cream Acyclovir is an antiviral agent for external use. It has a therapeutic effect in various herpetic infections by blocking viral replication.

Release form and composition

Acyclovir cream for external use is available in tubes of 5 g. The active ingredient of the drug is acyclovir, its concentration is 5% (1 g of ointment contains 5 mg of acyclovir). In addition to the active ingredient cream contains auxiliary components, which include:

  • Medical vaseline oil.
  • Emulsifying type cetostearyl alcohol A.
  • Poloxamer 407.
  • Propylene glycol.
  • Dimethicone
  • Purified water.

In one cardboard pack of the drug contains 1 tube with 5 g of cream and instructions for its use. The concentration of the active substance is sufficient to block the replication of viruses.

pharmachologic effect

The active ingredient of the drug acyclovir is a thymidine nucleoside analogue. Its mechanism of action is that after penetrating an infected cell, the viral enzyme thymidine kinase catalyzes the conversion of acyclovir to acyclovir triphosphate, which is incorporated into the genetic material of the virus (DNA) and interferes with the reading of information (transcription), which leads to blocking of the transcription process (formation and assembly of new viral particles). In healthy, virus-free cells, the enzyme thymidine kinase is absent; therefore, acyclovir does not transform into triphosphate form and does not adversely affect the genetic material of the cell. The virus shows the most activity in relation to the herpes viruses (Herpes simplex) and shingles (Varicella zoster). Less effect, the active ingredient of the drug has on cytomegalovirus and Epstein-Barr virus.

When applied topically, the active ingredient of the cream Acyclovir is well absorbed by the cells of the skin and mucous membranes in the area of ​​its application. Acyclovir is practically not absorbed into the systemic circulation.

Indications for use

Cream Acyclovir is indicated for the treatment of skin manifestations of various herpetic infections, which include:

  • Herpes with rashes on the skin in the lips, genitals and other areas of the body.
  • Shingles with the development of a characteristic rash on skin areas corresponding to the innervation of a nerve affected by a viral infection. After applying the cream Acyclovir, the severity of the rash and the intensity of the pain decrease.
  • Chickenpox is an infectious viral process with a rash all over the body in the form of small bubbles filled with fluid.

It is not recommended to apply Acyclovir cream on the mucous membranes of the body.


The use of Acyclovir cream is contraindicated in case of development of individual intolerance to the main active ingredient of the drug or its auxiliary components. It is also not recommended to apply the cream in the presence of allergic reactions, which are mainly manifested by changes in the skin in the form of a rash, itching or rash on the background of swelling of the skin, which resembles a nettle burn (nettle rash ).

Dosage and method of use

Cream Acyclovir is a drug for external use. It is applied to the affected area of ​​the skin, where there are elements of a rash, indicating the presence of a herpes infection. It is also possible to apply the drug in the field of herpes lips and genitals. The multiplicity of applying the cream - 5 times a day, with an interval between application at 4 hours. The duration of treatment is an average of 5 days. If during this time there is no improvement in the skin condition, a decrease in the intensity and severity of the rash, it is possible to extend the course of treatment up to 10 days.

Side effects

Acyclovir cream is generally well tolerated, this is due to the lack of flow of the active substance into the systemic circulation. Perhaps the development of skin allergic reactions after applying a cream on it, which manifests itself in the form of erythema (reddening of the skin), rash, itching or urticaria. In rare cases, the development of angioedema angioedema (pronounced swelling of the skin and subcutaneous tissue, with predominant localization in the area of ​​the face and genitals). In the case of side effects of the drug should be discontinued.

special instructions

Before you start using Acyclovir cream, you should read the instructions for use, which is enclosed in a cardboard box. It is important to pay attention to such special instructions:

  • You can not use Acyclovir cream for the treatment of herpes infection of the eye (keratitis), for this there is a special dosage form of the drug - eye ointment.
  • In the absence of the effect of treatment, consultation with a dermatologist or infectious disease physician is necessary to decide on the use of antiviral drugs for systemic action (pills).
  • It is allowed to use Acyclovir cream for pregnant women and during lactation, as the active ingredient of the drug is not absorbed into the systemic circulation.

In the pharmacy network, Aciclovir cream is sold without a prescription. In case of any questions or doubts, it is advisable to consult a doctor. During the treatment of herpes lips, one should follow the recommendations regarding the prevention of infection of this infection to healthy people (individual dishes and personal hygiene items).


Due to the fact that the active ingredient of the drug is not absorbed into the systemic circulation, overdose cases are unknown. Sometimes with significant application to the skin, side effects such as erythema and allergic reactions may develop.


Similar drugs that contain the same active ingredient are - Acyclostad, Vivorax, Gerpevir, Gerperax, Zovirax.

Terms and conditions of storage

The shelf life of the drug since its manufacture is 2 years. After unpacking and using the ointment, its shelf life is 30 days. It is necessary to store cream Acyclovir in a dark place inaccessible to children with an air temperature of + 15-25 ° C.

Cream Acyclovir price

Acyclovir cream for local and external use of 5%; aluminum tube 5 g - from 27 rubles.

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