Acetylsalicylic acid instructions for use
- Acetylsalicylic acid instructions for use
Acetylsalicylic acid or aspirin belongs to the group of nonsteroidal anti-inflammatory drugs and has strong antipyretic, analgesic and antiplatelet properties.
Drug release form
Acetylsalicylic acid is produced in the form of round-shaped tablets with a horizontal strip in the middle of white. The drug is packaged in blisters or paper packs of 10 pieces.
Pharmacological properties of the drug
Acetylsalicylic acid when ingested into the body contributes to the violation of the synthesis of prostaglandins, substances that play a major role in the development of febrile conditions, inflammatory processes and pain syndrome.
Suppression of prostaglandin production leads to the expansion of blood vessels, which contributes to increased sweating, due to which the antipyretic effect of the drug is explained.
Use in the treatment of drugs based on acetylsalicylic acid leads to a decrease in the sensitivity of the nerve endings, which explains the pronounced analgesic effect of this tool. Acetylsalicylic acid is eliminated from the body through the kidneys.
What helps acetylsalicylic acid
Acetylsalicylic acid tablets are prescribed for adults in order to treat and prevent the following conditions:
- Acute inflammatory processes - inflammation of the heart bag, rheumatoid arthritis , small chorea, pneumonia and pleurisy as part of complex therapy, inflammatory lesions of the periarticular bag;
- Pain syndrome of various origins - severe headaches, toothache, muscle pains with flu and viral infections, menstrual pain, migraines, joint pain;
- Diseases of the spinal column, accompanied by severe pain - osteochondrosis, lumbago;
- Increase in body temperature, fever caused by infectious and inflammatory processes in the body;
- Prevention of myocardial infarction or ischemic stroke for circulatory disorders, thrombogenesis, and thick blood;
- Angina of unstable nature;
- Genetic predisposition to thromboembolism, thrombophlebitis;
- Heart defects, mitral valve prolapse (disruption of its functioning);
- Pulmonary infarction, pulmonary thromboembolism.
Acetylsalicylic acid tablets have a number of contraindications to use. These include:
- Hemorrhagic diathesis and vasculitis;
- Gastritis of erosive or corrosive origin;
- Peptic ulcer and duodenal ulcer;
- Poor blood clotting, bleeding tendency;
- Vitamin K deficiency;
- Dissecting aortic aneurysm;
- Severe disorders in the kidneys and liver;
- Individual intolerance to salicylates or allergic reactions to acetylsalicylic acid in history;
- Arterial hypertension, the risk of hemorrhagic stroke.
Acetylsalicylic acid, how to take?
Acetylsalicylic acid tablets are intended for oral administration. The drug is recommended to be taken at the beginning of a meal or immediately after a meal in order to prevent the development of erosions on the gastric mucosa. The tablets can be washed down with milk, thus, the irritating effect of acetylsalicylic acid on the mucous membranes of the digestive tract will not be so aggressive or use ordinary alkaline water without gas in sufficient quantities.
Adults appoint 1 tablet of 500 mg of the drug 2-4 times a day, depending on the evidence and general health. The maximum daily dose is 3 g and you can not exceed it! The duration of therapy with this drug is determined by the doctor depending on the indications, the severity of the inflammatory process and the individual characteristics of the organism, but this period should not exceed 10-12 days.
For prophylactic purposes, to reduce the risk of myocardial infarction and thrombogenesis, ½ tablet of aspirin is prescribed to adults once a day. The duration of therapy is about 1-2 months. During this period, it is necessary to constantly monitor the clinical picture of the blood, monitor the rate of blood clotting and the number of platelets.
Before using acetylsalicylic acid tablets, the patient should consult a doctor. If you exceed the dose or uncontrolled and long-term use of this drug may develop the following side effects:
- Pains in the field of epigastria, nausea, vomiting;
- Dizziness and weakness;
- Loss of appetite;
- Impaired visual acuity;
- Bleeding - intestinal, nasal, gingival, stomach;
- Changes in the clinical picture of blood - reducing the amount of hemoglobin and platelets;
- Disorders in the liver and kidneys;
- Development of acute renal failure;
- Bronchospasm, in severe cases, the development of angioedema and anaphylactic shock.
Use of the drug during pregnancy and lactation
The drug acetylsalicylic acid is prohibited to take in 1 and 3 trimesters of pregnancy.
According to the research conducted, the use of aspirin tablets in pregnant women in the first 12 weeks greatly increases the risk of developing anomalies in the embryo, namely splitting of the upper palate and congenital heart defects.
The use of the drug in the 2nd trimester is possible with special care and only in the case when the expected benefit to the mother will be higher than the possible harm to the fetus. Tablets are used in strictly specified dosage (minimum effective) and under strict medical supervision. During the period of treatment, the expectant mother should undergo a blood test regularly to assess hematocrit and platelet count.
The use of acetylsalicylic acid in the 3rd trimester is prohibited due to the huge risk of early closure of the aortic duct in the fetus. In addition, the drug can lead to bleeding in the ventricles of the brain in the fetus and cause the risk of massive bleeding in the expectant mother.
The use of acetylsalicylic acid tablets during breastfeeding is prohibited due to the high risk of developing liver and kidney failure in a child. In addition, getting into the body of the baby with the mother's milk, acetylsalicylic acid can lead to severe internal bleeding in a child. If it is necessary to use this drug during the period of breastfeeding, the baby should be transferred to artificial feeding with an adapted milk formula.
Interaction with other drugs
The simultaneous use of aspirin tablets with other drugs from the group of non-steroidal anti-inflammatory substances (ibuprofen, nuroferon, indomethacin and others) increases the risk of side effects listed above and symptoms of overdose. In some cases, patients developed hepatic and renal failure and coma.
With the simultaneous use of acetylsalicylic acid and drugs from the group of antacids, a decrease in the therapeutic effect of aspirin and slowing its absorption into the bloodstream is observed.
Acetylsalicylic acid tablets should not be taken simultaneously with anticoagulants due to the sharp increase in the likelihood of massive internal bleeding and strong blood thinning.
With the simultaneous use of acetylsalicylic acid with diuretics, their therapeutic efficacy decreases.
The simultaneous use of this drug with ethanol can lead to poisoning and intoxication of the body.
Conditions of storage and release of the drug
Acetylsalicylic acid tablets are available over the counter in pharmacies. The drug should be stored for 4 years from the date of manufacture indicated on the package. After this period, the tablets can not be taken orally.
Packing should be kept away from direct sunlight out of the reach of children.
Acetylsalicylic acid analogues
Structural analogues of the active substance: Aspicore, Aspirin, Aspirin Cardio, Acecardol, Acetylsalicylic acid, CardiASK, Cardiomagnyl, Kolpharit, Mikristin, Plydol 100, Plydol 300, Polokard, Taspir, Trombo ACC, Trombogard 100, Thrombo, Trombogard 100, Thrombo AC, Thrombogard 100;
Acetylsalicylic acid price
Acetylsalicylic acid tablets 500mg - from 7 rubles.